Dr. Duke's
Phytochemical and Ethnobotanical Databases

Chemicals and their Biological Activities in: Annona muricata L. (Annonaceae) -- Soursop

Chemicals

AMYL-CAPROATE Plant: DUKE1992A

FLavor FEMA 50-100 ARC

AMYLOID Plant: DUKE1992A

No activity reported.

ANNONAIN Plant: DUKE1992A

No activity reported.

ANOMURICINE Plant: DUKE1992A

No activity reported.

ANOMURICININE Plant: DUKE1992A

No activity reported.

ANOMURINE Plant: DUKE1992A

No activity reported.

ANONOL Plant: DUKE1992A

No activity reported.

ATHEROSPERMININE Plant: DUKE1992A

No activity reported.

CAFFEIC-ACID Plant: DUKE1992A

Aldose-Reductase-Inhibitor 4 ug/ml (weak activity) SKN43:99 ; Allergenic M&R317 ; Analgesic PMP23:51 ; Antiadenoviral EMP5:207 ; Antiaggregant JBH ; Antibacterial PAM ; Anticancer JAF47:397 ; Anticarcinogenic EMP6:189 ; Antiedemic EMP6:189 ; Antielastase IC50=93 um/l PMID11199135 ; Antiflu EMP5:207 ; Antigonadotropic JNM1:10 ; Antihemolytic 25 uM PC36:579 ; Antihepatoadenomic 200 ppm diet orl mus ACS661:230 ; Antihepatotoxic PM56:173 ; Antiherpetic 50 ug/ml EC50=>50 ug/ml POP:270 ; Antihistaminic DUKE1992B ; AntiHIV EC50=200 ug/ml; Antihypercholesterolemic EMP6:189 ; Antiinflammatory JBH ; Antileukotriene DUKE1992B ; Antimutagenic PCF:18 ; Antinitrosaminic PCF:18 ; Antiophidic FT65(2):101 ; Antioxidant 1.3 x Vit. E BO2 1/3 quercetin JAF47:397 30 mM JAF48:235 50 um PC27:973 IC57=30 ppm PCF:221 ; Antiperoxidant IC50=44 uM PM57:A54 ; Antiprostaglandin PJB1(1):169 ; Antiradicular 1/3 quercetin JAF47:397 10 uM PC36:579 30 mM JAF48:235 ; Antiseptic JE26:76 ; Antispasmodic EC50=3.4-15 uM PR4:73 ; Antistomatitic EMP5:207 ; Antisunburn PM61:510 ; Antithiamin PCF:69 ; Antithyroid JNM1:10 ; Antitumor 200 ppm diet orl mus; Antitumor-Promoter IC42=10 uM CR48:5941 ; Antiulcerogenic; Antivaccinia EMP5:207 ; Antiviral IC50=62.5 ug/ml; Calcium-Antagonist IC50=1.2 uM rbt K16299 ; Cancer-Preventive 525 ; Carcinogenic 2% (diet) PCF:39,277 ; Cholagogue WIC ; Choleretic 411 ; Clastogenic JBH ; CNS-Active WIC ; Co-carcinogenic PCF:44 ; Collagen-Sparing PM61:510 ; Cytoprotective CAN ; Cytotoxic TC50=200 ug/ml POP:270 ; Diuretic WIC ; DNA-Active JBH ; Fungicide MIC=0.4 mg/ml; Hepatocarcinogenic 400 ppm diet orl mus (in the absence of alcohol) ACS661:230 ; Hepatoprotective ACM:210 ; Hepatotropic DUKE1992B ; Immunostimulant PPL7:187 ; Insectifuge EB48:111 ; Lipoxygenase-Inhibitor IC27=5 mM JAF38:688 IC50=62-148 uM JAF44:2057 ; Lyase-Inhibitor IC50=94-164 uM JAF44:2057 ; Metal-Chelator PCF:25 ; Ornithine-Decarboxylase-Inhibitor PCF:19 ; Pesticide DUKE1992B ; Prooxidant JAFC45:632 ; Prostaglandigenic RWG27 ; Sedative 500 mg RWG17 ; Sunscreen IC50=2.5 mg/l FT64:134 IC91=5 mg/l FT64:134 IC98=25 mg/l FT64:134 ; Tumorigenic 505 ; Vulnerary JE26:76 ; Xanthine-Oxidase-Inhibitor IC50=39.21 um MAB

CAMPESTEROL Plant: DUKE1992A

No activity reported.

CELLOBIOSE Plant: DUKE1992A

No activity reported.

CITRULLINE Plant: DUKE1992A

Antiasthenic 180 mg/kg/day M29 6 g/day/orl/man M29 ; Antihepatotic M11 ; Antiosteoporotic? M29 ; Diuretic DUKE1992B

COCLAURINE Plant: DUKE1992A

Antiaggregant CPJ46:438 ; Antioxidant IC50=>100ug/ml DUKE1992B ; Antiradicular PM56(6):645 ; Cytotoxic CPJ46:438 ; Depressant DUKE1992B ; Hypothermic 200-500 mg/kg 526

COREXIMINE Plant: DUKE1992A

Antihypertensive GMJ ; Respirastimulant GMJ

DEXTROSE Plant: DUKE1992A

Sweetener 0.74 x sucrose MAR

GABA Plant: DUKE1992A

Analeptic DUKE1992B ; Anticephalagic DUKE1992B ; Anticerebrotic JBH ; Antichoreic 1-32 g/man/day M29 ; Anticonvulsant 4,120 mg/kg ipr mus BBE ; Antihypertensive 1,000-4,000 mg/man/day DUKE1992B ; Antiinsomniac DUKE1992B ; Antilethargic DUKE1992B ; Antistress SHT76 ; Antitinnitic DUKE1992B ; Anxiolytic SHT76 ; Cardiovascular 208 ivn dog BBE ; CNS-Inhibitor 0.1 mg/kg ivn cat BBE 100 mg/kg ivn dog BBE 2,500 mg/kg scu mus BBE ; Diuretic 1,500-4,000 mg/man/day IJO13:168 ; Hypotensive 1,000-4,000 mg/day DUKE1992B ; Neuroinhibitor OHAI13:165 ; Neurotoxic (to birds) JBH ; Neurotransmitter; Sedative HG40:12 ; Tranquilizer WER

GALACTOMANNAN Plant: DUKE1992A

No activity reported.

GERANYL-CAPROATE Plant: DUKE1992A

FLavor FEMA 1-3 ARC ; Perfumery ARC

HCN Plant: DUKE1992A

Antiasthmatic KCH ; Antidote Ihl (=Amyl Nitrite) M29 ; Antitussive KCH ; Bronchosedative KCH ; Insecticide 382 ; Pesticide DUKE1992B ; Respirastimulant KCH ; Rodenticide M29 ; Vasomotor-Stimulant DUKE1992B

ISOCITRIC-ACID Plant: DUKE1992A

No activity reported.

MALIC-ACID Plant: DUKE1992A

Bacteristat DUKE1992B ; Bruchiphobe 382 ; Hemopoietic DUKE1992B ; Laxative? LRN-SEP91 ; Pesticide DUKE1992B ; Sialogogue M29

MERICYL-ALCOHOL Plant: DUKE1992A

No activity reported.

METHANOL Plant: DUKE1992A

Antidote =Sodium-bicarbonate M29 ; AntiHIV EC50=<20 ug/ml DUKE1992B

METHYL-HEX-2-ENOATE Plant: DUKE1992A

No activity reported.

METHYL-HEXANOATE Plant: DUKE1992A

No activity reported.

MURICINE Plant: DUKE1992A

No activity reported.

MURICININE Plant: DUKE1992A

No activity reported.

P-COUMARIC-ACID Plant: DUKE1992A

Aldose-Reductase-Inhibitor 4 ug/ml (weak activity) SKN43:99 ; Allelopathic JBH ; Antibacterial PHZ46:156 ; Antifertility AEHD1:84 ; Antihepatotoxic JBH ; Antinitrosaminic JNU ; Antioxidant IC24=30 ppm; Antiperoxidant IC50=>100 uM PM57:A54 ; Antispasmodic CAN ; Antitumor; Cancer-Preventive 525 ; Choleretic DUKE1992B ; Cytotoxic JBH ; Diaphoretic? LRN-DEC90 ; Fungicide NIG ; Lipoxygenase-Inhibitor IC11=5 mM JAF38:688 ; Pesticide DUKE1992B ; Prostaglandigenic RWG27 ; Prostaglandin-Synthesis-Inhibitor DUKE1992B

PARAFFIN Plant: DUKE1992A

Antihemorrhoidal M29 ; Antiproctalgic M29 ; Emollient M29 ; Laxative 45 mL/day/orl/man/ M29

POTASSIUM-CHLORIDE Plant: DUKE1992A

No activity reported.

PROCYANIDIN Plant: DUKE1992A

Antiallergic IJO16:204 ; Antibacterial PM56(6):577 ; Antibiotic DUKE1992B ; Antiedemic APP16:50 ; Antiexudative APP16:50 ; AntiHIV DUKE1992B ; Antiviral DUKE1992B ; Capillariprotective APP16:50 ; Hyaluronidase-Inhibitor IJO16:204 ; Pesticide DUKE1992B ; Xanthine-Oxidase-Inhibitor IC50=>40 CPB38:1225

RETICULINE Plant: DUKE1992A

Analgesic GMJ ; Antibacterial GMJ ; Antidopaminergic GMJ ; Antispasmodic GMJ ; CNS-Stimulant GMJ ; Convulsant GMJ ; Fungicide JE36:39 ; Hyperthermic GMJ ; Pesticide DUKE1992B ; Pyrogenic 5-20 mg/kg ipr rat JNP42:399

SCYLLITOL Plant: DUKE1992A

No activity reported.

STEPHARINE Plant: DUKE1992A

No activity reported.

UFA Seed 159,000 ppm; DUKE1992A

No activity reported.

VIT-B-6 Fruit 0.6 - 3 ppm DUKE1992A

No activity reported.

XYLOSYL-CELLULOSE Plant: DUKE1992A

No activity reported.

References

382: Jacobson, M., Glossary of Plant-Derived Insect Deterrents, CRC Press, Inc., Boca Raton, FL, 213 p, 1990.

411: Williamson, E. M. and Evans, F. J., Potter's New Cyclopaedia of Botanical Drugs and Preparations, Revised Ed., Saffron Walden, the C. W. Daniel Co., Ltd., Essex UK, 362 pp, 1988, reprint 1989.

505: Jim Duke's personal files.

525: Stitt, P. A. Why George Should Eat Broccoli. Dougherty Co, Milwaukee, WI, 1990, 399 pp.

526: Collins, D.J., Culvenor, C.C.J., Lamberton, J.A., Loder, J.W. and Price, J.R., Plants for Medicines, CSIRO, East Melbourne, Australia, 1990, 303 pp.

ACM:210: Advance in Chinese Medicinal Materials Research. 1985. Eds. H. M. Chang, H. W. Yeung, W. -W. Tso and A. Koo. World Scientific Publishing Co., Philadelphia Pa., page 210.

ACS661:230: Jim Duke's personal files

AEHD1:84: Jim Duke's personal files

APP16:50: Jim Duke's personal files

ARC: Aloe Research Council - Duke writeup of non-peer reviewd book by Coats and draft by Henry Note: Most ARC numerical data were in mg/dl. I know of no other plant where zinc is more prevalent than other minerals and protein. These data should be viewed as suspect.

BBE: Borchard, R. E., Barnes, C. D., and Eltherton, L. G. 1991. Drug Dosage in Laboratory Animals: A Handbook. (3rd Ed.) The Telford Press, Inc., P. O. Box 287, Caldwell NJ 07006.

BO2: Jim Duke's personal files

CAN: Newall, C. A., Anderson, L. A. and Phillipson, J. D. 1996. Herbal Medicine - A Guide for Health-care Professionals. The Pharmaceutical Press, London. 296pp.

CPB38:1225: Hatano, T., Yasuhara, T., Yoshihara, R., Agata, I., Noro, T., and Okuda, T. 1989. Effects of Interaction of Tannins with Co-existing Substances.VII. Inhibitory Effects of Tannins Related Polyphenols on Xanthine Oxidase. Chem. Pharm. Bull. 38(5): 1224-1229

CPJ46:438: Jim Duke's personal files

CR48:5941: Cancer Research, 48: 5941.

DUKE1992A: Duke, James A. 1992. Handbook of phytochemical constituents of GRAS herbs and other economic plants. Boca Raton, FL. CRC Press.

DUKE1992B: Duke, James A. 1992. Handbook of biologically active phytochemicals and their activities. Boca Raton, FL. CRC Press.

EB48:111: Tunon, H., Thorsell, W., and Bohlin, L. 1993. Mosquito Repelling Activity of Compounds Occurring in Achillea millefolium L. (Asteraceae). Economic Botany 48(2): 111-120, 1994.

EMP5:207: Economic & Medicinal Plant Research, 5: 207.

EMP6:189: Economic & Medicinal Plant Research, 6: 189.

FT64:134: Lazarova*, G., Kostova, I., Neychev, H. 1992. Photodynamic damage prevention by some hydroxycoumarins. Fitoterapia 64(2): 134-136, 1993.

FT65(2):101: Jim Duke's personal files

GMJ: Grenand, P., Moretti, C., and Jacquemin, H. 1987. Pharmacopees Traditionnelles en Guyane. l'ORSTROM, Paris. 569 pp.

HG40:12: Jim Duke's personal files

IJO13:168: Jim Duke's personal files

IJO16:204: Jim Duke's personal files

JAF38:688: Oszmianski, J. and Lee, C.Y. 1990. Inhibitory Effect of Phenolics on Carotene Bleaching in Vegetables. J. Agric. Food Chem. 38: 688-690.

JAF44:2057: Jim Duke's personal files

JAF47:397: Jim Duke's personal files

JAF48:235: Jim Duke's personal files

JAFC45:632: Jim Duke's personal files

JBH: Jeffery B. Harborne and H. Baxter, eds. 1983. Phytochemical Dictionary. A Handbook of Bioactive Compounds from Plants. Taylor & Frost, London. 791 pp.

JE26:76: Jim Duke's personal files

JE36:39: Jim Duke's personal files

JNM1:10: Jim Duke's personal files.

JNP42:399: Dasgupta, S., Ray, A. B., Bhattacharya, S. K., Bose, R. 1979. Constituents of Pachygone ovata and Pharmacological Action of its Major Leaf Alkaloid. J Nat Prod, 42(4): 399-406.

JNU: Jim Duke's personal files

K16299: Jim Duke's personal files

KCH: Huang, K. C. 1993. The Pharmacology of Chinese Herbs. CRC Press, Boca Raton, FL 388 pp.

LRN-DEC90: Lawrence Review of Natural Products, Dec-90.

LRN-SEP91: Lawrence Review of Natural Products, Sep-91.

M&R317: Jim Duke's personal files

M11: Merck 11th Edition

M29: Martindale's 29th

MAB: Mills, Simon and Bone, Kerry. 2,000. Phytotherapy. Churchill Livinston, Edinburgh.

MAR: Martindale's 28th

NIG: Nigg, H.N. and Seigler, D.S., eds. 1992. Phytochemical Resources for Medicine and Agriculture. Plenum Press, New York. 445 pp.

OHAI13:165: Jim Duke's personal files

PAM: Pizzorno, J.E. and Murray, M.T. 1985. A Textbook of Natural Medicine. John Bastyr College Publications, Seattle, Washington (Looseleaf).

PC27:973: Jim Duke's personal files

PC36:579: Ohnishi, M., Morishita, H., Iwahashi, H., Toda, S., Shirataki, Y., Kimura, M., and Kido, R. 1993. Inhibitory Effects of Chlorogenic Acids on Linoleic Acid Peroxidation and Haemolysis. Phytochemistry. 36(3): 579-583. 1994.

PCF:18: Ki Soon Rhee. Oilseed Food Ingredients Used To Minimize Oxidative Flavor Deterioration in Meat Products. Phenolic Compounds in Food and Their Effects on Health, Ch.18.

PCF:19: Hagerman, A.E. Tannin-Protein Interactions. Phenolic Compounds in Food and Their Effects on Health, Ch.19.

PCF:221: Jim Duke's personal files

PCF:25: McEvily, A.J., Iyengar, R., and Gross, A.T. Inhibition of Polyphenol Oxidase by Phenolic Compounds. Phenolic Compounds in Food and Their Effects on Health, Ch.25.

PCF:39,277: Jim Duke's personal files

PCF:44: Jim Duke's personal files

PCF:69: Phenolic Compounds in Food and Their Effects on Health, 69.

PHZ46:156: Pharmazie, 46: 156, 1991.

PJB1(1):169: Jim Duke's personal files

PM56(6):577: Jim Duke's personal files

PM56(6):645: Jim Duke's personal files

PM56:173: Jim Duke's personal files

PM57:A54: Planta Medica, 57: A54, 1991.

PM61:510: Jim Duke's personal files

PMID11199135: Jim Duke's personal files

PMP23:51: Jim Duke's personal files

POP:270: Jim Duke's personal files

PPL7:187: Jim Duke's personal files

PR4:73: Phytotherapy Research, 4: 73.

RWG17: Jim Duke's personal files

RWG27: Jim Duke's personal files

SHT76: Jim Duke's personal files

SKN43:99: Ichikawa, K., et al. 1991. Isolation and Structure Determination of Aldose Reductase Inhibitors from Traditional Thai Medicine, and Syntheses of Their Derivatives. Sankyo Kenkyusho Nempo, 43: 99-110.

WER: Werbach, M. 1993. Healing with Food. Harper Collins, New York, 443 pp.

WIC: Wichtl, M. 1984. Teedrogen. Ein Handbuch fur Apotheker und Arzte. Wissenschaftliche Verlagsgesellscharft. mbH Stuttgart. 393 pp.

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