Dr. Duke's
Phytochemical and Ethnobotanical Databases

Chemicals and their Biological Activities in: Drimys winteri FORSTER & FORSTER f. (Winteraceae) -- Winter's Bark

Chemicals

CARYOPHYLLENE Bark: DUKE1992A

Aldose-Reductase-Inhibitor PJB1(3):238 ; Antiacne PJB1(3):238 ; Antiasthmatic LAF ; Antibacterial JAF40:2329 ; Anticariogenic MIC=>1,600 ug/ml JAF41:1103 ; Antiedemic CPB38:2283 ; Antifeedant 500 ppm TOX ; Antiinflammatory IC50=100 uM CPB38:2283 ; Antispasmodic DUKE1992B ; Antistaphylococcic JAR10:7 ; Antistreptococcic PJB1(3):238 ; Antitumor JNP55:999 ; Candidicide JAR10:7 ; FLavor FEMA 20-200 ARC ; Fungicide JAR10:7 ; Insectifuge 382 ; Irritant ZEB ; Perfumery M11 ; Pesticide DUKE1992B ; Sedative JAR10:7 ; Termitifuge 382

CELLULOSE Wood 353,000 - 366,000 ppm DUKE1992A

Hemostat M29

CINEOLE Bark: DUKE1992A

No activity reported.

CONFERTIFOLIN Bark: DUKE1992A

No activity reported.

CRYPTOMERIDOL Plant: DUKE1992A

Antilithic AEH ; Antispasmodic AEH ; Coronary-Dilator AEH

DIHYDROQUERCETIN Leaf: DUKE1992A

Antimutagenic ID50=50-100 nM PCF:13 ; Antioxidant PC27:971 ; Antithiamin PCF:54

DRIMENOL Plant: DUKE1992A

No activity reported.

DRIMINE Bark: DUKE1992A

No activity reported.

DRIMOL Leaf: DUKE1992A

No activity reported.

EO Bark 10,000 ppm; DUKE1992A

No activity reported.

EUGENOL Bark: DUKE1992A

Allergenic M&R488 ; Analgesic M11 ; Anesthetic 200-400 PR4:93 ; Antiaggregant IC50=0.3 uM PR4:93 ; Antiarachidonate PJB1(2):269 ; Antibacterial 500 ppm VAL ; Anticonvulsant JBH ; Antiedemic 100 PR4:95 ; Antifeedant 382 ; Antiinflammatory (11 uM) IC~97=1,000 uM PHM7:7 ; Antimitotic JBH ; Antimutagenic EMP6:235 ; Antinitrosating PCF-I:200 ; Antioxidant 10 uM HHM7:7 IC65=30 ppm PCF:219 ; Antiprostaglandin 11 uM PM186:1986 IC50=9.2 mM POP:150 ; Antipyretic 3 ml/man/day DUKE1992B ; Antiradicular EC50=2 ul/l PMP22:233 ; Antiseptic 3 ml/man/day DUKE1992B ; Antispasmodic LAF ; Antithromboxane LRN-JUL87 ; Antitumor JNP55:999 ; Antiulcer DUKE1992B ; Apifuge 382 ; Calcium-Antagonist IC50=200 uM gpg J14432 IC50=224 uM LAB58 ; Cancer-Preventive 525 ; Candidicide PR4:93 ; Carcinogenic? NIG ; Carminative JPP46:16 ; Choleretic DUKE1992B ; CNS-Depressant JBH ; COX-1-Inhibitor IC97=1,000 uM PHM7:7 ; COX-2-Inhibitor IC>97=1,000 uM HHM7:7 ; Cytochrome-P450-Inhibitor PIZ ; Cytotoxic 25 ug/mL PR4:93 ; Dermatitigenic M&R489 ; Enterorelaxant JAR4:22 ; FLavor FEMA 10-500 ARC ; Fungicide PMP23:60 ; Hepatoprotective 100 ppm TOXICOLOGY107:39 ; Herbicide PMP23:60 ; Insecticide LAF ; Insectifuge 382 ; Irritant; Juvabional 382 ; Larvicide JE26:72 ; Motor-Depressant BVC:162 ; Nematicide MLC=2,000 ug/ml SZ44:183 ; Neurotoxic RJH ; Perfumery ARC ; Pesticide DUKE1992B ; Prostaglandin-Synthesis-Inhibitor 1 mM rbt GPH27:629 IC50=9.2 uM; Sedative; Trichomonicide LD100=300 ug/ml FT67:279 ; Trichomonistat IC50=10 ug/ml NIG ; Trypsin-Enhancer LRN-DEC93 ; Ulcerogenic PR4:93 ; Vermifuge DUKE1992B

FUEGINE Bark: DUKE1992A

No activity reported.

FURTONOLIDE Bark: DUKE1992A

No activity reported.

HEMICELLULOSE Wood 353,000 - 366,000 ppm DUKE1992A

No activity reported.

ISOTADEONAL Plant: DUKE1992A

No activity reported.

KAEMPFEROL Leaf: DUKE1992A

11B-HSD-Inhibitor CPT59:62 ; 5-Lipoxygenase-Inhibitor IC50 (uM)=20; Aldose-Reductase-Inhibitor 100 uM JBC8:211 ; Antiaggregant 30 uM; Antiallergic RWG122 ; Antibacterial 20 ug/ml; Anticancer JAF47:397 ; Antifertility 250 mg/kg day/60 days/orl rat PMP23:193 ; Antigingivitic 20 ug/ml JNP59:987 ; Antihistaminic 411 ; Antiimplantation JE32:175 ; Antiinflammatory 20 mg/kg DUKE1992B 200 mg/kg ipr rat DUKE1992B ; Antileukemic IC50=3.1 ug/ml LS55:1061 ; Antilymphocytic JBH ; Antimutagenic ID50=10-40 nM PCF ; Antioxidant IC50=40 uM PC27:972 ; Antiperiodontic 20 ug/ml JNP59:987 ; Antiplaque JNP59:987 ; Antiradicular 7 x quercetin; Antiseptic 20 ug/ml JNP59:987 ; Antiserotonin 200 mg/kg ipr rat FT63(1):3 ; Antispasmodic 411 ; Antitumor JAF47:397 ; Antitumor-Promoter CPB38:774 ; Antiulcer 50-200 mg/kg ipr rat; Antiviral; Apoptotic 60 uM PMID10673981 ; Aromatase-Inhibitor IC12=1 uM/l JMF2:235 ; cAMP-Phosphodiesterase-Inhibitor AFR27:180 ; Cancer-Preventive 525 ; Carcinogenic ZUL ; Choleretic LAF ; COX-2-Inhibitor COX:50 ; Cyclooxygenase-Inhibitor IC50 (uM) =20; Diaphoretic? LRN-DEC90 ; Diuretic BJP3:10 ; Estrogenic EC50=0.1-25 uM/l JMF2:227 EC50=0.56 uM PMID10923837 ; HIV-RT-Inhibitor IC50=50-150 ug/ml JNP54:142 ; Hypotensive FT1990:508 ; Inotropic PMID10404425 ; Iodothyronine-Deiodinase-Inhibitor JBH ; Lipoxygenase-Inhibitor JBH ; MAO-Inhibitor PMID10813558 ; Mutagenic JBH ; Natriuretic BJP3:10 ; Neuroprotective PMID10813558 ; PAF-Inhibitor FT67:548 ; Pesticide DUKE1992B ; Protisticide PR13:102 ; Quinone-Reductase-Inducer 3 uM; Teratologic DUKE1992B ; Topoisomerase-I-Inhibitor TIH14:223 ; Topoisomerase-II-Inhibitor IC50=8.1 ug/ml JNP58:217 ; Uterotrophic EC50=0.1-25 uM/l JMF2:227 ; Vasodilator JAFC48:220

L-3-BETA-ACETOXYDRIMENIN Leaf: DUKE1992A

No activity reported.

L-PINENE Bark: DUKE1992A

No activity reported.

LIGNIN Wood 277,000 - 279,000 ppm DUKE1992A

Antibacterial DUKE1992B ; Anticancer AFR27:209 ; Anticoronary AFR27:209 ; Antidiarrheic M29 ; AntiHIV DUKE1992B ; Antinitrosaminic AFR27:209 ; Antioxidant AFR27:209 ; Antitumor AFR27:209 ; Antiviral CPB38:3033 ; Chelator AFR27:209 ; Hypocholesterolemic AFR27:209 ; Laxative AFR27:209 ; Pesticide DUKE1992B

MANNITOL Bark: DUKE1992A

Allergenic M29 ; Anthelminthic WOI ; Antiglaucomic MAR ; Antiinflammatory WOI ; Antimutagenic DUKE1992B ; Antinephritic M29 ; Antioxidant 505 ; Antiradicular PCF:146 ; AntiReye's M29 ; Antispasmodic WOI ; Diuretic M11 ; Emetic MAR ; Flatugenic M29 ; Laxative M29 ; Nephrotoxic M29 ; Pesticide DUKE1992B ; Sweetener JBH

QUERCETIN Leaf: DUKE1992A

11B-HSD-Inhibitor CPT59:62 ; 5-Lipoxygenase-Inhibitor IC50 (uM)=4; Aldose-Reductase-Inhibitor 100 uM 4 ug/ml SKN43:99 IC50=0.344 uM ZZZ18:623 IC50=0.84 ug/ml cow CPB43:1385 ; Allelochemic IC82=1 mM 438 ; Allergenic JBH ; Analgesic FT63(3):197 ; Antiaggregant 30 uM JAF45:4505 IC50=55 uM EMP5:333 ; Antiallergic IC50=14 uM JIM127:546 ; Antianaphylactic PR4(5):201 ; Antiasthmatic; Antiatherosclerotic PMID11020457 ; Antibacterial JBH ; Anticarcinomic (Breast) IC50=1.5 uM MED ; Anticariogenic ID50=120 ug/ml JAF48:5666 ; Anticataract PM56(3):258 ; Anticolitic 400 mg/man/3x/day PAM ; AntiCrohn's PAM ; Antidermatitic PAM ; Antidiabetic; Antielastase IC50=0.8 ug/ml DUKE1992B ; Antiencephalitic EMP5:199 ; Antiescherichic PMID10857921 ; Antiestrogenic; Antifeedant IC52=<1,000 ppm diet 438 ; Antifibrosarcomic JAF45:4505 ; Antiflu V&D ; Antigastric RR21:85 ; Antigonadotropic JBH ; AntiGTF ID50=120 ug/ml JAF48:5666 ; Antihepatotoxic PM56(2):171 ; Antiherpetic PAM ; Antihistaminic IC50=<10 uM; AntiHIV JNP60(9):884 ; Antihydrophobic V&D ; Antihypertensive KCH ; Antiinflammatory (20 mg/kg) 150 mg/kg FT5:1990 ; Antileukemic 5.5-60 uM BO2 IC50=10 uM EMP5:225 IC50=>10 ug/ml LS55:1061 ; Antileukotriene PAM ; Antilipoperoxidant IC67=50; Antimalarial IC50=1-6.4 ug/ml MPT ; Antimelanomic; Antimutagenic ID50=2-5 nM PCF ; Antimyocarditic EMP5:199 ; Antinitrosaminic PAL:339 ; Antioxidant 4.7 x Vit. E BO2 ED50=2.3 uM PR14:93 IC96=300 ppm PCF ; Antipancreatitic JNU ; Antiperiodontal PAM ; Antipermeability DUKE1992B ; Antiperoxidant PM57:A110 ; Antipharyngitic PAM ; Antiplaque PAM ; AntiPMS 500 mg/2x/day/wmn PAM ; Antipodriac PAM ; Antipolio PAM ; Antiproliferant JNM7:51 ; Antiprostanoid PCF:51 ; Antiprostatitic JNU ; Antipsoriac PAM ; Antiradicular IC50=4.6 uM PM56(6):695 ; Antispasmodic; Antistreptococcic ID50=120 ug/ml JAF48:5666 ; Antithiamin PCF:69 ; Antithrombic PAL:339 ; Antitumor 10 uM; Antitumor (Bladder) JNM7:51 ; Antitumor (Breast) JNM7:51 ; Antitumor (Colon) JAF45:4505 ; Antitumor (Lung) PMID10918203 ; Antitumor (Ovary) JNM7:51 ; Antitumor (Skin) 20 uM BO2 ; Antitumor-Promoter PAM ; Antiviral IC50=10 uM; Apoptotic 20-60 uM; ATPase-Inhibitor NIG ; Bacteristat 10 mg/ml QRNM(SUMMER):91 ; Bradycardiac KCH ; Calmodulin-Antagonist PAM ; cAMP-Phosphodiesterase-Inhibitor PAM ; Cancer-Preventive 525 ; Candidicide PMID10857921 ; Capillariprotective M11 ; Carcinogenic 40,000 ppm (diet) mus NIG ; Catabolic AFR27:173 ; COMT-Inhibitor QRNM1997:293 ; Copper-Chelator PR14:93 ; COX-2-Inhibitor <40 uM BO2 ; Cyclooxygenase-Inhibitor PCF:49 ; Cytotoxic ED50=70 ug/ml PM56(6):677 IC82=100 ug/ml PM57:A113 ; Deiodinase-Inhibitor JNM1:10 ; Diaphoretic? LRN-DEC90 ; Differentiator 5.5 uM BO2 ; Estrogenic 10% genistein B02 ; Fungicide PMID10857921 ; Glucosyl-Transferase-Inhibitor ID50=120 ug/ml JAF48:5666 ; Hemostat KCH ; Hepatomagenic 5,000 ppm (diet) rat PCF ; Hepatoprotective FT67:200 ; HIV-RT-Inhibitor IC50=<1 ug/ml JNP53(5):1239 ; Hypoglycemic 100 mg/kg orl rat JE27:243 ; Inotropic PMID10404425 ; Insulinogenic PAM ; Juvabional 438 ; Larvistat 8,000 ppm diet 438 ; Lipoxygenase-Inhibitor IC11=1.25 mM JAF38:688 IC50=0.1-5 uM DFN:154 ; MAO-A-Inhibitor QRNM1997:293 ; Mast-Cell-Stabilizer DUKE1992B ; Metal-Chelator (Copper) PR14:93 ; MMP-9-Inhibitor 20 uM BO2 ; Mutagenic HG22:27 ; NADH-Oxidase-Inhibitor BJP3:10 ; Neuroprotective 5-25 uM PMID11030720 ; Ornithine-Decarboxylase-Inhibitor <10 uM; P450-Inducer 5 uM FNF ; P450-Inhibitor 50-100 uM FNF ; Pesticide DUKE1992B ; Phospholipase-Inhibitor BJP3:10 ; Prostaglandin-Synthesis-Inhibitor 40 ug/ml PR11:281 ; Protein-Kinase-C-Inhibitor PCF:14 ; PTK-Inhibitor 0.4-24 uM BO2 ; Quinone-Reductase-Inducer 13 uM 6 uM CLE120:213 ; Teratologic DUKE1992B ; Topoisomerase-I-Inhibitor IC50=12.8 ug/ml IC50=42 uM BO2 ; Topoisomerase-II-Inhibitor IC50=1-6.9 ug/ml IC50=23-40 uM BO2 ; Tumorigenic 0.1% diet orl rat/yr 505 ; Tyrosine-Kinase-Inhibitor EMP6:170 ; Vasodilator; Xanthine-Oxidase-Inhibitor IC50=>0.4 ug/ml CPB38:1772

RHAMNOSE Plant: DUKE1992A

No activity reported.

TADEONOL Plant: DUKE1992A

No activity reported.

TANNIC-ACID Plant: DUKE1992A

Aldose-Reductase-Inhibitor IC50=1.8 ug/ml CPB37:1662 ; Allergenic M&R304 ; Antianacarditic (Rhus) AHP156 ; Antibacterial DUKE1992B ; Anticariogenic JD23:101 ; Anticolitic DUKE1992B ; Antidecubitic DUKE1992B ; Antidermatotic AHP156 ; Antidiarrheic AHP156 ; Antidote For Heavy Metals M11 ; Antidysenteric KCH ; Antiencephalitic V&D ; Antienteritic V&D ; Antifeedant 2-4% diet AFR27:195 ; Antigargantitic AHP156 ; Antigingivitic AHP156 ; Antihemorrhoidal M29 ; Antiherpetic CPB38:3032 ; AntiHIV IC90=200 ug/ml JNP54:152 ; Antimutagenic EMP6:235 ; Antinitrosaminic AFR27:217 ; Antiobesity (Antinutrient) KCH ; Antiophidic FT65(2):101 ; Antioxidant IC56=30 ppm PCF:218 ; Antipharyngitic DUKE1992B ; Antipolio V&D ; Antirhinitic DUKE1992B ; Antiseptic 411 ; Antistomatitic DUKE1992B ; Antitonsilitic AHP156 ; Antiulcer KCH ; Antiviral AVR14:323 ; Astringent 411 ; Cytotoxic 15 ug CPB38:3032 ; Detoxicant KCH ; Emetic M29 ; FLavor FEMA 1-1,000 ARC ; Hemostat M11 ; Hepatotoxic KCH ; Immunostimulant TEA ; Pesticide DUKE1992B

VALDIVIOLIDE Bark: DUKE1992A

No activity reported.

WINTERIN Bark: DUKE1992A

No activity reported.

References

382: Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.

411: Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.

438: Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.

505: Jim Duke's personal files.

525: Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

AEH: De Smet, P.A.G.M., Keller, K., Hansel, R. and Chandler, R.F., eds. 1993. Adverse Effects of Herbal Drugs 2. Springr-Verlag, Berlin. 348pp.

AFR27:173: Jim Duke's personal files

AFR27:180: Jim Duke's personal files

AFR27:195: Jim Duke's personal files

AFR27:209: Jim Duke's personal files

AFR27:217: Jim Duke's personal files

AHP156: Jim Duke's personal files

ARC: Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Note: Most ARC numerical data were in mg/dl. I know of no other plant where zinc is more prevalent than other minerals and protein. These data should be viewed as suspect.

AVR14:323: Antiviral Research, 14: 323.

B02: Jim Duke's personal files

BJP3:10: Jim Duke's personal files

BO2: Jim Duke's personal files

BVC:162: Buchbauer et al, e.g.Buchbauer et al,1993.Therapeutic properties of essential oils and fragrances. Chap.12 in Teranishi,R, Buttery,R.G and Sugisawa,H. Eds. Bioactive Volatile Compounds from Plants. ACS Symposium Series 525. Amer. Chem. Soc., Washington DC

CLE120:213: Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.

COX:50: Jim Duke's personal files

CPB37:1662: Sawada, H., Hamatake, M., Hara, A., Nakagawa, M., Nakayama, T. 1989. Inhibition of Human Placenta Aldose Reductase by Tannic Acid. Chem Pharm Bull, 37(6): 1662-1664.

CPB38:1772: Chem. & Pharm. Bull. 38: 1772.

CPB38:2283: Shimizu,*M., et al. 1990. Anti-inflammatory Constituents of Topically Applied Crude Drugs. IV.1) Constituents and Anti-inflammatory Effect of Paraguayan Crude Drug "Alhucema" (Lavandula latifolia Vill.)2). Chem. Pharm. Bull. 38(8): 2283-2284, 1990.

CPB38:3032: Jim Duke's personal files

CPB38:3033: Jim Duke's personal files

CPB38:774: Yasukawa, K., Takido, M., Takeuchi, M., Sato, Y., Nitta, K., and Nakagawa, S. 1989. Inhibitory Effects of Flavonol Glycosides on 12-O-Tetradecanoylphorbol-13-acetate-Induced Tumor Promotion. Chem. Pharm. Bull. 38(3): 774-776, 1990.

CPB43:1385: Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387

CPT59:62: Jim Duke's personal files

DFN:154: Jim Duke's personal files

DUKE1992A: Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.

EMP5:199: Economic & Medicinal Plant Research, 5: 199.

EMP5:225: Economic & Medicinal Plant Research, 5: 225.

EMP5:333: Economic & Medicinal Plant Research, 5: 333.

EMP6:170: Economic & Medicinal Plant Research, 6: 170.

EMP6:235: Economic & Medicinal Plant Research, 6: 235.

FNF: Father Nature's Farmacy: The aggregate of all these three-letter citations.

FT1990:508: Jim Duke's personal files

FT5:1990: Fitoterapia No.5-1990.

FT63(1):3: Jim Duke's personal files

FT63(3):197: Jim Duke's personal files

FT65(2):101: Jim Duke's personal files

FT67:200: Jim Duke's personal files

FT67:279: Jim Duke's personal files

FT67:548: Jim Duke's personal files

GPH27:629: Chen, S. J., Wang, M. H., Chen, I. J. 1996. Antiplatelet and Calcium Inhibitory Properties of Eugenol and Sodium Eugenol Acetate. Gen Pharmacol, 27(4): 629-633.

HG22:27: Jim Duke's personal files

HHM7:7: Jim Duke's personal files

J14432: Jim Duke's personal files

JAF38:688: Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690.

JAF40:2329: Jim Duke's personal files

JAF41:1103: Muroi, H. and Kubo, I. 1993. Combination Effects of Antibacterial Compounds in Green Tea Flavor against Streptococcus mutans. J. Agric. Food Chem. 41: 1102-1105.

JAF45:4505: Jim Duke's personal files

JAF47:397: Jim Duke's personal files

JAF48:5666: Jim Duke's personal files

JAFC48:220: Jim Duke's personal files

JAR10:7: Jim Duke's personal files

JAR4:22: J. Aromatherapy 4: 22.

JBC8:211: Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213.

JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

JD23:101: Jim Duke's personal files

JE26:72: Jim Duke's personal files

JE27:243: Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989.

JE32:175: Jim Duke's personal files

JIM127:546: Jim Duke's personal files.

JMF2:227: Journal of Medicinal Food 2: 227.1999.

JMF2:235: Journal of Medicinal Food 2: 235.1999.

JNM1:10: Jim Duke's personal files.

JNM7:51: Jim Duke's personal files

JNP53(5):1239: Nakane, H., Fukushima, M., and Ono*, K. Differential Inhibition Of Reverse Transcriptase And Various DNA Polymerases By Digallic Acid And Its Derivatives. Journal of Natural Products, 53(5): 1234-1240, 1990.

JNP54:142: Garcia, J., Morin,* C., Nyasse, B., Sondengam, B-L., Tchouankeu, J-C., and Tsamo, E. Complete Structural Assignments Of An Ergosterol Derivative From Entandrophragma utile. Journal of Natural Products, 54(1): 136-142, 1991.

JNP54:152: Tan, G.T., Pezzuto, J.M., Kinghorn,* A.D., Hughes, S.H. Evaluation Of Natural Products As Inhibitors Of Human Immunodeficiency Virus Type 1 (HIV-1) Reverse Transcriptase. Journal of Natural Products, 54(1): 143-154, 1991.

JNP55:999: Zheng, G-Q., Kenney, P.M., and Lam, L.K.T. Sesquiterpenes From Clove (Eugenia caryophyllata) As Potential Anticarcinogenic Agents. Journal of Natural Products 55(7): 999-1003, 1992.

JNP58:217: Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225.

JNP59:987: Jim Duke's personal files

JNP60(9):884: Jim Duke's personal files

JNU: Jim Duke's personal files

JPP46:16: Yamamoto, A., Umemori, S., and Muranishi, S. 1993. Absorption Enhancement of Intrapulmonary Administered Insulin by Various Absorption Enhancers and Protease Inhibitors in Rats. J. Pharm. Pharmacol. 46: 14-18, 1994.

KCH: Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.

LAB58: Jim Duke's personal files

LAF: Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.

LRN-DEC90: Lawrence Review of Natural Products, Dec-90.

LRN-DEC93: Lawrence Review of Natural Products, Dec-93.

LRN-JUL87: Lawrence Review of Natural Products, Jul-87.

LS55:1061: Life Sciences 55: 1061.

M&R304: Jim Duke's personal files

M&R488: Jim Duke's personal files

M&R489: Jim Duke's personal files

M11: Merck 11th Edition

M29: Martindale's 29th

MAR: Martindale's 28th

MED: Medline (post 1990 searches filed in my computer)

MPT: Medicinal and Poisonous Plants of the Tropics. Leeuwenberg, A.J.M., ed. Pudoc, Wageningen. 1987.

NIG: Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.

PAL:339: Jim Duke's personal files

PAM: Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).

PC27:971: Jim Duke's personal files

PC27:972: Jim Duke's personal files

PCF: Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.

PCF-I:200: Jim Duke's personal files

PCF:13: Maga, J.A. Contribution of Phenolic Compounds to Smoke Flavor. Phenolic Compounds in Food and Their Effects on Health, Ch.13.

PCF:14: Naim, M., Zehavi, U., Nagy, S., and Rouseff, R.L. Hydroxycinnamic Acids as Off-Flavor Precursors in Citrus Fruits and Their Products. Phenolic Compounds in Food and Their Effects on Health, Ch.14.

PCF:146: Jim Duke's personal files

PCF:218: Jim Duke's personal files

PCF:219: Jim Duke's personal files

PCF:49: Jim Duke's personal files

PCF:51: Jim Duke's personal files

PCF:54: Pratt, D.E. Natural Antioxidants from Plant Material. Phenolic Compounds in Food and Their Effects on Health, Ch.5.

PCF:69: Phenolic Compounds in Food and Their Effects on Health, 69.

PHM7:7: Jim Duke's personal files

PIZ: Pizzorno, J. 1998. Total Wellness. Prima Health, a division of Prima.

PJB1(2):269: Jim Duke's personal files

PJB1(3):238: Jim Duke's personal files

PM186:1986: Jim Duke's personal files

PM56(2):171: Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. 1989. Tert-Butyl Hydroperoxide-Induced Injury in Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs. Planta Medica 56(2): 171-173, 1990.

PM56(3):258: Jim Duke's personal files

PM56(6):677: Matsukawa, Y., et al. The Effect of Quercetin and Other Flavonoids on Cell Cycle Progresssion and Growth of Human Gastric Cancer Cells. Planta Medica, 56(6): 677, 1990.

PM56(6):695: Planta Medica, 56(6): 695, 1990.

PM57:A110: Planta Medica, 57: A110, 1991.

PM57:A113: Planta Medica, 57: A113, 1991.

PMID10404425: Jim Duke's personal files

PMID10673981: Jim Duke's personal files

PMID10813558: Jim Duke's personal files

PMID10857921: Jim Duke's personal files

PMID10918203: Jim Duke's personal files

PMID10923837: Jim Duke's personal files

PMID11020457: Jim Duke's personal files

PMID11030720: Jim Duke's personal files

PMP22:233: Jim Duke's personal files

PMP23:193: Kumar, P., Dixit*, V.P., and Khanna, P. Antifertility Studies of Kaempferol: Isolation and Identification from Tissue Culture of some Medicinally Important Plant Species. Plantes medicinales et phytotherapie, 23: 193-201, 1989.

PMP23:60: Jim Duke's personal files

POP:150: Jim Duke's personal files

PR11:281: Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.

PR13:102: Meckes, M., Calzada, F., Tapia-Contreras, A., Cedillo-Rivera, R. 1999. Antiprotozoal Properties of Helianthemum glomeratum. Phytotherapy Research, 13(2): 102-105.

PR14:93: Seidel, V., Verholle, M., Malard, Y., Tillequin, F., Fruchart, J-C., Duriez, P., Bailleul, F., Teissier, E. 2000. Phenylpropanoids from Ballota nigra L. Inhibit in vitro LDL Peroxidation. Phytotherapy Research, 14(2): 93-98.

PR4(5):201: Meli, R., Autore, G., Di Carlo, G., Capasso, F. Inhibitory Action of Quercetin on Intestinal Transit in Mice. Phytotherapy Research 4(5): 201, 1990.

PR4:93: Phytotherapy Research, 4: 93.

PR4:95: Phytotherapy Research, 4: 95.

QRNM(SUMMER):91: Jim Duke's personal files

QRNM1997:293: Jim Duke's personal files

RJH: R.J. Hixtable (Huxtable, R.J. (as T. Max). 1992. This and That:The Essential Pharmacology of Herbs and Spices. Tips 13:15-20 Huxtable, R.J. 1992b. The Myth of Benficent Nature. The Risk of Herbal Preparations. Anns. Intern. Med. 117(2):165-6; Huxtable, R.

RR21:85: Rastitel'nye Resursy, 21: 85.

RWG122: Jim Duke's personal files

SKN43:99: Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.

SZ44:183: Shoyakugaku Zasshi, 44: 183.

TEA: McKenna, D. J., Hughes, K., and Jones, K. 2000. Green Tea Monograph. Alternative Therapies, 6(3): 61-82.

TIH14:223: Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.

TOX: Keeler, R.F. and Tu, A.T. eds. 1991. Toxicology of Plant and Fungal Compounds. (Handbook of Natural Toxins Vol. 6) Marcel Dekker, Inc. NY. 665 pp.

TOXICOLOGY107:39: Jim Duke's personal files

V&D: Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.

VAL: Valnet, J. 1982. The Practice of Aromatherapy. Translated from the 1980 French Edition by Robin Campbell and Libby Houston. Destiny Books, New York. 279 pp.

WOI: ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.

ZEB: Zebovitz, T. C. Ed. 1989. Part VII. Flavor and Fragrance Substances, in Keith L. H. and Walters, D.B., eds. Compendium of Safety Data Sheets for Research and Industrial Chemicals. VCH Publishers, New York. 3560-4253.

ZUL: Hutchings, A, Scott, AH, Lewis, G, and Cunningham, A. 1996. Zulu Medicinal Plants. An inventory. University of Natal Press, Pietermaritzburg. 450 pp.

ZZZ18:623: Mao, X. M., Zhang, J. Q. 1993. Inhibition of Aldose Reductase by Extracts of Chinese Herbal Medicine. Zhongguo Zhongyao Zazhi , 18(10): 623-624.

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