Agricultural Research Service - ARS

Dr. Duke's
Phytochemical and Ethnobotanical Databases

Chemicals and their Biological Activities in: Erythrina crista-galli L. (Fabaceae) -- Cockspur Coral Tree


ALKALOIDS Seed 24,000 - 45,300 ppm DUKE1992A
No activity reported.

ARACHIDIC-ACID Seed 5,345 ppm; DUKE1992A
No activity reported.

CNS-Depressant DUKE1992B ; Curarimimetic DUKE1992B ; Hypnotic JBH ; Hypotensive JBH ; Respiradepressant JBH

No activity reported.

No activity reported.

No activity reported.

No activity reported.

EICOSENOIC-ACID Seed 15,000 ppm; DUKE1992A
No activity reported.

Antiseptic (1-2 ug/ml) PC29(6):2005 50-100 ug/ml PC29(6):2005 ; Pesticide DUKE1992B

Neuroparalytic DUKE1992B

Neurotoxic JBH

Anticonvulsant IWU ; CNS-Depressant IWU ; Hydrocholerectic IWU ; Myorelaxant IWU ; Neuroparalytic DUKE1992B

Anticonvulsant IWU ; CNS-Depressant IWU ; Hydrocholerectic IWU ; Myorelaxant IWU ; Neuroparalytic DUKE1992B

Anticonvulsant IWU ; CNS-Depressant IWU ; Hydrocholerectic IWU ; Myorelaxant IWU ; Neuroparalytic DUKE1992B

Anticonvulsant IWU ; CNS-Depressant IWU ; Hydrocholerectic IWU ; Myorelaxant IWU ; Neuroparalytic IWU

Neuroparalytic DUKE1992B

No activity reported.

No activity reported.

No activity reported.

FAT Seed 167,000 ppm; DUKE1992A
No activity reported.

Abortifacient 52 ; Aldose-Reductase-Inhibitor IC50=10 uM; Alpha-Reductase-Inhibitor IC50=35 uM JEN147:295 ; Antiaggregant 1-10 ug/ml MED ; Antiangiogenic 150 uM PNA90:2693 ; Antiatherosclerotic JMF2:163 ; Anticancer (Breast) IC50=2.6-6.7 ug/ml DAI56(4):2001 ; Anticarcinomic (Breast) IC50=?640 uM MED ; Anticlimacteric JAD ; Antiendoccytotic 100 ug/ml MED ; Antiestrogenic OI8:274 ; Antifertility DUKE1992B ; Antihemolytic JLI ; Antiimplantation JE32:175 ; Antiinflammatory JMF2:179 ; Antiischemic MED ; Antileukemic >50 ug/ml (185 uM) IC50=0.010 ug/ml LS55:1061 ; Antileukotriene IC50=10-15 uM MED ; Antilymphomic JNP7:51 ; Antimelanomic MED ; Antimicrobial EEB26:65.1986 ; Antimitogenic IC50=12 uM PNA90:2693 ; Antimutagenic ID50=50-100 nM PCF:13 ; Antineuroblastomic JNP7:51 ; Antiosteoporotic OI8:274 ; Antioxidant PCF:64 ; Antiproliferative 5-45 uM PNA90:2693 ; Antiprostatadenomic 8-27 ug/ml MED ; Antiprostatitic IC50=35 uM JEN147:295 ; Antispasmodic IC50=34 uM PM58:314 ; Antitumor (Breast) JNP7:51 ; Antitumor (GI) JNP7:51 ; Antitumor (Ovary) JNP7:51 ; Antitumor (Prostate) JNP7:51 ; Antitumor (Stomach) JNP7:51 ; Antiulcer? JLI ; Antiviral OI8:274 ; Apoptotic BOI ; Aromatase-Inhibitor IC30=1 uM/l JMF2:235 ; Calcium-Antagonist 50 uM gpg K26820 ; Cancer-Preventive 525 ; Cardioprotective JMF2:163 ; Catechol-O-Methyltransferase-Inhibitor JLI ; Cytotoxic >50 ug/ml (185 uM) MED IC89=10 ug/ml PM57:A113 ; DOPA-Decarboxylase-Inhibitor JLI ; Estrogen-Agonist 0.1-1 uM/l JMF2:139 ; Estrogenic EC50=0.1-25 uM/l; Flatulent RWG30 ; Fungicide 2.5 mM PC38:599 ED50=50->100 JLI ; Fungistat IC34=200 uM PC29(3):802 ; Histidine-Kinase-Inhibitor IC50=110 uM MED ; Hypocholesterolemic ED50=0.5 mg/kg JSB59:155 ; Lipase-Inhibitor; MAO-Inhibitor IC50=60-140 uM CPB39:1238 IC50=95 FPC2:140 ; MDR-Inhibitor 200 uM BP53:89 ; NADH-Ubiquinone-Oxidoreductase-Inhibitor PNA95(7):3380 ; Natriuretic JMF3/4:257 ; Ornithine-Decarboxylase-Inhibitor PNA95(7):3380 ; Peroxidase-Inhibitor JBH ; Pesticide DUKE1992B ; Phytoalexin NIG ; Pituitary-sensitizer MED ; PTK-Inhibitor 10-100 uM BOI ; Quinone-Reductase-Inducer IC50=4.6 ug/ml; Topoisomerase-I-Inhibitor 1-10 ug/ml BBR157:183 IC50=250 ppm; Topoisomerase-II-Inhibitor 2-7.5 ug/ml 20 uM CR49:5111 IC50=1-150 uM IC50=30 ug/ml JNP58:217 ; Topoisomerase-II-Poison JMF2:167 ; Trypanosomastat MED ; Tyrosine-Kinase-Inhibitor; Uterotrophic EC50=0.1-25 uM/l ED50=0.5 mg/kg JSB59:155

HYPAPHORINE Seed 21,000 - 29,000 ppm DUKE1992A
Antifeedant JBH ; Convulsant; Pesticide DUKE1992B ; Tetanic HDN

LINOLEIC-ACID Seed 31,560 ppm; DUKE1992A
5-Alpha-Reductase-Inhibitor PMID10830511 ; Antianaphylactic EMP6:189 ; Antiarteriosclerotic JE26:80 ; Antiarthritic EMP6:189 ; Anticoronary JBH ; Antieczemic EMP6:189 ; Antifibrinolytic EMP1:53 ; Antigranular DUKE1992B ; Antihistaminic EMP6:189 ; Antiinflammatory IC50=31 uM; Antileukotriene-D4 POP:153 ; Antimenorrhagic PAM ; AntiMS EMP6:189 ; Antiprostatitic PAM ; Cancer-Preventive 525 ; Carcinogenic SN146:421 ; Hepatoprotective DUKE1992B ; Hypocholesterolemic GAS ; Immunomodulator EMP6:189 ; Insectifuge 382 ; Metastatic SN146:421 ; Nematicide NIG

MYRISTIC-ACID Seed 3,175 ppm; DUKE1992A
Cancer-Preventive 525 ; Cosmetic JBH ; Hypercholesterolemic GAS ; Lubricant JBH ; Nematicide NIG

OLEIC-ACID Seed 85,000 ppm; DUKE1992A
5-Alpha-Reductase-Inhibitor PMID10830511 ; Allergenic M&R495 ; Anemiagenic DUKE1992B ; Antiinflammatory IC50=21 uM POP:153 ; Antileukotriene-D4 POP:153 ; Cancer-Preventive 525 ; Choleretic 5 ml/man DUKE1992B ; Dermatitigenic M&R495 ; FLavor FEMA 1-30 ARC ; Hypocholesterolemic GAS ; Insectifuge 382 ; Irritant M11 ; Percutaneostimulant CPB38:3086 ; Perfumery ARC

PALMITIC-ACID Seed 19,000 ppm; DUKE1992A
5-Alpha-Reductase-Inhibitor PMID10830511 ; Antifibrinolytic EMP1:53 ; FLavor FEMA 1 ARC ; Hemolytic BIS ; Hypercholesterolemic GAS ; Lubricant JBH ; Nematicide NIG ; Pesticide DUKE1992B ; Soap JBH

No activity reported.

No activity reported.

PROTEIN Seed 303,000 ppm; DUKE1992A
No activity reported.

STEARIC-ACID Seed 6,500 ppm; DUKE1992A
5-Alpha-Reductase-Inhibitor PMID10830511 ; Cosmetic JBH ; FLavor FEMA 2-4,000 ARC ; Hypocholesterolemic GAS ; Lubricant JBH ; Perfumery ARC ; Propecic PMID10830511 ; Suppository JBH


382: Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.
52: Cooper-Driver, G. A., Chemical substances in plants toxic to animals, pp. 213-47 in Rechcigl, M., Jr., ed. CRC Handbook of Naturally Occurring Food Toxicants, CRC Press, Boca Raton, 1983, 339 pp.
525: Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.
ARC: Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Note: Most ARC numerical data were in mg/dl. I know of no other plant where zinc is more prevalent than other minerals and protein. These data should be viewed as suspect.
BBR157:183: Okura, A., Arakawa, H., Oka, H., Yoshinari, T., Monden, Y. 1988. Effect of Genistein on Topoisomerase Activity and on the Growth of [VAL 12]HA-RAS-Transformed NIH 3T3 Cells. Biochem Biophys Res Commun, 157: 183-189.
BIS: Bisset, N.G., ed. 1994. Herbal Drugs and Phytopharmaceuticals. CRC Press. Boca Raton, FL. 566 pp. Note: English translation of Wichtl, 1984,1989).
BOI: Jim Duke's personal files
BP53:89: Castro, A. F., Altenberg, G. A. 1997. Inhibition of Drug Transport by Genistein in Multidrug-Resistant Cell Expressing P-Glycoprotein. Biochem Pharmacol, 53(1): 89-93.
CPB38:3086: Seki, T., Toeda, C., Kawaguchi, T., Juni, K., Sugibayashi, K., and Morimoto, Y. 1990. Enhanced Transdermal Delivery of Zidovudine in Rats and Human Skin. Chem. Pharm. Bull. 38(11): 3086-3089, 1990.
CPB39:1238: Jim Duke's personal files
CR49:5111: Markovits, J., et al. 1989. Inhibitory Effects of the Tyrosine Kinase Inhibitor Genistein on Mammalian DNA Topoisomerase II. Cancer Research, 49: 5111-5117.
DAI56(4):2001: Jim Duke's personal files
DUKE1992A: Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.
DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.
EEB26:65.1986: Jim Duke's personal files
EMP1:53: Economic & Medicinal Plant Research, 1: 53.
EMP6:189: Economic & Medicinal Plant Research, 6: 189.
FPC2:140: Jim Duke's personal files
GAS: Spiller, G. A. 1996 (Spiller, G. A. Ed. 1996. CRC Handbook of Lipids in Human Nutrition. CRC Press. Boca Raton, FL. 233 pp.)
HDN: Jim Duke's personal files
IWU: Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp.
JAD: Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705.
JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
JE26:80: Jim Duke's personal files
JE32:175: Jim Duke's personal files
JEN147:295: Jim Duke's personal files
JLI: Jim Duke's personal files
JMF2:139: Journal of Medicinal Food 2: 139.1999.
JMF2:163: Journal of Medicinal Food 2: 163.1999.
JMF2:167: Journal of Medicinal Food 2: 167.1999.
JMF2:179: Journal of Medicinal Food 2: 179.1999.
JMF2:235: Journal of Medicinal Food 2: 235.1999.
JMF3/4:257: Jim Duke's personal files
JNP58:217: Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225.
JNP7:51: Jim Duke's personal files
JSB59:155: Jim Duke's personal files
K26820: Jim Duke's personal files
LS55:1061: Life Sciences 55: 1061.
M&R495: Jim Duke's personal files
M11: Merck 11th Edition
MED: Medline (post 1990 searches filed in my computer)
NIG: Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.
OI8:274: Jim Duke's personal files
PAM: Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).
PC29(3):802: Jim Duke's personal files
PC29(6):2005: Jim Duke's personal files
PC38:599: Geibel, M. 1994. Sensitivity of the Fungus Cytospora persoonii to the Flavonoids of Prunus cerasus. Phytochemistry. 38(3): 599-601. 1995.
PCF:13: Maga, J.A. Contribution of Phenolic Compounds to Smoke Flavor. Phenolic Compounds in Food and Their Effects on Health, Ch.13.
PCF:64: Phenolic Compounds in Food and Their Effects on Health, 64.
PM57:A113: Planta Medica, 57: A113, 1991.
PM58:314: Jim Duke's personal files
PMID10830511: Jim Duke's personal files
PNA90:2693: Jim Duke's personal files
PNA95(7):3380: Jim Duke's personal files
POP:153: Jim Duke's personal files
RWG30: Jim Duke's personal files
SN146:421: Science News, 146: 421.

ppm = parts per million
tr = trace

Phytochemical Database, USDA - ARS - NGRL, Beltsville Agricultural Research Center, Beltsville, Maryland
Thu May 16 17:19:42 EDT 2002

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