Amazon CNS Support

120 capsules (650 mg each)

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

A synergistic formula of 6 rainforest botanicals traditionally used in South America for pain, nerve injuries and to calm overactive pain processing pathways.* For more information on the individual ingredients in Amazon CNS Support, follow the links provided below to the plant database files in the Tropical Plant Database.

Ingredients: A proprietary blend of pau d'arco, tayuya, manacá, mulungu, amor seco, and iporuru. To prepare this natural remedy yourself: Use one part for each plant shown in the list above. To make a small amount... "1 part" could be one tablespoon (you'd have 6 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce or one cup or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.

Suggested Use: Take 2 grams by weight (or about 1 teaspoon by volume) very 4-6 hours as needed, or as directed by a healthcare professional.

  • Not to be used during pregnancy or while breast-feeding.
  • Manacá has documented anticoagulant activity. People with blood disorders such as hemophilia should be monitored closely for this possible effect.
Drug Interactions: May potentiate anticoagulants, MAO-inhibitors and antihypertensive medications.

Other Practitioner Observations:
  • Manacá contains salicylate. Those with an allergy or sensitivity to salicylates or aspirin may be sensitive to this formula.
  • This formula may cause drowsiness at higher dosages. If this occurs; reduce the amount used.
  • Plants in this formula may reduce blood pressure (based on animal studies). Those with low blood pressure should be monitored for this possible effect.

Third-Party Published Research*

This rainforest formula has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.

Pau d'arco (Tabebuia impetiginosa)
Pau d'arco has demonstrated analgesic, antinociceptive and antiedematogenic actions in animal studies. An aqueous extract, administered orally to mice, reduced the nociception produced by acetic acid by 63.7%. The aqueous extract (200 and 400 mg/kg, p.o.) reduced formalin effects at the second phase of the experiment by 49.3% and 53.7%, respectively. Researchers in 2012 again documented the pain-relieving actions in mice and summarized their work saying: "The results suggest that the ethanolic extract of the inner bark of Tabebuia avellanedae has the potential to be developed as a therapeutic or supportive drug against diseases with accompanying pain and inflammation, including osteoarthritis."
Lee, M., et al. "Analgesic and anti-inflammatory effects in animal models of an ethanolic extract of Taheebo, the inner bark of Tabebuia avellanedae." Mol Med Report. 2012 Oct;6(4):791-6
Suo, M., et al. "Anti-inflammatory constituents from Tabebuia avellanedae." Fitoterapia. 2012 Dec;83(8):1484-8.
Byeon, S., et al. "In vitro and in vivo anti-inflammatory effects of taheebo, a water extract from the inner bark of Tabebuia avellanedae." J Ethnopharmacol. 2008 Sep 2;119(1):145-52.
Awale, S., et al. ”Nitric oxide (NO) production inhibitory constituents of Tabebuia avellanedae from Brazil.” Chem. Pharm. Bull. 2005; 53(6): 710-3.
Lee, J. H., et al. "Down-regulation of cyclooxygenase-2 and telomerase activity by beta-lapachone in human prostate carcinoma cells." Pharmacol. Res. 2005; 51(6): 553-60.
de Miranda, F. G., et al. “Antinociceptive and antiedematogenic properties and acute toxicity of Tabebuia avellanedae Lor. ex Griseb. inner bark aqueous extract.” BMC. Pharmacol. 2001; 1(1): 6.
Oga, S., et al. “Toxicidade e atividade anti-inflamatoria de Tabebuia avellanedae Lorentz (‘Ipe Roxo’).” Rev. Fac. Farm. Bioquim. 1969; 7: 4.

Tayuya (Cayaponia tayuya)
Novel cucurbitacins have been discovered in tayuya and named cayaponosides (24 distinct cayapon-osides have been discovered thus far). These phytochemicals have been documented to have antioxidant, anti-inflammatory and pain-relieving properties. Two animal studies, performed in the early 1990s, verified that tayuya provided analgesic and anti-inflammatory actions. One study documented that a root infusion given intragastrically to mice had an analgesic action. Another research group prepared the root in a methanol extract and reported anti-inflammatory actions when administered orally to mice.
Escandell, J. M., et al. "Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus." J Pharmacol Exp Ther. 2010 Feb;332(2):352-63.
Aquila, S., et al. "Anti-inflammatory activity of flavonoids from Cayaponia tayuya roots." J Ethnopharmacol. 2009 Jan 21;121(2):333-7.
Escandell, J. M., et al. "Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of TNF-{alpha} in T lymphocytes and macrophages." J. Pharmacol. Exp. Ther. 2006 Feb; 532(1-2): 145-54.
Escandell, J. M., et al. “Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis.” Eur. J. Pharmacol. 2006 Feb; 532(1-2): 145-54.
Recio, M. C., et al. “Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.” Planta Med. 2004; 70(5): 414-20.
Himeno, E., et al. “Structures of cayaponosides A, B, C and D, glucosides of new nor-cucurbitacins in the roots of Cayaponia tayuya.” Chem. Pharm. Bull. (Tokyo) 1992; 40(10): 2885–87.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake venom—I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86 (Suppl. 2): 203–5.
Rios, J. L., et al. “A study of the anti-inflammatory activity of Cayaponia tayuya root.” Fitoterapia 1990; 61(3): 275–78.
Faria, M. R. and E. P. Schenkel. “Caracterizacao de cucurbitacinas em especies vegetais cohecidas popularmente como taiuiá.” Ciencia e Cultura (São Paulo) 1987; 39: 970–73.
Bauer, R., et al. “Cucurbitacins and flavone C-glycosides from Cayaponia tayuya.” Phytochemisty. 1984: 1587–91.

Manacá (Brunfelsia uniflora)
Manacá contains a significant amount of scopoletin, a well known plant chemical with pain-relieving actions. In a 1991 clinical study with mice, manacá demonstrated pain-relieving and anti-inflammatory effects. An earlier (1977) study reported that manacá evidenced marked anti-inflammatory actions in rats—as well as central nervous system depressant and antipyretic actions.
Moon, P. D., et al. "Use of scopoletin to inhibit the production of inflammatory cytokines through inhibition of the IkappaB/NF-kappaB signal cascade in the human mast cell line HMC-1." Eur. J. Pharmacol. 2007 Jan; 555(2-3): 218-25.
Chang, T., et al. "Ameliorative Effects of Scopoletin from Crossostephium chinensis against Inflammation Pain and Its Mechanisms in Mice." Evid Based Complement Alternat Med. 2012: 595603.
Rollinger, J. M., et al. “Acetylcholinesterase inhibitory activity of scopolin and scopoletin discovered by virtual screening of natural products.” J. Med. Chem. 2004 Dec 2; 47(25): 6248-54.
Park, J. H., et al. “Antiinflammatory activity of Synurus deltoides.” Phytother. Res. 2004; 18(11): 930-3.
Kim, H. J., et al. “Scopoletin suppresses pro-inflammatory cytokines and PGE2 from LPS-stimulated cell line, RAW 264.7 cells.” Fitoterapia. 2004 Jun; 75(3-4): 261-6.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake venom–I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86: 203–5.
Iyer, R. P., et al. “Brunfelsia hopeana I: Hippocratic screening and antiinflammatory evaluation." Lloydia. 1977; 40(4): 356–60.
de Costa, A. O. “A pharmacologic study of manacá (Brunfelsia hopeana)." Bol. Assoc. Bras. Pharm. 1933; 14: 295–99

Mulungu (Erythrina mulungu)
Mulungu is documented with 20 isoquinoline alkaloids, many of which have demonstrated analgesic, anti-inflammatory, cardioactive, narcotic, and sedative activities. The traditional use of mulungu as a nervine for anxiety and stress has been validated by researchers in a recent (2002) study, where it was shown to alter anxiety-related responses. The researchers reported that mulungu had an effect similar to the commonly-prescribed anti-anxiety drug diazepam.
Santos Rosa, D., et al. "Erysothrine, an alkaloid extracted from flowers of Erythrina mulungu Mart. ex Benth: evaluating its anticonvulsant and anxiolytic potential." Epilepsy Behav. 2012 Mar;23(3):205-12.
Nagaraja, T., et al. "Anticonvulsant activity of Erythrina mysorensis bark extract in an animal model of epilepsy." J Pharmacol Pharmacother. 2012 Jan;3(1):62-4.
Faggion, S., et al. "Anticonvulsant profile of the alkaloids (+)-erythravine and (+)-11-?-hydroxy-erythravine isolated from the flowers of Erythrina mulungu Mart ex Benth (Leguminosae-Papilionaceae)." Epilepsy Behav. 2011 Mar;20(3):441-6.
Vasconcelos, S. M., et al. "Anticonvulsant activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu." J. Ethnopharmacol. 2007 Mar 21;110(2):271-4.
Marchioro, M., et al. “Anti-nociceptive activity of the aqueous extract of Erythrina velutina leaves.” Fitoterapia. 2005 Dec; 76(7-8): 637-42.
Chaddock, J. A., et al. “Retargeted clostridial endopeptidases: inhibition of nociceptive neurotransmitter release in vitro, and antinociceptive activity in in vivo models of pain.” Mov. Disord. 2004 Mar; 19 Suppl 8: S42-7.
Weber, D., et al. “Phomol, a new antiinflammatory metabolite from an endophyte of the medicinal plant Erythrina crista-galli.” J. Antibiot. 2004; 57(9): 559-63.
Vasconcelos, S. M., et al. “Antinociceptive activities of the hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice.” Biol. Pharm. Bull. 2003; 26(7): 946-9.
Njamen, D., et al. “Anti-inflammatory activity of erycristagallin, a pterocarpene from Erythrina mildbraedii.” Eur. J. Pharmacol. 2003 May; 468(1): 67-74.
Duggan, M. J., et al. “Inhibition of release of neurotransmitters from rat dorsal root ganglia by a novel conjugate of a Clostridium botulinum toxin A endopeptidase fragment and Erythrina cristagalli lectin.” J. Biol. Chem. 2002 Sep; 277(38): 34846-52.

Amor Seco (Desmodium adscendens)
Amor seco has been documented in animal studies to have analgesic actions as well as anticonvulsant, anti-inflammatory, antispasmodic, and anti-anaphylactic actions.
Rastogi, S., et al. "An ethnomedicinal, phytochemical and pharmacological profile of Desmodium gangeticum (L.) DC. and Desmodium adscendens (Sw.) DC." J Ethnopharmacol. 2011 Jun 22;136(2):283-96.
Irié-N'guessan, G., et al. "Tracheal relaxation of five Ivorian anti-asthmatic plants: role of epithelium and K? channels in the effect of the aqueous-alcoholic extract of Dichrostachys cinerea root bark." J Ethnopharmacol. 2011 Nov 18;138(2):432-8.
N’Gouemo, P., et al. "ffects of an ethanolic extract of Desmodium adscendens on central nervous system in rodents." J. Ethnopharmacol. 1996; 52(2): 77–83.
McManus, O. B., et al. "n activator of calcium-dependent potassium channels isolated from a medicinal herb." Biochemistry 1993; 32(24): 6128–33.
Addy, M. E., et al. “Some secondary plant metabolites in Desmodium adscendens and their effects on arachidonic acid metabolism.” Prostaglandins Leukotrienes Essent. Fatty Acids 1992; 47(1): 85–91.
Boye, G. and O. Ampopo. “Plants and traditional medicine in Ghana.” Economic and Medicinal Plant Research 4 1990. Devon, England: Academic Press Ltd.: 33–4.
Addy, M. E., et al. “Effect of Desmodium adscendens fraction 3 on contractions of respiratory smooth muscle.” J. Ethnopharmacol. 1990; 29(3): 325–35.

Iporuru (Alchornea castaneifolia)
Several animal studies confirm iporuru's analgesic, anti-inflammatory and COX-inhibition actions. In Peruvian herbal medicine systems it is a popular herbal remedy for arthritic and rheumatic aches and pains.
Okoye, F., et al. "Topical anti-inflammatory constituents of lipophilic leaf fractions of Alchornea floribunda and Alchornea cordifolia." Nat Prod Res. 2011 Dec;25(20):1941-9.
Lopes, F., et al. "Anti-inflammatory activity of Alchornea triplinervia ethyl acetate fraction: inhibition of Hv(2)Ov(2), NO and TNF-?." Pharm Biol. 2010 Dec;48(12):1320-7.
Kouakou-Siransy, G., et al. "Effects of Alchornea cordifolia on elastase and superoxide anion produced by human neutrophils." Pharm Biol. 2010 Feb;48(2):128-33. Okoye, F., et al. "Anti-inflammatory and membrane-stabilizing stigmastane steroids from Alchornea floribunda leaves." Planta Med. 2010 Feb;76(2):172-7.
Manga, H., et al. "Anti-inflammatory compounds from leaves and root bark of Alchornea cordifolia (Schumach. & Thonn.) Müll. Arg." J Ethnopharmacol. 2008 Jan 4;115(1):25-9.
Manga, H.M., et al. “In vivo anti-inflammatory activity of Alchornea cordifolia (Schumach. & Thonn.) Mull. Arg. (Euphorbiaceae).” J. Ethnopharmacol. 2004 Jun; 92(2-3): 209-14.
Osadebe, P. O., et al. “Anti-inflammatory effects of crude methanolic extract and fractions of Alchornea cordifolia leaves.” J. Ethnopharmacol. 2003 Nov; 89(1):19-24.
Tona, L., et al. “Antiamoebic and spasmolytic activities of extracts from some antidiarrhoeal traditional preparations used in Kinshasa, Congo.” Phytomedicine. 2000 Mar; 7(1): 31-8.
Dunstan, C. A., et al. “Evaluation of some Samoan and Peruvian medicinal plants by prostaglandin biosynthesis and rat ear oedema assays.” J. Ethnopharmacol. 1997; 57: 35–56.
Ogungbamila, F. O., et al. “Smooth muscle–relaxing flavonoids from Alchornea cordifolia.” Acta Pharm. Nord. 1990; 2(6): 421–22.
Persinos-Perdue, G., et al. “Evaluation of Peruvian folk medicine by the natural products research laboratories.” Abstra. Joint Meeting American Society of Pharmacognosy and Society for Economic Botany, Boston, 1981; (5) 13

*The statements contained herein have not been evaluated
by the Food and Drug Administration. The information contained herein is intended and provided for education, research, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plants and/or formulas described herein are not intended to treat, cure, diagnose, mitigate or prevent any disease and no medical claims are made.
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Last updated 1-9-2013