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Tamamuri is a very common and well-respected remedy for rheumatism and arthritis throughout the Amazon and in traditional medicine systems in South America.* It is also a very common remedy for syphilis, which is how it earned one of its common names, "vegetable mercury." Mercury was the leading treatment for syphilis in the late 1800s and early 1900s. . . and before we knew any better!* For more information about tamamuri (Brosimum acutifolium), please refer to the Database File for Tamamuri in the Tropical Plant Database. More information can also be found in the new Antimicrobial Guide. To see pictures of tamamuri, click here.
Traditional Uses:* for arthritis, rheumatism and rheumatoid arthritis; for general pain and inflammation (i.e.; muscle pain, injuries, headaches, etc.); for syphilis; for yeast infections (candida) and skin fungi; for gastric ulcers (H. pylori) and other gastrointestinal problems
Suggested Use:* This plant is best prepared as a decoction. Use one teaspoon of powder for each cup of water. Bring to a boil and gently boil in a covered pot for 20 minutes. Allow to cool and settle for 10 minutes and strain warm liquid into a cup (leaving the settled powder in the bottom of the pan). It is traditionally taken in 1 cup dosages 3 times daily.
For more complete instrutions on preparing herbal decoctions see the Methods for Preparing Herbal Remedies Page.
Contraindications: None known.
Drug Interactions: None known.
Third-Party Published Research*
All available third-party research on tamamuri be found at PubMed. A partial listing of the third-party published research on tamamuri is shown below:
Anti-inflammatory and PKC Inhibitory Actions:
Dos Santos, M. C., et al. "Avaliação do tratamento da artrite induzida por adjuvante completo de freund em ratos Lewis com as frações isoladas de Brosimum acutifolium." Proceedings of the XV Congresso de Iniciação Científica da UFAM. Brazil. Aug. 2003; page 223.
Dos Santos, M. C., et al. "Avaliação da toxicidade do extrato hidro-alcoólico e das frações isoladas de Brosimum acutifolium no tratamento da artrite induzida por adjuvante completo de freund em ratos Lewis." Proceedings of the XV Congresso de Iniciação Científica da UFAM. Brazil. Aug. 2003; page 222.
Takashima, J., et al. "Mururins A-C, three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity." Planta Med. 2002; 68(7): 621-625.
Aksoy, E., et al. "Protein kinase C epsilon: A new target to control inflammation and immune-mediated disorders." Int. J. Biochem. Cell Biol. 2004; 36(2): 183-8.
Cytotoxic & Antitumor Actions:
Stallings-Mann, M., et al. "A novel small-molecule inhibitor of protein kinase Ciota blocks transformed growth of non-small-cell lung cancer cells." Cancer Res. 2006 Feb; 66(3):1767-74.
Takashima, J., et al. "Brosimacutins J-M, four new flavonoids from Brosimum acutifolium and their cytotoxic activity." Planta Med. 2005 Jul;71(7):654-8.
Cohen, E. E., et al. "Protein kinase C zeta mediates epidermal growth factor-induced growth of head and neck tumor cells by regulating mitogen-activated protein kinase." Cancer Res. 2006 Jun; 66(12): 6296-303.
Monks, N. R., et al. "Anti-tumour screening of Brazilian plants." Pharma. Biol. 2002; 40(8): 603–616.
Takashima, J., et al. "Brosimacutins J-M, four new flavonoids from Brosimum acutifolium and their cytotoxic activity." Planta Med. 2005; 71(7): 654-8.
Researchers at Cornell University reported that tamamuri bark showed in vitro antibacterial actions against Bacillus and Staphylococcus in research published in 2002. This same study reported that it was also active against Helicobacter pylori as well as Candida albicans which confirms two other traditional uses of the bark: for gastric ulcers and yeast infections. They also reported that it was active against a common strain of skin fungus.
Correia, A., et al. "Amazonian plant crude extract screening for activity against multidrug-resistant bacteria."
Eur Rev Med Pharmacol Sci. 2008 Nov-Dec;12(6):369-80.
Herforth, A., et al. "Amazonian Women's Medicine: Treatments for Mycoses." Poster: Society for Economic Botany 2002 vol 56(4).
Herforth, A., et al. " Antifungal plants of the Peruvian Amazon: A survey of ethnomedical uses and biological activity." Cornel University Publication 2002
moretti, C., et al. "Identification of 5-hydroxy-tryptamine (bufotenine) in takini (Brosimumacutifolium Huber subsp. acutifolium C.C. Berg, Moraceae), a shamanic potion used in the Guiana Plateau." J Ethnopharmacol. 2006 Jun 30;106(2):198-202.
Torres, S. L., et al. "Two flavans from Brosimum acutifolium." Phytochemistry. 1997; 44(2): 347-349.
Ferrari, F., et al. "(-)-epicatechin 5-o-beta-d-xylopyranoside from Brosimopsis acutifolium." Phytochemistry. 1998; 47(6): 1165-1166.
Torres, S. L., et al. "Flavonoids from Brosimum acutifolium." Phytochemistry. 2000; 53(8): 1047-1050.
Teixeira, A. F., et al. "Structure determination by H and C NMR of a new flavan isolated from Brosimum acutifolium: 4',7-dihydroxy-8-prenylflavan." Magn. Reson. Chem. 2000: 38(4): 301-304.
Takashima, J., et al. "Acutifolins A-F, a new flavan-derived constituent and five new flavans from Brosimum acutifolium." J. Nat. Prod. 2001: 64(12): 1493-1496.
Takashima, J., et al. Brosimacutins A-I, nine new flavonoids from Brosimum acutifolium." J. Nat. Prod. 2002; 65(12): 1843-1847.
* The statements contained herein have not been evaluated
by the Food and Drug Administration. This product is
not intended to treat, cure, mitigate or prevent any disease.
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Last updated 1-2-2013