Dr. Duke's
Phytochemical and Ethnobotanical Databases

Chemicals and their Biological Activities in: Schinus terebinthifolius RADDI (Anacardiaceae) -- Brazilian Peppertree

Chemicals

3-ALPHA-HYDROXYMASTICODIENONIC-ACID Leaf: DUKE1992A

No activity reported.

BAURENONE Plant: DUKE1992A

No activity reported.

CARDOL Resin, Exudate, Sap: DUKE1992A

Antifilarial IJP52:271 ; Cyclooxygenase-Inhibitor IC28-98=10 uM DFN:162 ; Molluscicide ED=7-15 ppm DUKE1992B ; Pesticide DUKE1992B

KAEMPFEROL Leaf: DUKE1992A

11B-HSD-Inhibitor CPT59:62 ; 5-Lipoxygenase-Inhibitor IC50 (uM)=20; Aldose-Reductase-Inhibitor 100 uM JBC8:211 ; Antiaggregant 30 uM; Antiallergic RWG122 ; Antibacterial 20 ug/ml; Anticancer JAF47:397 ; Antifertility 250 mg/kg day/60 days/orl rat PMP23:193 ; Antigingivitic 20 ug/ml JNP59:987 ; Antihistaminic 411 ; Antiimplantation JE32:175 ; Antiinflammatory 20 mg/kg DUKE1992B 200 mg/kg ipr rat DUKE1992B ; Antileukemic IC50=3.1 ug/ml LS55:1061 ; Antilymphocytic JBH ; Antimutagenic ID50=10-40 nM PCF ; Antioxidant IC50=40 uM PC27:972 ; Antiperiodontic 20 ug/ml JNP59:987 ; Antiplaque JNP59:987 ; Antiradicular 7 x quercetin; Antiseptic 20 ug/ml JNP59:987 ; Antiserotonin 200 mg/kg ipr rat FT63(1):3 ; Antispasmodic 411 ; Antitumor JAF47:397 ; Antitumor-Promoter CPB38:774 ; Antiulcer 50-200 mg/kg ipr rat; Antiviral; Apoptotic 60 uM PMID10673981 ; Aromatase-Inhibitor IC12=1 uM/l JMF2:235 ; cAMP-Phosphodiesterase-Inhibitor AFR27:180 ; Cancer-Preventive 525 ; Carcinogenic ZUL ; Choleretic LAF ; COX-2-Inhibitor COX:50 ; Cyclooxygenase-Inhibitor IC50 (uM) =20; Diaphoretic? LRN-DEC90 ; Diuretic BJP3:10 ; Estrogenic EC50=0.1-25 uM/l JMF2:227 EC50=0.56 uM PMID10923837 ; HIV-RT-Inhibitor IC50=50-150 ug/ml JNP54:142 ; Hypotensive FT1990:508 ; Inotropic PMID10404425 ; Iodothyronine-Deiodinase-Inhibitor JBH ; Lipoxygenase-Inhibitor JBH ; MAO-Inhibitor PMID10813558 ; Mutagenic JBH ; Natriuretic BJP3:10 ; Neuroprotective PMID10813558 ; PAF-Inhibitor FT67:548 ; Pesticide DUKE1992B ; Protisticide PR13:102 ; Quinone-Reductase-Inducer 3 uM; Teratologic DUKE1992B ; Topoisomerase-I-Inhibitor TIH14:223 ; Topoisomerase-II-Inhibitor IC50=8.1 ug/ml JNP58:217 ; Uterotrophic EC50=0.1-25 uM/l JMF2:227 ; Vasodilator JAFC48:220

LEUCOCYANIDIN Plant: DUKE1992A

Capillariprotective M11

MASTICODIENONIC-ACID Leaf: DUKE1992A

No activity reported.

MYRICETIN Leaf: DUKE1992A

Allelochemic IC82=1 mM 438 ; Antiallergenic RWG122 ; Antibacterial MIC=20-500 ug/ml; Antifeedant IC52=<1,000 ppm diet 438 ; Antigastric DUKE1992B ; Antigingivitic MIC=20 ug/ml JNP59:987 ; Antigonadotrophic JBH ; Antihistaminic RWG122 ; AntiHIV POP:270 ; Antiinflammatory OMM ; Antimutagenic ID50=2-5 nM PCF ; Antioxidant 1.4 uM P&T78:143 IC99=200 ppm PCF ; Antiperiodontic MIC=20 ug/ml JNP59:987 ; Antiplaque JNP59:987 ; Antiseptic JNP59:987 ; Antiviral POP:270 ; Apoptotic 60 uM PMID10673981 ; Cancer-Preventive 525 ; Candidicide MIC=150 ug/ml PM57:A43 ; COMP-Inhibitor JCN70:1040 ; Diuretic OMM ; Hypoglycemic EMP6:170 ; Larvistat IC50=2.6-3.5 mM/kg diet 438 ; Lipoxygenase-Inhibitor JBH ; Mutagenic NIG ; Oxidase-Inhibitor JBH ; Pesticide DUKE1992B ; Quinone-Reductase-Inducer 36 uM CLE120:213 ; Topoisomerase-I-Inhibitor IC50=11.9 ug/ml; Topoisomerase-II-Inhibitor; Tyrosine-Kinase-Inhibitor EMP6:170 ; Vasodilator JAFC48:220

PHELLANDRENE Seed: DUKE1992A

Hyperthermic HG22:45 ; Irritant RIN ; Spasmogenic FT59:465 ; Tumor-Promoter AEHD1:131

QUERCETIN Plant: DUKE1992A

11B-HSD-Inhibitor CPT59:62 ; 5-Lipoxygenase-Inhibitor IC50 (uM)=4; Aldose-Reductase-Inhibitor 100 uM 4 ug/ml SKN43:99 IC50=0.344 uM ZZZ18:623 IC50=0.84 ug/ml cow CPB43:1385 ; Allelochemic IC82=1 mM 438 ; Allergenic JBH ; Analgesic FT63(3):197 ; Antiaggregant 30 uM JAF45:4505 IC50=55 uM EMP5:333 ; Antiallergic IC50=14 uM JIM127:546 ; Antianaphylactic PR4(5):201 ; Antiasthmatic; Antiatherosclerotic PMID11020457 ; Antibacterial JBH ; Anticarcinomic (Breast) IC50=1.5 uM MED ; Anticariogenic ID50=120 ug/ml JAF48:5666 ; Anticataract PM56(3):258 ; Anticolitic 400 mg/man/3x/day PAM ; AntiCrohn's PAM ; Antidermatitic PAM ; Antidiabetic; Antielastase IC50=0.8 ug/ml DUKE1992B ; Antiencephalitic EMP5:199 ; Antiescherichic PMID10857921 ; Antiestrogenic; Antifeedant IC52=<1,000 ppm diet 438 ; Antifibrosarcomic JAF45:4505 ; Antiflu V&D ; Antigastric RR21:85 ; Antigonadotropic JBH ; AntiGTF ID50=120 ug/ml JAF48:5666 ; Antihepatotoxic PM56(2):171 ; Antiherpetic PAM ; Antihistaminic IC50=<10 uM; AntiHIV JNP60(9):884 ; Antihydrophobic V&D ; Antihypertensive KCH ; Antiinflammatory (20 mg/kg) 150 mg/kg FT5:1990 ; Antileukemic 5.5-60 uM BO2 IC50=10 uM EMP5:225 IC50=>10 ug/ml LS55:1061 ; Antileukotriene PAM ; Antilipoperoxidant IC67=50; Antimalarial IC50=1-6.4 ug/ml MPT ; Antimelanomic; Antimutagenic ID50=2-5 nM PCF ; Antimyocarditic EMP5:199 ; Antinitrosaminic PAL:339 ; Antioxidant 4.7 x Vit. E BO2 ED50=2.3 uM PR14:93 IC96=300 ppm PCF ; Antipancreatitic JNU ; Antiperiodontal PAM ; Antipermeability DUKE1992B ; Antiperoxidant PM57:A110 ; Antipharyngitic PAM ; Antiplaque PAM ; AntiPMS 500 mg/2x/day/wmn PAM ; Antipodriac PAM ; Antipolio PAM ; Antiproliferant JNM7:51 ; Antiprostanoid PCF:51 ; Antiprostatitic JNU ; Antipsoriac PAM ; Antiradicular IC50=4.6 uM PM56(6):695 ; Antispasmodic; Antistreptococcic ID50=120 ug/ml JAF48:5666 ; Antithiamin PCF:69 ; Antithrombic PAL:339 ; Antitumor 10 uM; Antitumor (Bladder) JNM7:51 ; Antitumor (Breast) JNM7:51 ; Antitumor (Colon) JAF45:4505 ; Antitumor (Lung) PMID10918203 ; Antitumor (Ovary) JNM7:51 ; Antitumor (Skin) 20 uM BO2 ; Antitumor-Promoter PAM ; Antiviral IC50=10 uM; Apoptotic 20-60 uM; ATPase-Inhibitor NIG ; Bacteristat 10 mg/ml QRNM(SUMMER):91 ; Bradycardiac KCH ; Calmodulin-Antagonist PAM ; cAMP-Phosphodiesterase-Inhibitor PAM ; Cancer-Preventive 525 ; Candidicide PMID10857921 ; Capillariprotective M11 ; Carcinogenic 40,000 ppm (diet) mus NIG ; Catabolic AFR27:173 ; COMT-Inhibitor QRNM1997:293 ; Copper-Chelator PR14:93 ; COX-2-Inhibitor <40 uM BO2 ; Cyclooxygenase-Inhibitor PCF:49 ; Cytotoxic ED50=70 ug/ml PM56(6):677 IC82=100 ug/ml PM57:A113 ; Deiodinase-Inhibitor JNM1:10 ; Diaphoretic? LRN-DEC90 ; Differentiator 5.5 uM BO2 ; Estrogenic 10% genistein B02 ; Fungicide PMID10857921 ; Glucosyl-Transferase-Inhibitor ID50=120 ug/ml JAF48:5666 ; Hemostat KCH ; Hepatomagenic 5,000 ppm (diet) rat PCF ; Hepatoprotective FT67:200 ; HIV-RT-Inhibitor IC50=<1 ug/ml JNP53(5):1239 ; Hypoglycemic 100 mg/kg orl rat JE27:243 ; Inotropic PMID10404425 ; Insulinogenic PAM ; Juvabional 438 ; Larvistat 8,000 ppm diet 438 ; Lipoxygenase-Inhibitor IC11=1.25 mM JAF38:688 IC50=0.1-5 uM DFN:154 ; MAO-A-Inhibitor QRNM1997:293 ; Mast-Cell-Stabilizer DUKE1992B ; Metal-Chelator (Copper) PR14:93 ; MMP-9-Inhibitor 20 uM BO2 ; Mutagenic HG22:27 ; NADH-Oxidase-Inhibitor BJP3:10 ; Neuroprotective 5-25 uM PMID11030720 ; Ornithine-Decarboxylase-Inhibitor <10 uM; P450-Inducer 5 uM FNF ; P450-Inhibitor 50-100 uM FNF ; Pesticide DUKE1992B ; Phospholipase-Inhibitor BJP3:10 ; Prostaglandin-Synthesis-Inhibitor 40 ug/ml PR11:281 ; Protein-Kinase-C-Inhibitor PCF:14 ; PTK-Inhibitor 0.4-24 uM BO2 ; Quinone-Reductase-Inducer 13 uM 6 uM CLE120:213 ; Teratologic DUKE1992B ; Topoisomerase-I-Inhibitor IC50=12.8 ug/ml IC50=42 uM BO2 ; Topoisomerase-II-Inhibitor IC50=1-6.9 ug/ml IC50=23-40 uM BO2 ; Tumorigenic 0.1% diet orl rat/yr 505 ; Tyrosine-Kinase-Inhibitor EMP6:170 ; Vasodilator; Xanthine-Oxidase-Inhibitor IC50=>0.4 ug/ml CPB38:1772

SCHINOL Fruit: DUKE1992A

No activity reported.

TEREBINTHIFOLIC-ACID Plant: DUKE1992A

No activity reported.

TEREBINTHONE Fruit: DUKE1992A

No activity reported.

TRIACONTANE Leaf: DUKE1992A

No activity reported.

References

411: Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.

438: Lydon, J. & Duke, S., The potential of pesticides from plants, pp. 1-41 in Craker, L. & Simon, J., eds, Herbs, Spices & Medicinal Plants: Recent Advances in Botany, Horticulture, & Pharmacology, v. 4, Oryx Press, Phoenix, 1989, 267pp.

505: Jim Duke's personal files.

525: Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

AEHD1:131: Jim Duke's personal files

AFR27:173: Jim Duke's personal files

AFR27:180: Jim Duke's personal files

B02: Jim Duke's personal files

BJP3:10: Jim Duke's personal files

BO2: Jim Duke's personal files

CLE120:213: Uda, Y., Price, K. R., Williamson, G., Rhodes, M. J. C. 1997. Induction of the Anticarcinogenic Marker Enzyme, Quinone Reductase, in Murine Hepatoma Cells In Vitro by Flavonoids. Cancer Lett., 120 (2): 213-216.

COX:50: Jim Duke's personal files

CPB38:1772: Chem. & Pharm. Bull. 38: 1772.

CPB38:774: Yasukawa, K., Takido, M., Takeuchi, M., Sato, Y., Nitta, K., and Nakagawa, S. 1989. Inhibitory Effects of Flavonol Glycosides on 12-O-Tetradecanoylphorbol-13-acetate-Induced Tumor Promotion. Chem. Pharm. Bull. 38(3): 774-776, 1990.

CPB43:1385: Okada,Y,et al.1995.Search for Naturally Occurring Substances to Prevent the Complications of Diabetes.II.Inhibitory Effect of Coumarin and Flavonoid Derivatives on Bovine Lens Aldose Reductase and Rabbit Platelet Aggregation.Chem Pharm Bull43(8):1385-1387

CPT59:62: Jim Duke's personal files

DFN:154: Jim Duke's personal files

DFN:162: Jim Duke's personal files

DUKE1992A: Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.

EMP5:199: Economic & Medicinal Plant Research, 5: 199.

EMP5:225: Economic & Medicinal Plant Research, 5: 225.

EMP5:333: Economic & Medicinal Plant Research, 5: 333.

EMP6:170: Economic & Medicinal Plant Research, 6: 170.

FNF: Father Nature's Farmacy: The aggregate of all these three-letter citations.

FT1990:508: Jim Duke's personal files

FT59:465: Fitoterapia No.59-1984.

FT5:1990: Fitoterapia No.5-1990.

FT63(1):3: Jim Duke's personal files

FT63(3):197: Jim Duke's personal files

FT67:200: Jim Duke's personal files

FT67:548: Jim Duke's personal files

HG22:27: Jim Duke's personal files

HG22:45: HerbalGram No. 22 - Spring 1990, page 45.

IJP52:271: Jim Duke's personal files

JAF38:688: Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690.

JAF45:4505: Jim Duke's personal files

JAF47:397: Jim Duke's personal files

JAF48:5666: Jim Duke's personal files

JAFC48:220: Jim Duke's personal files

JBC8:211: Oliveira, T. T., Nagem, T. J., Miranda, L. C. G., Paula, V. F., Teixeira, M. A. 1997. Inhibitory Action on Aldose Reductase by Soybean Flavonoids. J Braz Chem Soc, 8(3): 211-213.

JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

JCN70:1040: Dullo, A. G., et al. 1999. Efficacy of a green tea extract rich in catechin polyphenols and caffeine in increasing 24-h energy expenditure and fat oxidation in humans. Am. J. Clinical Nutrition, 70: 1040-1045.

JE27:243: Ivorra, M.D., Paya, M., and Villar, A. 1989. A Review of Natural Products and Plants as Potential Antidiabetic Drugs. Journal of Ethnopharmacology, 27: 243-275, 1989.

JE32:175: Jim Duke's personal files

JIM127:546: Jim Duke's personal files.

JMF2:227: Journal of Medicinal Food 2: 227.1999.

JMF2:235: Journal of Medicinal Food 2: 235.1999.

JNM1:10: Jim Duke's personal files.

JNM7:51: Jim Duke's personal files

JNP53(5):1239: Nakane, H., Fukushima, M., and Ono*, K. Differential Inhibition Of Reverse Transcriptase And Various DNA Polymerases By Digallic Acid And Its Derivatives. Journal of Natural Products, 53(5): 1234-1240, 1990.

JNP54:142: Garcia, J., Morin,* C., Nyasse, B., Sondengam, B-L., Tchouankeu, J-C., and Tsamo, E. Complete Structural Assignments Of An Ergosterol Derivative From Entandrophragma utile. Journal of Natural Products, 54(1): 136-142, 1991.

JNP58:217: Constantinou, A., Mehta, R., Runyan, C., Rao, K., Vaughan, A., Moon, R. 1995. Flavonoids as DNA Topoisomerase Antagonists and Poisons: Structure-Activity Relationships. J Natural Products, 58: 217-225.

JNP59:987: Jim Duke's personal files

JNP60(9):884: Jim Duke's personal files

JNU: Jim Duke's personal files

KCH: Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.

LAF: Leung, A. Y. and Foster, S. 1995. Encyclopedia of Common Natural Ingredients 2nd Ed. John Wiley & Sons, New York. 649 pp.

LRN-DEC90: Lawrence Review of Natural Products, Dec-90.

LS55:1061: Life Sciences 55: 1061.

M11: Merck 11th Edition

MED: Medline (post 1990 searches filed in my computer)

MPT: Medicinal and Poisonous Plants of the Tropics. Leeuwenberg, A.J.M., ed. Pudoc, Wageningen. 1987.

NIG: Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.

OMM: Oriental Materia Medica (three volumes by Dr. Hsu and collaborators)

P&T78:143: Jim Duke's personal files

PAL:339: Jim Duke's personal files

PAM: Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).

PC27:972: Jim Duke's personal files

PCF: Phenolic Compounds in Food and Their Effects on Health. Antioxidants & Cancer Prevention. Huang, M.T., Ho, C.T. and Lee, C.Y. eds. 1992. ACS Symposium Series 507.ACS, Washington 402 pp.

PCF:14: Naim, M., Zehavi, U., Nagy, S., and Rouseff, R.L. Hydroxycinnamic Acids as Off-Flavor Precursors in Citrus Fruits and Their Products. Phenolic Compounds in Food and Their Effects on Health, Ch.14.

PCF:49: Jim Duke's personal files

PCF:51: Jim Duke's personal files

PCF:69: Phenolic Compounds in Food and Their Effects on Health, 69.

PM56(2):171: Joyeux, M., Rolland, A., Fleurentin, J., Mortier, F., and Dorfman, P. 1989. Tert-Butyl Hydroperoxide-Induced Injury in Isolated Rat Hepatocytes: A Model for Studying Anti-Hepatotoxic Crude Drugs. Planta Medica 56(2): 171-173, 1990.

PM56(3):258: Jim Duke's personal files

PM56(6):677: Matsukawa, Y., et al. The Effect of Quercetin and Other Flavonoids on Cell Cycle Progresssion and Growth of Human Gastric Cancer Cells. Planta Medica, 56(6): 677, 1990.

PM56(6):695: Planta Medica, 56(6): 695, 1990.

PM57:A110: Planta Medica, 57: A110, 1991.

PM57:A113: Planta Medica, 57: A113, 1991.

PM57:A43: Planta Medica, 57: A43, 1991.

PMID10404425: Jim Duke's personal files

PMID10673981: Jim Duke's personal files

PMID10813558: Jim Duke's personal files

PMID10857921: Jim Duke's personal files

PMID10918203: Jim Duke's personal files

PMID10923837: Jim Duke's personal files

PMID11020457: Jim Duke's personal files

PMID11030720: Jim Duke's personal files

PMP23:193: Kumar, P., Dixit*, V.P., and Khanna, P. Antifertility Studies of Kaempferol: Isolation and Identification from Tissue Culture of some Medicinally Important Plant Species. Plantes medicinales et phytotherapie, 23: 193-201, 1989.

POP:270: Jim Duke's personal files

PR11:281: Ibewuike, J. C., Ogungbamila, F. O., Ogundaini, A. O., Okeke, I. N., Bohlin, L. 1997. Antiinflammatory and Antibacterial Activities of C-methylflavonol from Piliostigma thonningii. Phytotherapy Research, 11(4): 281-284.

PR13:102: Meckes, M., Calzada, F., Tapia-Contreras, A., Cedillo-Rivera, R. 1999. Antiprotozoal Properties of Helianthemum glomeratum. Phytotherapy Research, 13(2): 102-105.

PR14:93: Seidel, V., Verholle, M., Malard, Y., Tillequin, F., Fruchart, J-C., Duriez, P., Bailleul, F., Teissier, E. 2000. Phenylpropanoids from Ballota nigra L. Inhibit in vitro LDL Peroxidation. Phytotherapy Research, 14(2): 93-98.

PR4(5):201: Meli, R., Autore, G., Di Carlo, G., Capasso, F. Inhibitory Action of Quercetin on Intestinal Transit in Mice. Phytotherapy Research 4(5): 201, 1990.

QRNM(SUMMER):91: Jim Duke's personal files

QRNM1997:293: Jim Duke's personal files

RIN: Rinzler, C. A. 1990. The Complete Book of Herbs, Spices and Condiments. Facts on File, New York. 199 pp.

RR21:85: Rastitel'nye Resursy, 21: 85.

RWG122: Jim Duke's personal files

SKN43:99: Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.

TIH14:223: Santti, R., Makela, S., Strauss, L., Korman, J., Kostian, M. L. 1998. Phytoestrogens: Potential Endocrine Disruptors in Males. Toxicol Ind Health, 14: 223-237.

V&D: Vlietinck, A.J. and Dommisse, R.A. eds. 1985. Advances in Medicinal Plant Research. Wiss. Verlag. Stuttgart.

ZUL: Hutchings, A, Scott, AH, Lewis, G, and Cunningham, A. 1996. Zulu Medicinal Plants. An inventory. University of Natal Press, Pietermaritzburg. 450 pp.

ZZZ18:623: Mao, X. M., Zhang, J. Q. 1993. Inhibition of Aldose Reductase by Extracts of Chinese Herbal Medicine. Zhongguo Zhongyao Zazhi , 18(10): 623-624.

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