Dr. Duke's
Phytochemical and Ethnobotanical Databases

Chemicals and their Biological Activities in: Mirabilis jalapa L. (Nyctaginaceae) -- Four-o-clock

Chemicals

12-TRIACONSANONE Plant: JSG

No activity reported.

ARABINOSE Root: WOI

No activity reported.

BETA-AMYRIN Plant: JSG

Antiedemic IC27=40 mg/kg ipr rat DFN:159

BETA-AMYRIN-ALPHA-L-RHAMNOSYL-O-BETA-D-GLUCOSIDE Plant: JSG

No activity reported.

BETA-SITOSTEROL Plant: JSG

Androgenic DUKE1992B ; Anorexic MAR ; Antiadenomic M11 ; Antiandrogenic JE28:221 ; Antibacterial QJC28:155 ; Anticancer (Breast) PS131:95 ; Antiedemic IC54=320 mg/kg orl DFN:160 ; Antiestrogenic JE28:221 ; Antifeedant 382 ; Antifertility JE28:221 ; Antigonadotrophic JE28:221 ; Antihyperlipoproteinaemic JBH ; Antiinflammatory; Antileukemic PJB1(2):287 ; Antilymphomic PJB1(2):287 ; Antimutagenic 250 ug/mL JAFC37:1365 ; Antiophidic 2.3 mg mus EMP5:363 ; Antiprogestational JE28:221 ; Antiprostaglandin 30 mg/day/12 wks FT68(4):291 ; Antiprostatadenomic M11 ; Antiprostatitic 10-20 mg/3 x/day/orl man; Antitumor (Breast) PS131:95 ; Antitumor (Cervix) PJB1(2):287 ; Antitumor (Lung) PJB1(2):287 ; Antiviral PS75:161 ; Artemicide LC50=110 ppm PC29(5):1667 ; Cancer-Preventive 525 ; Candidicide QJC28:155 ; Estrogenic DUKE1992B ; Gonadotrophic JE28:221 ; Hepatoprotective PMP23:60 ; Hypocholesterolemic 2-6 g/man/day/orl M30 9-3,330 mg/man/day/orl MAR ; Hypoglycemic JE27:243 ; Hypolipidemic 2-6 g/day; Pesticide DUKE1992B ; Spermicide JE28:221 ; Ubiquiot JBH ; Ulcerogenic 500 mg/kg ipr rat FT63(1):3

BETA-SITOSTEROL-BETA-D-GLUCOSIDE Plant: JSG

Antileukemic DUKE1992B ; Antispasmodic 20 mg/kg MPI ; Antitumor DUKE1992B ; Hypoglycemic EMP6:158

FAT Seed 39,000 - 46,000 ppm CRC

No activity reported.

GALACTOSE Root: WOI

Sweetener 0.32 x sucrose MAR

N-HEXACOSANOL Plant: JSG

No activity reported.

PROTEIN Seed 171,000 - 181,000 ppm CRC

No activity reported.

RESIN Root 30,000 ppm; WOI

No activity reported.

TRIGONELLINE Root: WOI

Anticancer (Cervix) 411 ; Anticancer (Liver) 411 ; Antihyperglycemic IWU ; Antimigraine PMP25:56 ; Antiseptic IWU ; Antitumor (Cervix) 411 ; Antitumor (Liver) 411 ; Hypocholesterolemic DUKE1992B ; Hypoglycemic 50 mg/kg orl rat CAN 500-3,000 mg/man/day MAR ; Mutagenic MED97 ; Osmoregulator PC44:1037 ; Pesticide DUKE1992B

References

382: Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.

411: Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.

525: Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

CAN: Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.

CRC: CRC Handbook of Medicinal Herbs and/or CRC Handbook of Proximate Analyses

DFN:159: Jim Duke's personal files

DFN:160: Jim Duke's personal files

DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.

EMP5:363: Economic & Medicinal Plant Research, 5: 363.

EMP6:158: Economic & Medicinal Plant Research, 6: 158.

FT63(1):3: Jim Duke's personal files

FT68(4):291: Jim Duke's personal files

IWU: Iwu, M.M. 1993. Handbook of African Medicinal Plants. CRC Press, Boca Raton, FL 435 pp.

JAFC37:1365: Jim Duke's personal files

JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

JE27:243: Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989.

JE28:221: Malini, T. and Vanithakumari, G. 1989. Rat Toxicity Studies With B-Sitosterol. Journal of Ethnopharmacology, 28: 221-234, 1990.

JSG: J.S. Glasby Dict.Pls Containing 2ndary Metabolite. 1991.

M11: Merck 11th Edition

M30: Martindale's 30th

MAR: Martindale's 28th

MED97: Jim Duke's personal files

MPI: =ICMR(Indian Council of Medical Research).1976.Medicinal Plants of India.Vol.1.Indian Council of Med. Res.Cambridge Printing Works, New Delhi.487 pp;ICMR.1987.Medicinal Plants of India.Vol.2.Indian Council of Med. Res.Cambr. Printing Works,New Delhi.600pp Note: (2 vols so far).

PC29(5):1667: Jung, J.H., Pummangura, S., Chaichantipyuth, c., Patarapanich, C., and McLaughlin, J.L. 1989. Bioactive Constituents of Melodorum fruticosum. Phytochemistry. 29(5): 1667-1670. 1990.

PC44:1037: Jim Duke's personal files

PJB1(2):287: Jim Duke's personal files

PMP23:60: Jim Duke's personal files

PMP25:56: Jim Duke's personal files

PS131:95: Madhavi, D. L., Bomser, J., Smith, M., Singletary, K. 1998. Isolation of Bioactive Constituents from Vaccinium myrtillus (Bilberry) Fruits and Cell Cultures. Plant Sci., 131(1): 95-103.

PS75:161: Abid Ali Khan, M.M., Jain, D.C., Bhakuni, R.S., Zaim, M., and Thakur, R.S. 1991. Occurrence of some antiviral sterols in Artemisia annua. Plant Science, 75: 161-165, 1991.

QJC28:155: Recently became Internat. J. Crude Drug Res. 28(1,2,3,4):1990, page 155.

WOI: ANON. 1948-1976. The Wealth of India raw materials. Publications and Information Directorate, CSIR, New Delhi. 11 volumes.

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