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Condurango Herb Powder
This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information on why. Click on one of the product search links in the left margin of this page to find other available products. You can also see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants in general.
Condurango is a tropical woody vine that can be found in the high mountain jungles and cloud forests between 2,000 and 3,000 m in elevation. It is indigenous to the lower slopes of the Andes in Peru, and is traditionally used there for all types of stomach conditions,* For more complete information about condurango (Marsdenia cundurango), please refer to the Database File for Condurango in the Tropical Plant Database.
Traditional Uses:* for indigestion, nausea, vomiting and stomach pain; as a bitter stomach tonic to increase appetite; for gastric ulcers; as a digestive aid to increase and stimulate digestive juices and bile; for nervous eating disorders (anorexia, etc.) Suggested Use: This plant is best prepared as an infusion (tea): Use one teaspoon of powder for each cup of water. Pour boiling water over herb in cup and allow to steep 10 minutes. Strain tea (or allow settled powder to remain in the bottom of cup) and drink warm. It is traditionally taken in 1/2 cup dosages, twice daily. For more complete instructions on preparing herbal infusions see the Methods for Preparing Herbal Remedies Page.Contraindications: One case report was published that a patient with a known latex allergy had an allergic reaction to a condurango tea. If you are allergic to latex, it is best to avoid using this plant.
Drug Interactions: None reported.
Published Research on Condurango
All available third-party research on condurango can be found at PubMed. A partial listing of the published research on condurango is shown below:
Digestive Actions:
Yamasaki, K., et al. "Studies on the effect of crude drugs on enzyme activites (IV) Influence of stomachic crude drugs on digestive enzymes." Shoyakugaku Zasshi. 1986; 40(3): 289-294.
Anti-inflammatory Actions:
Balreira, A., et al. "Uncoupling between CD1d upregulation induced by retinoic acid and conduritol-B-epoxide and iNKT cell responsiveness." Immunobiology. 2009 Aug 1.
De Las Heras, B., et al. " Antiinflammatory and antioxidant activity of plants used in traditional medicine in Ecuador." J. Ethnopharmacol. 1998; 61(2): 161-166.
Ortega, T., et al. "Anti-inflammatory activity of ethanolic extracts of plants used in traditional medicine in Ecuador." Phytother. Res. 1996: S121 -S122.
Anti-tumor Actions:
Tatsuno, S., et al. "Pregnane glycosides from the bark of Marsdenia cundurango and their cytotoxic activity." J Nat Med. 2018 Sep 24.
Saha SK, et al. "Ultra-highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro." J Integr Med. 2015 Nov;13(6):400-11.
Sourav S, et al. "Erratum: Ethanolic Extract of Marsdenia condurango Ameliorates Benzo[a]pyrene-induced Lung Cancer of Rats: Condurango Ameliorates BaP-induced Lung Cancer in Rats." J Pharmacopuncture. 2015 Jun;18(2):86-7.
Sikdar S, et al. "Anti-lung cancer potential of pure esteric-glycoside condurangogenin A against nonsmall-cell lung cancer cells in vitro via p21/p53 mediated cell cycle modulation and DNA damage-induced apoptosis." Pharmacogn Mag. 2015 May;11(Suppl 1):S73-85.
Khuda-Bukhsh et al. "Condurango 30C Induces Epigenetic Modification of Lung Cancer-specific Tumour Suppressor Genes via Demethylation." Forsch Komplementmed. 2015;22(3):172-9.
Sikdar S, et al. "Ethanolic Extract of Marsdenia condurango Ameliorates Benzo[a]pyrene-induced Lung Cancer of Rats: Condurango Ameliorates BaP-induced Lung Cancer in Rats." J Pharmacopuncture. 2014 Jun;17(2):7-17.
Sikdar S, et al. "Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer, in vitro and in vivo." Environ Toxicol Pharmacol. 2014 Jan;37(1):300-14.
Hayashi, K., et al. "Antitumor active glycosides from condurango cortex." Chem. Pharm. Bull. 1980: 1954-1958.
Takase, M., et al. "Studies on the constituents of Asclepiadaceae plants. 49. Confirmation of the structures of antitumor-active glycosides in condurango cortex. Chemical transformation of the aglycone moiety." Chem. Pharm. Bull. 1982: 2429-2432.
Hayashi, K., et al. "Further investigation of antitumor condurangoglycosides with C-18 oxygenated aglycone." Chem. Pharm. Bull. 1981: 29(9): 2725-2730. Anon. "Antitumor substances from Marsdenia cundurango." Patent 1981. Japan Kokai Tokkyo Koho 81 125,400.
Anon. "Condurango extracts and anti-tumor agents from same." Patent 1981 Japan Kokai Tokkyo Koho 81 147,721.
Anon. "Condurango glycoside EO1." Patent 1982 - Japan Kokai Tokkyo Koho 57 163,398
Mitsuhashi, H., et al. "Condurango glycoside compounds, processes for their preparation, antitumor agents comprising them and compositions." U.S. Patent no. 4,452,786 June 5, 1984.
Anti-diabetic Actions:
Simoes-Pires, C., et al. "A TLC bioautographic method for the detection of alpha- and beta-glucosidase inhibitors in plant extracts." Phytochem. Anal. 2009 Nov; 20(6): 511-5.
Wei, J., et al. "Experimental [corrected] study of hypoglycemic activity of conduritol A of stems of Gymnema sylvestre. Zhongguo. Zhong. Yao. Za. Zhi. 2008 Dec; 33(24): 2961-5.
Antimicrobial Actions (virus & bacteria):
Grange, J. M., et al. "Detection of antituberculous activity in plant extracts." J. Appl. Bacteriol. 1990; 68(6): 587-591.
May, G., et al. "Antiviral activity of aqueous extracts from medicinal plants in tissue cultures." Arzneim-Forsch. 1978: 28(1): 1-7.
Yamasaki, K., et al. "Studies on the effect of crude drugs on enzyme activites (IV) Influence of stomachic crude drugs on digestive enzymes." Shoyakugaku Zasshi. 1986; 40(3): 289-294.
Anti-inflammatory Actions:
Balreira, A., et al. "Uncoupling between CD1d upregulation induced by retinoic acid and conduritol-B-epoxide and iNKT cell responsiveness." Immunobiology. 2009 Aug 1.
De Las Heras, B., et al. " Antiinflammatory and antioxidant activity of plants used in traditional medicine in Ecuador." J. Ethnopharmacol. 1998; 61(2): 161-166.
Ortega, T., et al. "Anti-inflammatory activity of ethanolic extracts of plants used in traditional medicine in Ecuador." Phytother. Res. 1996: S121 -S122.
Anti-tumor Actions:
Tatsuno, S., et al. "Pregnane glycosides from the bark of Marsdenia cundurango and their cytotoxic activity." J Nat Med. 2018 Sep 24.
Saha SK, et al. "Ultra-highly diluted plant extracts of Hydrastis canadensis and Marsdenia condurango induce epigenetic modifications and alter gene expression profiles in HeLa cells in vitro." J Integr Med. 2015 Nov;13(6):400-11.
Sourav S, et al. "Erratum: Ethanolic Extract of Marsdenia condurango Ameliorates Benzo[a]pyrene-induced Lung Cancer of Rats: Condurango Ameliorates BaP-induced Lung Cancer in Rats." J Pharmacopuncture. 2015 Jun;18(2):86-7.
Sikdar S, et al. "Anti-lung cancer potential of pure esteric-glycoside condurangogenin A against nonsmall-cell lung cancer cells in vitro via p21/p53 mediated cell cycle modulation and DNA damage-induced apoptosis." Pharmacogn Mag. 2015 May;11(Suppl 1):S73-85.
Khuda-Bukhsh et al. "Condurango 30C Induces Epigenetic Modification of Lung Cancer-specific Tumour Suppressor Genes via Demethylation." Forsch Komplementmed. 2015;22(3):172-9.
Sikdar S, et al. "Ethanolic Extract of Marsdenia condurango Ameliorates Benzo[a]pyrene-induced Lung Cancer of Rats: Condurango Ameliorates BaP-induced Lung Cancer in Rats." J Pharmacopuncture. 2014 Jun;17(2):7-17.
Sikdar S, et al. "Condurango glycoside-rich components stimulate DNA damage-induced cell cycle arrest and ROS-mediated caspase-3 dependent apoptosis through inhibition of cell-proliferation in lung cancer, in vitro and in vivo." Environ Toxicol Pharmacol. 2014 Jan;37(1):300-14.
Hayashi, K., et al. "Antitumor active glycosides from condurango cortex." Chem. Pharm. Bull. 1980: 1954-1958.
Takase, M., et al. "Studies on the constituents of Asclepiadaceae plants. 49. Confirmation of the structures of antitumor-active glycosides in condurango cortex. Chemical transformation of the aglycone moiety." Chem. Pharm. Bull. 1982: 2429-2432.
Hayashi, K., et al. "Further investigation of antitumor condurangoglycosides with C-18 oxygenated aglycone." Chem. Pharm. Bull. 1981: 29(9): 2725-2730. Anon. "Antitumor substances from Marsdenia cundurango." Patent 1981. Japan Kokai Tokkyo Koho 81 125,400.
Anon. "Condurango extracts and anti-tumor agents from same." Patent 1981 Japan Kokai Tokkyo Koho 81 147,721.
Anon. "Condurango glycoside EO1." Patent 1982 - Japan Kokai Tokkyo Koho 57 163,398
Mitsuhashi, H., et al. "Condurango glycoside compounds, processes for their preparation, antitumor agents comprising them and compositions." U.S. Patent no. 4,452,786 June 5, 1984.
Anti-diabetic Actions:
Simoes-Pires, C., et al. "A TLC bioautographic method for the detection of alpha- and beta-glucosidase inhibitors in plant extracts." Phytochem. Anal. 2009 Nov; 20(6): 511-5.
Wei, J., et al. "Experimental [corrected] study of hypoglycemic activity of conduritol A of stems of Gymnema sylvestre. Zhongguo. Zhong. Yao. Za. Zhi. 2008 Dec; 33(24): 2961-5.
Antimicrobial Actions (virus & bacteria):
Grange, J. M., et al. "Detection of antituberculous activity in plant extracts." J. Appl. Bacteriol. 1990; 68(6): 587-591.
May, G., et al. "Antiviral activity of aqueous extracts from medicinal plants in tissue cultures." Arzneim-Forsch. 1978: 28(1): 1-7.
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