cat's claw, uncaria, tomentosa, capsules, uno de gato, Raintree, saventaro, villacora, samento, immune, herbs, vine, bark, alkaloids, Raintree, Peruvian, rainforest, rain forest Cat's Claw Extract

Uncaria tomentosa

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search for products available from other suppliers or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

Cat's claw has grown quite popular in the natural products industry and is mostly taken today to boost immune function, as an all over tonic and preventative to stay healthy, for arthritis and inflammation, for bowel and colon problems, and as an complementary therapy for cancer.* Are you looking for a "TOA-Free" product? For more complete information follow this link to read about The TOA / POA Controversy.

For more complete information on this unique rainforest plant, please see the Plant Database File on Cat's Claw. To see pictures of cat's claw growing in the Peruvian Amazon, click here. More information on cat's claw can also be found in the new Anti-Cancerous Guide

Traditional Uses:* as an immune stimulant and an adjunctive therapy for cancer (to reduce side effects of chemotherapy and protect cells); as a bowel cleanser and anti-inflammatory for Crohn's, colitis, diverticulitis, irritable bowel syndrome (IBS), and other bowel problems; as an anti-inflammatory for arthritis (all kinds) and muscle pains/strains/injuries; as a general daily tonic (to tone, balance, and strengthen all body functions); for stomach ulcers and ulcerative colitis and as an ulcer preventative/ stomach and bowel protector)

Ingredients: Cat's claw extracted in oranic cider vinegar and honey. To prepare this natural remedy yourself: combine 1/2 cup cat's claw vine powder and 3 cups apple cider vinegar in a non-aluminum sauce pan. Bring to a boil, then cover pot and reduce heat to low. Simmer covered for 2 hours. Remove from heat and let cool. Strain out powder and measure remaining decoction. To two parts decoction, add 1 part honey (if you had 2 cups of the decoction, add 1 cup honey), Store in the refrigerator.

Suggested Use: Take 1/2 to 1 tsp daily, or as directed by a healthcare professional.

  • Cat's claw has been documented with immunostimulant effects and is contraindicated before or following any organ or bone marrow transplant or skin graft.
  • Cat's claw has been documented with antifertility properties and is contraindicated in persons seeking to get pregnant.
  • Cat's claw has been documented with chemicals which can reduce platelet aggregation and thin the blood. It is contraindicated in persons with bleeding disorders such as hemophilia.
Drug Interactions: Based upon animals studies, cat's claw may protect against gastrointestinal damage associated with NSAIDs such as ibuprofen. May potentiate coumadin and blood-thinning drugs.

Other Practitioner Observations:
  • Cat's claw requires sufficient stomach acid to help break down the tannins and alkaloids during digestion and to aid in absorption. Avoid taking capsules at the same time as antacids.
  • Large dosages of cat's claw (3-4 gram dosages) have been reported to cause some abdominal pain or gastrointestinal problems including diarrhea (due to the tannin content of the vine bark). The diarrhea or loose stools tend to be mild and go away with continued use. Discontinue use or reduce dosage if diarrhea persists longer than 3-4 days.

Third-Party Published Research*

All available third-party research on cat's claw can be found at PubMed/Medline. A partial listing of the published research on cat's claw is shown below:

Immunostimulant & Immunomodulatory Actions:
Domingues, A., et al. "Prevention of experimental diabetes by Uncaria tomentosa extract: Th2 polarization, regulatory T cell preservation or both?" J Ethnopharmacol. 2011 Sep 1;137(1):635-42.
Domingues, A., et al. "Uncaria tomentosa aqueous-ethanol extract triggers an immunomodulation toward a Th2 cytokine profile." Phytother Res. 2011 Aug;25(8):1229-35
Erowele, G., et al. "Pharmacology and therapeutic uses of cat's claw." Am. J. Health Syst. Pharm. 2009 Jun 1; 66(11): 992-5.
Reis, S., et al. "Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2." Int. Immunopharmacol. 2008; 8(3): 468-76.
Holderness, J., et al. "Select plant tannins induce IL-2Ralpha up-regulation and augment cell division in gammadelta T cells." J. Immunol. 2007 Nov; 179(10): 6468-78.
Groom, S., et al. "The potency of immunomodulatory herbs may be primarily dependent upon macrophage activation." J. Med. Food. 2007 Mar; 10(1): 73-9.
Spelman, K., et al. "Modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators." Altern. Med. Rev. 2006 Jun; 11(2): 128-50.
Eberlin, S., et al. “Uncaria tomentosa extract increases the number of myeloid progenitor cells in the bone marrow of mice infected with Listeria monocytogenes.” Int. Immunopharmacol. 2005; 5(7-8):1235-46.
Deharo, E., et al. ”In vitro immunomodulatory activity of plants used by the Tacana ethnic group in Bolivia.” Phytomedicine. 2004 Sep; 11(6): 516-22.
Lamm, S., et al, “Persistent response to pneumococcal vaccine in individuals supplemented with a novel water soluble extract of Uncaria tomentosa, C-Med-100." Phytomedicine. 2001; 8(4): 267–74.
Sheng Y, et al., “Treatment of chemotherapy-induced leukopenia in a rat model with aqueous extract from Uncaria tomentosa.” Phytomedicine. 2000; 7(2): 137–43.
Lemaire, I., et al. “Stimulation of interleukin-1 and -6 production in alveolar macrophages by the neotropical liana, Uncaria tomentosa (una de gato).” J. Ethnopharmacol. 1999; 64(2): 109–15.
Marina, M. D. “Evaluacion de la actividal immunoestimulante de Uncaria tomentosa (Willd.) DC. Una de gato en ratones albinos." Biodiversidad Salud. 1998; 1(1): 16–19.
Keplinger, H., et al. “Oxindole alkaloids having properties stimulating the immunologic system and preparation containing same.” United States patent 5,302,611; April 12, 1994
Wagner, H., et al. “Die Alkaloide von Uncaria tomentosa und ihre Phagozytose-steigernde Wirkung." Planta Med. 1985; 51: 419–23.
Hemingway, S. R. and J. D. Phillipson. “Alkaloids from South American species of Uncaria (Rubiaceae)." J. Pharm. Pharmacol. 1974 suppl.; 26: 113p.

Anti-inflammatory Actions:
Akhtar, N., et al. "Current nutraceuticals in the management of osteoarthritis: a review." Ther Adv Musculoskelet Dis. 2012 Jun;4(3):181-207.
Rojas-Duran, R., et al. "Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark." J Ethnopharmacol. 2012 Oct 11;143(3):801-4.
Allen-Hall, L., et al. "Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB." J. Ethnopharmacol. 2010 Feb 17;127(3):685-93.
Zeng, K., et al. "Synthesis and biological evaluation of quinic acid derivatives as anti-inflammatory agents." Bioorg. Med. Chem. Lett. 2009 Sep 15; 19(18): 5458-60.
Erowele, G., et al. "Pharmacology and therapeutic uses of cat's claw." Am. J. Health Syst. Pharm. 2009 Jun 1; 66(11): 992-5.
Amaral, S., et al. "Plant extracts with anti-inflammatory properties--a new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationships." Bioorg. Med. Chem. 2009 Mar; 17(5): 1876-83.
Yuan, D., et al. "Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism." Int. Immunopharmacol. 2009 Dec; 9(13-14):1549-54.
Pero, R. "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals." United States Patent No. 7,595,064. September 29, 2009
Hardin, S. R. "Cat's claw: An Amazonian vine decreases inflammation in osteoarthritis." Complement. Ther. Clin. Pract. 2007 Feb; 13(1): 25-8.
Allen-Hall, L., et al. "Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha." J. Ethnopharmacol. 2007 Jan; 109(2): 312-7.
Badilla, B., et al. "Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts." Rev. Biol. Trop. 2006 Jun; 54(2):245-52.
Miller, M. J., et al. "The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta." BMC Complement. Altern. Med. 2006 Apr; 6: 13.
Miller, M. J., et al. "Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]." J. Inflamm. 2005 Oct; 2:11.
Valerio, L. G., et al. "Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii): a critical synopsis." Toxicol. Rev. 2005; 24(1): 11-35.
Setty, A. R., et al. "Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects." Semin. Arthritis Rheum. 2005; 34(6): 773-84.
Sheng, Y., et al. “An active ingredient of Cat's Claw water extracts: identification and efficacy of quinic acid.” J. Ethnopharmacol. 2005 Jan 15; 96(3):
Aguilar, J. L., et al. “Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae).” J. Ethnopharmacol. 2002; 81(2): 271–76.
Sandoval, M., et al., “Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content." Phytomedicine. 2002; 9(4): 325–37.
Mur, E., et al. “Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis.” J. Rheumatol. 2002 Apr; 29(4): 678–81.
Sandoval-Chacon, M., et al. “Anti-inflammatory actions of cat’s claw: the role of NF-kappaB.” Aliment. Pharmacol. Ther. 1998; 12(12): 1279–89.
Recio, M. C., et al. “Structural requirements for the anti-inflammatory activity of natural triterpenoids.” Planta Med. 1995; 61(2): 182–85.
Aquino, R., et al. “Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa." J. Nat. Prod. 1991; 54: 453–59.
Cerri, R., et al. “New quinovic acid glycosides from Uncaria tomentosa." J. Nat. Prod. 1988; 51: 257–61.

Anticancerous & Antitumor Actions:
Santos Araújo Mdo, C., et al. "Uncaria tomentosa-Adjuvant Treatment for Breast Cancer: Clinical Trial." Evid Based Complement Alternat Med. 2012;2012:676984.
Farias, I., et al. "Uncaria tomentosa for Reducing Side Effects Caused by Chemotherapy in CRC Patients: Clinical Trial." Evid Based Complement Alternat Med. 2012;2012:892182.
Anter, J., et al.. "Antigenotoxicity, cytotoxicity, and apoptosis induction by apigenin, bisabolol, and protocatechuic acid." J Med Food. 2011 Mar;14(3):276-83.
Gurrola-Díaz, C., et al. "Inhibitory mechanisms of two Uncaria tomentosa extracts affecting the Wnt-signaling pathway." Phytomedicine. 2011 Jun 15;18(8-9):683-90.
Pilarski, R., et al. "Anticancer activity of the Uncaria tomentosa (Willd.) DC. preparations with different oxindole alkaloid composition." Phytomedicine. 2010 Dec 1;17(14):1133-9.
Dreifuss, A., et al. "Antitumoral and antioxidant effects of a hydroalcoholic extract of cat's claw (Uncaria tomentosa) (Willd. Ex Roem. & Schult) in an in vivo carcinosarcoma model." J Ethnopharmacol. 2010 Jul 6;130(1):127-33
García Giménez, D., et al. "Cytotoxic effect of the pentacyclic oxindole alkaloid mitraphylline isolated from Uncaria tomentosa bark on human ewing's sarcoma and breast cancer cell lines." Planta Med. 2010 Feb; 76(2):133-6.
Rinner, B., et al. "Antiproliferative and pro-apoptotic effects of Uncaria tomentosa in human medullary thyroid carcinoma cells." Anticancer Res. 2009; 29(11): 4519-28.
Erowele, G., et al. "Pharmacology and therapeutic uses of cat's claw." Am. J. Health Syst. Pharm. 2009 Jun 1; 66(11): 992-5.
Pilarski, R., et al. "Antiproliferative activity of various Uncaria tomentosa preparations on HL-60 promyelocytic leukemia cells." Pharmacol. Rep. 2007 Sep-Oct; 59(5): 565-72.
Chen, A., et al. "Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells." Food Chem. Toxicol. 2007; 45(11): 2206-18.
García Prado, E., et al. "Antiproliferative effects of mitraphylline, a pentacyclic oxindole alkaloid of Uncaria tomentosa on human glioma and neuroblastoma cell lines." Phytomedicine. 2007; 14(4): 280-4.
Gonzales, G.F., et al. "Medicinal plants from Peru: a review of plants as potential agents against cancer." Anticancer Agents Med. Chem. 2006 Sep; 6(5): 429-44.
De Martino, L., et al. "Proapoptotic effect of Uncaria tomentosa extracts." J. Ethnopharmacol. 2006 Aug; 107(1): 91-4.
Bacher, N., et al. "Oxindole alkaloids from Uncaria tomentosa induce apoptosis in proliferating, G0/G1-arrested and bcl-2-expressing acute lymphoblastic leukaemia cells." Br. J. Haematol. 2006 Mar; 132(5): 615-22.
Riva, L., et al. “The antiproliferative effects of Uncaria tomentosa extracts and fractions on the growth of breast cancer cell line." Anticancer Res. 2001; 21(4A): 2457–61.
Muhammad, I., et al. “Investigation of Una de Gato I. 7-Deoxyloganic acid and 15N NMR spectroscopic studies on pentacyclic oxindole alkaloids from Uncaria tomentosa." Phytochemistry. 2001; 57(5): 781–5.
Sheng, Y., et al. “Induction of apoptosis and inhibition of proliferation in human tumor cells treated with extracts of Uncaria tomentosa." Anticancer Res. 1998; 18(5A): 3363–68.
Salazar, E. L., et al. “Depletion of specific binding sites for estrogen receptor by Uncaria tomentosa." Proc. West. Pharmacol. Soc. 1998; 41(1): 123–124.
Stuppner, H., et al. “A differential sensitivity of oxindole alkaloids to normal and leukemic cell lines.” Planta Med. (1993 suppl.); 59: A583.
Rizzi, R., et al. “Mutagenic and antimutagenic activities of Uncaria tomentosa and its extracts." J. Ethnopharmacol. 1993; 38: 63–77.
Peluso, G., et al. “Effetto antiproliferativo su cellule tumorali di estrattie metaboliti da Uncaria tomentosa. Studi in vitro sulla loro azione DNA polimerasi.” 11 Congreso Italo-Peruano de Etnomedicina Andina, Lima, Peru, October 27–30, 1993, 21–2.
Rizzi, R., et al. “Bacterial cytotoxicity, mutagenicity and antimutagenicity of Uncaria tomentosa and its extracts. Antimutagenic activity of Uncaria tomentosa in humans." Premiere Colloque Européan d'Ethnopharmacologie, Metz, France, March 22–24, 1990.

Cellular Protective & Antioxidant Actions:
Zhang, L., et al. "Quinic Acid Could Be a Potential Rejuvenating Natural Compound by Improving Survival of Caenorhabditis elegans under Deleterious Conditions." Rejuvenation Res. 2012 Sep 24
Bukowska, B., et al. "Uncaria tomentosa extracts protect human erythrocyte catalase against damage induced by 2,4-D-Na and its metabolites." Food Chem Toxicol. 2012 Jun;50(6):2123-7.
Farias, I., et al. "Uncaria tomentosa stimulates the proliferation of myeloid progenitor cells." J Ethnopharmacol. 2011 Sep 1;137(1):856-63.
Guthrie, O., et al. "Carboxy alkyl esters of Uncaria tomentosa augment recovery of sensorineural functions following noise injury." Brain Res. 2011 Aug 17;1407:97-106.
Bors, M., et al. "Protective activity of the Uncaria tomentosa extracts on human erythrocytes in oxidative stress induced by 2,4-dichlorophenol (2,4-DCP) and catechol." Food Chem Toxicol. 2011 Sep;49(9):2202-11.
de Fátima, F., et al. "[Uncaria tomentosa and acute ischemic kidney injury in rats]." Rev Esc Enferm USP. 2011 Mar;45(1):194-8
Filip, A., et al. "Photochemoprevention of cutaneous neoplasia through natural products." Exp. Oncol. 2009 Mar; 31(1): 9-15.
Amaral, S., et al. "Plant extracts with anti-inflammatory properties--a new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationships." Bioorg. Med. Chem. 2009 Mar; 17(5): 1876-83.
Paniagua-Pérez, R., et al. "Antigenotoxic, antioxidant and lymphocyte induction effects produced by pteropodine." Basic Clin. Pharmacol. Toxicol. 2009; 104(3): 222-7.
Chen, A., et al. "Induction of apoptosis by Uncaria tomentosa through reactive oxygen species production, cytochrome c release, and caspases activation in human leukemia cells." Food Chem. Toxicol. 2007; 45(11): 2206-18.
Mammone, T., et al. "A water soluble extract from Uncaria tomentosa (Cat's Claw) is a potent enhancer of DNA repair in primary organ cultures of human skin." Phytother. Res. 2006; 20(3): 178-83.
Kuras, M., et al. "Changes in chromosome structure, mitotic activity and nuclear DNA content from cells of Allium Test induced by bark water extract of Uncaria tomentosa (Willd.) DC." J. Ethnopharmacol. 2006 Sep; 107(2): 211-21.
Pilarski, R., et al. "Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC." J. Ethnopharmacol. 2006 Mar; 104(1-2): 18-23.
Cisneros, F. J., et al. “An Uncaria tomentosa (cat's claw) extract protects mice against ozone-induced lung inflammation.” J. Ethnopharmacol. 2005 Jan; 96(3): 355-64.
Goncalves, C., et al. “Antioxidant properties of proanthocyanidins of Uncaria tomentosa bark decoction: a mechanism for anti-inflammatory activity.” Phytochemistry. 2005; 66(1): 89-98.
Romero-Jimenez, M., et al. “Genotoxicity and anti-genotoxicity of some traditional medicinal herbs.” Mutat. Res. 2005 Aug; 585(1-2): 147-55.
Pilarski, R., et al. “Antioxidant activity of ethanolic and aqueous extracts of Uncaria tomentosa (Willd.) DC.” J. Ethnopharmacol. 2005 Sep 29;
Sheng, Y., et al. “DNA repair enhancement of aqueous extracts of Uncaria tomentosa in a human volunteer study." Phytomedicine. 2001; 8(4): 275–82.
Sheng, Y., et al. “Enhanced DNA repair, immune function and reduced toxicity of C-Med-100, a novel aqueous extract from Uncaria tomentosa." J. Ethnopharmacol. 2000; 69(2): 115–26.
Sandoval, M., et al. “Cat’s claw inhibits TNFalpha production and scavenges free radicals: role in cytoprotection.” Free Radic. Biol. Med. 2000; 29(1): 71–8.
Desmarchelier, C., et al. “Evaluation of the in vitro antioxidant activity in extracts of Uncaria tomentosa (Willd.) DC." Phytother. Res. 1997; 11(3): 254–256.
Chan-Xun, C., et al. “Inhibitory effect of rhynchophylline on platelet aggregation and thrombosis.” Acta Pharmacologica Sinica 1992; 13(2): 126–30.

Actions on the Brain, Memory & Alzheimer's:
Snow, A., et al. "Compounds, compositions and methods for the treatment of amyloid diseases and synucleinopathies such as Alzheimer's disease, type 2 diabetes, and Parkinson's disease." United States Patent No. 7,514,583 April 7, 2009
Castillo, G., et al. "Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants." United States Patent No. 7,314,642 January 1, 2008.
Frackowiak, T., et al. "Binding of an oxindole alkaloid from Uncaria tomentosa to amyloid protein (Abeta1-40)." Z. Naturforsch C. 2006 Nov-Dec; 61(11-12): 821-6.
Jurgensen, S., et al. “Involvement of 5-HT2 receptors in the antinociceptive effect of Uncaria tomentosa.” Pharmacol. Biochem. Behav. 2005 Jul; 81(3): 466-77.
Kang, T. H., et al. “Pteropodine and isopteropodine positively modulate the function of rat muscarinic M(1) and 5-HT(2) receptors expressed in Xenopus oocyte.” Eur. J. Pharmacol. 2002 May; 444(1-2): 39-45.
Mohamed, A. F., et al. “ Effects of Uncaria tomentosa total alkaloid and its components on experimental amnesia in mice: elucidation using the passive avoidance test.” J. Pharm. Pharmacol. 2001; 52(12): 1553–61.
Roth, B. L., et al. “Insights into the structure and function of 5-HT(2) family serotonin receptors reveal novel strategies for therapeutic target development.” Expert Opin. Ther. Targets 2001 Dec; 5(6): 685-695.
Castillo, G. "Methods of isolation of amyloid inhibitory ingredients within Uncaria tomentosa." US Patent No 7,029,710, April, 18, 2006.
Castillo, G. " Methods of isolating amyloid-inhibiting compounds and use of compounds isolated from Uncaria tomentosa and related plants." US Patent No. 6,929,808, August 16, 2005.
Castillo, G., et al. “Pharmaceutical compositions containing Uncaria tomentosa extract for treating Alzheimer's disease and other amyloidoses." Patent-Pct. Int. Paol. 1998; 00 33,659: 67pp.

Antimicrobial Actions:
Herrera, D., et al. "In vitro antimicrobial activity of phytotherapic Uncaria tomentosa against endodontic pathogens." J Oral Sci. 2010 Sep;52(3):473-6.
Chen, X., et al. "Effects of rhynchophylline and isorhynchophylline on nitric oxide and endothelin-1 secretion from RIMECs induced by Listeriolysin o in vitro." Vet. Microbiol. 2009 Nov 26.
Reis, S., et al. "Immunomodulating and antiviral activities of Uncaria tomentosa on human monocytes infected with Dengue Virus-2." Int. Immunopharmacol. 2008; 8(3): 468-76.
Ccahuana-Vasquez, R., et al. "Antimicrobial activity of Uncaria tomentosa against oral human pathogens." Braz. Oral Res. 2007 Jan-Mar; 21(1): 46-50.
Kloucek, P., et al. “Antibacterial screening of some Peruvian medicinal plants used in Calleria District.” J. Ethnopharmacol. 2005 Jun; 99(2): 309-12.
Garcia, R., et al. “Antimicrobial activity of isopteropodine.” Z. Naturforsch. 2005; 60(5-6): 385-8.
Aquino, R., et al. “Plant metabolites. Structure and in vitro antiviral activity of quinovic acid glycosides from Uncaria tomentosa and Guettarda platypoda." J. Nat. Prod. 1989; 4(52): 679–85.

Actions Against Endometriosis:
Nogueira, N., et al. "Experimental endometriosis reduction in rats treated with Uncaria tomentosa (cat's claw) extract." Eur J Obstet Gynecol Reprod Biol. 2011 Feb;154(2):205-8.

Toxicity Studies & Reviews:
Bors, M., et al. "Evaluation of the effect of Uncaria tomentosa extracts on the size and shape of human erythrocytes (in vitro)." Environ Toxicol Pharmacol. 2012 Mar;33(2):127-34.
Bors, M., et al. "Studies of biological properties of Uncaria tomentosa extracts on human blood mononuclear cells." J Ethnopharmacol. 2012 Aug 1;142(3):669-78.
Erowele, G., et al. "Pharmacology and therapeutic uses of cat's claw." Am. J. Health Syst. Pharm. 2009 Jun 1; 66(11): 992-5.
Pilarski, R., et al. "Evaluation of biological activity of Uncaria tomentosa (Willd.) DC. using the chicken embryo model." Folia Biol. (Krakow). 2009; 57(3-4): 207-12..
Kuras, M., et al. "Effect of Alkaloid-Free and Alkaloid-Rich preparations from Uncaria tomentosa bark on mitotic activity and chromosome morphology evaluated by Allium Test." J. Ethnopharmacol. 2009; 121(1): 140-7.

Antifertility Action:
Nogueira Neto, J., et al. "Contraceptive effect of Uncaria tomentosa (cat's claw) in rats with experimental endometriosis." Acta Cir Bras. 2011;26 Suppl 2:15-9.

Possible Drug Interactions:
Quilez, A., et al. "Uncaria tomentosa (Willd. ex. Roem. & Schult.) DC. and Eucalyptus globulus Labill. interactions when administered with diazepam." Phytother Res. 2012 Mar;26(3):458-61.
Cosentino, C., et al. "Reversible worsening of Parkinson disease motor symptoms after oral intake of Uncaria tomentosa (cat's claw)." Clin. Neuropharmacol. 2008 Sep-Oct; 31(5): 293-4.
López Galera, R., et al. "Interaction between cat's claw and protease inhibitors atazanavir, ritonavir and saquinavir." Eur. J. Clin. Pharmacol. 2008; 64(12): 1235-6.
Moreno, S., et al. "Effect of oral ingestion of an extract of the herb Uncaria tomentosa on the biodistribution of sodium pertechnetate in rats." Braz. J. Med. Biol Res. 2007; 40(1): 77-80.

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Last updated 12-30-2012