Agricultural Research Service - ARS

Dr. Duke's
Phytochemical and Ethnobotanical Databases

Chemicals and their Biological Activities in: Ziziphus joazeiro (Rhamnaceae)


Chemicals

BETULINIC-ACID Bark: JAD Stem Bark 1,200 ppm; JAD
Anticarcinomic JBH ; AntiHIV EC50=2.0 ug/ml JNP61:1090 IC50=6.5 ug/ml JNP57:243 ; Antiinflammatory PM61:9 ; Antimalarial IC50=19-26 ug/ml PR13:115 ; Antimelanomic NYT3/28/95 ; Antiplasmodial PR13:115 ; Antitumor JBH ; Antiviral JNP57:243 ; Cytotoxic 50-100 ppm BPCC ; Prostaglandin-Synthesis-Inhibitor 200 ug/ml PC48:495 IC50=101 uM YHH30:621

References

BPCC: Biosyn. Prod. Cancer Chemotherapy (Petit et al)
JAD: Duke, J. A. Writeups or information summaries on approximately 2,000 economic plants, USDA, ARS, Beltsville, MD 20705.
JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.
JNP57:243: Fujioka, T., Kashiwada, Y., et al. Anti-AIDS Agents 11. Betulinic Acid and Platanic Acid as Anti-HIV Principles From Syzigium claviflorum, and the Anti-HIV Activity of Structurally Related Triterpenoids. Journal of Natural Products, 57(2): 243-247, 1994.
JNP61:1090: Kashiwada, Y., et. al. 1998. Anti-AIDS Agents. 30. Anti-HIV Activity of Oleanolic Acid, Pomolic Acid, and Structurally Related Triterpenoids. J. Nat. Prod., 61 (9): 1090-1095.
NYT3/28/95: New York Times, 3/28/95.
PC48:495: Dunstan, C. A., Liu, B., Welch, C. J., Perera, P., Bohlin, L. 1998. Alphitol, a Phenolic Substance from Alphitonia zizyphoides which Inhibits Prostaglandin Biosynthesis in vitro. Phytochemistry, 48(3): 495-497.
PM61:9: Recio, M., et al. 1994. Investigations on the Steroidal Anti-Inflammatory Activity of Triterpenoids from Diospyros leucomelas*. Planta Medica, 61: 9.
PR13:115: Jim Duke's personal files
YHH30:621: Huang, C., Tunon, H., Bohlin, L. 1995. Anti-Inflammatory Compounds Isolated from Menyanthes trifoliata L. Yao Hsueh Hsueh Pao, 30(8): 621-626.

Ubiquitous chemicals not included in analysis
ppm = parts per million
tr = trace

Phytochemical Database, USDA - ARS - NGRL, Beltsville Agricultural Research Center, Beltsville, Maryland
Thu May 16 16:18:53 EDT 2002

Please send questions and comments to:

James A. Duke (E-Mail: JimDuke@cpcug.org)
or
Stephen M. Beckstrom-Sternberg (E-Mail: SteveBS@nhgri.nih.gov)

Please send technical questions and comments to:

WebMaster (E-Mail: WebMaster@ars-grin.gov)

The USDA does not recommend self diagnosis or self medication. Please see the disclaimer for more information.