Amazon Joint - Muscle Support Amazon
JOINT-MUSCLE SUPPORT
*


120 capsules (650 mg each)

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

A powerful formula of 8 rainforest botanicals which have been traditionally used in South America for arthritis, and muscle and joint pain, strains, and injuries.* For more information on the individual ingredients in Amazon Joint-Muscle Support, follow the links provided below to the plant database files in the Tropical Plant Database.

Ingredients: A herbal blend of cat's claw, chuchuhuasi, amor seco, tayuya, picão preto, iporuru, sarsaparilla, and guaco. To prepare this natural remedy yourself: Use 2 parts cat's claw and one part of each of the remaining plants listed. To make a small amount... "1 part" could be one tablespoon (you'd have 9 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce or one cup or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.

Suggested Use: Take 1 to 1 1/2 grams by weight (or 1 1/2 to 1 teaspoon by volume) every 4-6 hours as needed.

Contraindications:
  • Not to be used during pregnancy or while breast-feeding.
  • Several plants in this formula contain coumarin which has an anticoagulant effect. Individuals with blood disorders such as hemophilia, or those on blood thinning medications should be monitored for this effect.
  • This product should not be used with medications intended to suppress the immune system.
Drug Interactions: May potentiate anticoagulants such as Warfarin®. May reduce the effect of immune suppressive medications. May enhance the effect of antihypertensive medications.

Other Practitioner Observations:
  • Picão preto contains a small amount of naturally occurring caffeine. Those individuals sensitive or allergic to caffeine should avoid this formula.
  • Cat's claw has been documented to have an anti-fertility effect. Those seeking to become pregnant or those undergoing treatment for infertility should consult their doctor prior to use.




Third-Party Published Research*

This rainforest formula has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.

Cat's Claw (Uncaria tomentosa)
Akhtar, N., et al. "Current nutraceuticals in the management of osteoarthritis: a review." Ther Adv Musculoskelet Dis. 2012 Jun;4(3):181-207.
Rojas-Duran, R., et al. "Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark." J Ethnopharmacol. 2012 Oct 11;143(3):801-4.
Allen-Hall, L., et al. "Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB." J. Ethnopharmacol. 2010 Feb 17;127(3):685-93.
Zeng, K., et al. "Synthesis and biological evaluation of quinic acid derivatives as anti-inflammatory agents." Bioorg. Med. Chem. Lett. 2009 Sep 15; 19(18): 5458-60.
Erowele, G., et al. "Pharmacology and therapeutic uses of cat's claw." Am. J. Health Syst. Pharm. 2009 Jun 1; 66(11): 992-5.
Amaral, S., et al. "Plant extracts with anti-inflammatory properties--a new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationships." Bioorg. Med. Chem. 2009 Mar; 17(5): 1876-83.
Yuan, D., et al. "Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism." Int. Immunopharmacol. 2009 Dec; 9(13-14):1549-54.
Pero, R. "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals." United States Patent No. 7,595,064. September 29, 2009
Hardin, S. R. "Cat's claw: An Amazonian vine decreases inflammation in osteoarthritis." Complement. Ther. Clin. Pract. 2007 Feb; 13(1): 25-8.
Allen-Hall, L., et al. "Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha." J. Ethnopharmacol. 2007 Jan; 109(2): 312-7.
Badilla, B., et al. "Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts." Rev. Biol. Trop. 2006 Jun; 54(2):245-52.
Miller, M. J., et al. "The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta." BMC Complement. Altern. Med. 2006 Apr; 6: 13.
Miller, M. J., et al. "Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]." J. Inflamm. 2005 Oct; 2:11.
Valerio, L. G., et al. "Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii): a critical synopsis." Toxicol. Rev. 2005; 24(1): 11-35.
Setty, A. R., et al. "Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects." Semin. Arthritis Rheum. 2005; 34(6): 773-84.
Sheng, Y., et al. “An active ingredient of Cat's Claw water extracts: identification and efficacy of quinic acid.” J. Ethnopharmacol. 2005 Jan 15; 96(3):
Aguilar, J. L., et al. “Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae).” J. Ethnopharmacol. 2002; 81(2): 271–76.
Sandoval, M., et al., “Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content." Phytomedicine. 2002; 9(4): 325–37.
Mur, E., et al. “Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis.” J. Rheumatol. 2002 Apr; 29(4): 678–81.
Sandoval-Chacon, M., et al. “Anti-inflammatory actions of cat’s claw: the role of NF-kappaB.” Aliment. Pharmacol. Ther. 1998; 12(12): 1279–89.
Recio, M. C., et al. “Structural requirements for the anti-inflammatory activity of natural triterpenoids.” Planta Med. 1995; 61(2): 182–85.
Aquino, R., et al. “Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa." J. Nat. Prod. 1991; 54: 453–59.
Cerri, R., et al. “New quinovic acid glycosides from Uncaria tomentosa." J. Nat. Prod. 1988; 51: 257–61.

Chuchuhuasi (Maytenus krukovii, laevis)
Sosa, S., et al. "Anti-inflammatory activity of Maytenus senegalensis root extracts and of maytenoic acid." Phytomedicine. 2007; 14(2-3): 109-14.
Honda, T., et al. “Partial synthesis of krukovines A and B, triterpene ketones isolated from the Brazilian medicinal plant Maytenus krukovii.” J. Nat. Prod. 1997; 60(11): 1174-77.
Morita, H., et al. “Triterpenes from Brazilian medicinal plant “chuchuhuasi” (Maytenus krukovii).” J. Nat. Prod. 1996; 59(11): 1072-75.
Sekar K. V., et al. “Mayteine and 6-benzoyl-6-deacetyl-mayteine from Maytenus krukovii.” Planta Med. 1995; 61: 390.
Bradshaw, D., et al. “Therapeutic potential of protein kinase C inhibitors.” Agents and Actions 1993; 38: 135-47.
Itokawa, H., et al. “Isolation, structural elucidation and conformational analysis of sesquiterpene pyridine alkaloids from Maytenus ebenifolia Reiss. X-ray molecular structure of ebenifoline W-1.” J. Chem. Soc. Perkin. Trans. I 1993; 11: 1247-54.
Itokawa, H., et al. “Oligo-nicotinated sesquiterpene polyesters from Maytenus ilicifolia.” J. Nat. Prod. 1993; 56: 1479-85.
Gonzalez, J. G., et al. “Chuchuhuasha—a drug used in folk medicine in the Amazonian and Andean areas. A chemical study of Maytenus laevis.” J. Ethnopharm. 1982; 5: 73–7
Moya, S., et al. “Phytochemical and pharmacological studies on the antiarthritics of plant origin.” Rev. Colomb. Cienc. Quim. Farm. 1977; 3(2): 5.

Amor Seco (Desmodium adscendens)
Irié-N'guessan, G., et al. "Tracheal relaxation of five Ivorian anti-asthmatic plants: role of epithelium and K? channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark." J Ethnopharmacol. 2011 Nov 18;138(2):432-8.
Rastogi, S., et al. "An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC." J Ethnopharmacol. 2011 Jun 22;136(2):283-96.
N’Gouemo, P., et al. “Effects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents.” J. Ethnopharmacol. 1996; 52(2): 77–83.
Addy, M. E., et al. “An extract of Desmodium adscendens activates cyclooxygenase and increases prostaglandin synthesis by ram seminal vesicle microsomes.” Phytother. Res. 1995; 9(4): 287–93.
McManus, O. B., et al. "An activator of calcium-dependent potassium channels isolated from a medicinal herb." Biochemistry 1993; 32(24): 6128-33.
Addy, M. E., et al. "Several chromatographically distinct fractions of Desmodium adscendens inhibit smooth muscle contractions." Int. J. Crude Drug Res. 1989; 27(2): 81-91.
Addy, M. E., et al. "Some secondary plant metabolites in Desmodium adscendens and their effects on arachidonic acid metabolism." Prostaglandins Leukotrienes Essent. Fatty Acids 1992; 47(1): 85-91.
Addy, M. E., et al. "Effect of Desmodium adscendens fractions on antigen- and arachidonic acid-induced contractions of guinea pig airways." Can. J. Physiol. Pharmacol. 1987; 66(6): 820-25.

Tayuya (Cayaponia tayuya)
Escandell, J. M., et al. "Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus." J Pharmacol Exp Ther. 2010 Feb;332(2):352-63.
Aquila, S., et al. "Anti-inflammatory activity of flavonoids from Cayaponia tayuya roots." J Ethnopharmacol. 2009 Jan 21;121(2):333-7.
Escandell, J. M., et al. "Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of TNF-{alpha} in T lymphocytes and macrophages." J. Pharmacol. Exp. Ther. 2006 Feb; 532(1-2): 145-54.
Escandell, J. M., et al. “Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis.” Eur. J. Pharmacol. 2006 Feb; 532(1-2): 145-54.
Recio, M. C., et al. “Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.” Planta Med. 2004; 70(5): 414-20.
Himeno, E., et al. “Structures of cayaponosides A, B, C and D, glucosides of new nor-cucurbitacins in the roots of Cayaponia tayuya.” Chem. Pharm. Bull. (Tokyo) 1992; 40(10): 2885–87.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake venom—I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86 (Suppl. 2): 203–5.
Rios, J. L., et al. “A study of the anti-inflammatory activity of Cayaponia tayuya root.” Fitoterapia 1990; 61(3): 275–78.
Faria, M. R. and E. P. Schenkel. “Caracterizacao de cucurbitacinas em especies vegetais cohecidas popularmente como taiuiá.” Ciencia e Cultura (São Paulo) 1987; 39: 970–73.
Bauer, R., et al. “Cucurbitacins and flavone C-glycosides from Cayaponia tayuya.” Phytochemisty. 1984: 1587–91.

Picão Preto (Bidens pilosa)
Yoshida, N., et al. "Bidens pilosa suppresses interleukin-1beta-induced cyclooxygenase-2 expression through the inhibition of mitogen activated protein kinases phosphorylation in normal human dermal fibroblasts." J. Dermatol. 2006; 33(10): 676-83.
Chiang, Y. M., et al. “Ethyl caffeate suppresses NF-kappaB activation and its downstream inflammatory mediators, iNOS, COX-2, and PGE2 in vitro or in mouse skin.” Br. J. Pharmacol. 2005 Oct; 146(3): 352-63.
Nguelefack, T. B., et al. “Relaxant effects of the neutral extract of the leaves of Bidens pilosa Linn on isolated rat vascular smooth muscle.” Phytother. Res. 2005; 19(3): 207-10.
Chang, C. L., et al. "The distinct effects of a butanol fraction of Bidens pilosa plant extract on the development of Th1-mediated diabetes and Th2-mediated air way inflammation in mice." J. Biomed. Sci. 2005; 12(1): 79-89.
Pereira, R. L., et al. “Immunosuppressive and anti-inflammatory effects of methanolic extract and the polyacetylene isolated from Bidens pilosa L.” Immunopharmacology. 1999; 43(1): 31–7.
Jager, A. K., et al. “Screening of Zulu medicinal plants for prostaglandin-synthesis inhibitors” J. Ethnopharmacol. 1996; 52(2): 95–100.
Chih, H. W., et al. “Anti-inflammatory activity of Taiwan folk medicine ‘ham-hong-chho’ in rats.” Am. J. Chin. Med. 1995; 23(3–4): 273–78.

Iporuru (Alchornea castaneifolia)
Okoye, F., et al. "Topical anti-inflammatory constituents of lipophilic leaf fractions of Alchornea floribunda and Alchornea cordifolia." Nat Prod Res. 2011 Dec;25(20):1941-9.
Lopes, F., et al. "Anti-inflammatory activity of Alchornea triplinervia ethyl acetate fraction: inhibition of Hv(2)Ov(2), NO and TNF-?." Pharm Biol. 2010 Dec;48(12):1320-7.
Kouakou-Siransy, G., et al. "Effects of Alchornea cordifolia on elastase and superoxide anion produced by human neutrophils." Pharm Biol. 2010 Feb;48(2):128-33. Okoye, F., et al. "Anti-inflammatory and membrane-stabilizing stigmastane steroids from Alchornea floribunda leaves." Planta Med. 2010 Feb;76(2):172-7.
Manga, H., et al. "Anti-inflammatory compounds from leaves and root bark of Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg." J Ethnopharmacol. 2008 Jan 4;115(1):25-9.
Manga, H.M., et al. “In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae).” J. Ethnopharmacol. 2004 Jun; 92(2-3): 209-14.
Osadebe, P. O., et al. “Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea cordifolia leaves.” J. Ethnopharmacol. 2003 Nov; 89(1):19-24.
Tona, L., et al. “Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa, Congo.” Phytomedicine. 2000 Mar; 7(1): 31-8.
Dunstan, C. A., et al. “Evaluation of some Samoan and Peruvian medicinal plants by prostaglandin biosynthesis and rat ear oedema assays.” J. Ethnopharmacol. 1997; 57: 35–56.
Ogungbamila, F. O., et al. “Smooth muscle–relaxing flavonoids from Alchornea cordifolia.” Acta Pharm. Nord. 1990; 2(6): 421–22.
Persinos-Perdue, G., et al. “Evaluation of Peruvian folk medicine by the natural products research laboratories.” Abstra. Joint Meeting American Society of Pharmacognosy and Society for Economic Botany, Boston, 1981; (5) 13

Sarsaparilla (Smilax officinalis)
Shao, B., et al. "Steroidal saponins from Smilax china and their anti-inflammatory activities." Phytochemistry. 2006 Dec 11;
Shu, X. S., et al. "The anti-inflammation effects of Smilax china ethylacetate extract in rats and mice." Zhongguo. Zhong. Yao. Za. Zhi. 2006 Feb; 31(3): 239-43.
Shu, X. S., et al. "Anti-inflammatory and anti-nociceptive activities of Smilax china L. aqueous extract." J. Ethnopharmacol. 2006 Feb; 103(3): 327-32.
Ji, W., et al. “Effects of Rebixiao granules on blood uric acid in patients with repeatedly attacking acute gouty arthritis.” Chin. J. Integr. Med. 2005 Mar; 11(1): 15-21.
Jiang, J., et al. “Immunomodulatory activity of the aqueous extract from rhizome of Smilax glabra in the later phase of adjuvant-induced arthritis in rats." J. Ethnopharmacol. 2003; 85(1): 53–9.
Ageel, A. M., et al. “Experimental studies on antirheumatic crude drugs used in Saudi traditional medicine.” Drugs Exp. Clin. Res. 1989; 15(8): 369–72.

Guaco (Mikania cordata, guaco)
Benatti, B., et al. "Effects of a Mikania laevigata extract on bone resorption and RANKL expression during experimental periodontitis in rats." J Appl Oral Sci. 2012 May-Jun;20(3):340-6.
Napimoga, M., et al. "Scientific evidence for Mikania laevigata and Mikania glomerata as a pharmacological tool." J Pharm Pharmacol. 2010 Jul;62(7):809-20.
Alves, C., et al. "Anti-inflammatory activity and possible mechanism of extract from Mikania laevigata in carrageenan-induced peritonitis." J Pharm Pharmacol. 2009 Aug;61(8):1097-104.
Freitas, T., et al. "Effects of Mikania glomerata Spreng. and Mikania laevigata Schultz Bip. ex Baker (Asteraceae) extracts on pulmonary inflammation and oxidative stress caused by acute coal dust exposure." J Med Food. 2008 Dec;11(4):761-6.
Suyenaga, E. S., et al. “Antiinflammatory investigation of some species of Mikania." Phytother. Res. 2002; 16(6): 519-23.
Ahmed, M., et al. “Analgesic sesquiterpene dilactone from Mikania cordata.” Fitoterapia. 2001 Dec; 72(8): 919-21.
Peluso, G., et al. “Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide ion production.” J. Nat. Prod. 1995; 58(5): 639-46.
Leite, M. G. R., et al. “Actividade bronchodilatora de Mikania glomerata, Justicia pectoralis e Torresea cearensis." Simposio de Plantas Medicinais do Brazil. December 1992. Curitiba. Resumos. p. 21
Oliveira, F., et al. “Caraterizacao cromatograpfica do extracto fluido de Mikania glomerata Sprengel.” Simposio de Plantas Medicinais do Brazil. December 1992. Curitiba. Resumos. p. 96
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake venom--I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz. 1991; 86 Suppl 2:203-5.



*The statements contained herein have not been evaluated
by the Food and Drug Administration. The information contained herein is intended and provided for education, research, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plants and/or formulas described herein are not intended to treat, cure, diagnose, mitigate or prevent any disease and no medical claims are made.
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