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Chanca Piedra Powder Phyllanthus niruri1 Pound (16 oz) Buy Now
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Purchase a one pound package of Raintree's sustainably harvested pure chanca piedra herb powder - rich in active and beneficial phytochemicals that occur naturally in this plant. This plant has been milled into a fine powder which is suitable to stuff into capsules or to prepare your own teas, tinctures or extracts. Raintree's chanca piedra has been sustainably wild-harvested in the Amazon Rainforest (without any pesticides or fertilizers). Chanca piedra means "stone breaker" throughout South America and the Amazon.* To see pictures of chanca piedra, click here.
Traditional Uses:* for kidney stones and gallstones (active stones and as a preventative); to tone, balance, strengthen, detoxify and protect the kidneys and to reduce uric acid and increase urination; to tone, balance, strengthen, detoxify, and protect the liver (and to balance liver enzymes)
For more information about Chanca Piedra (Phyllanthus niruri), please refer to the Database File for Chanca Piedra in the Tropical Plant Database. For general information on Raintree's available bulk plants and sustainable harvesting practices, please refer to Main Page for Bulk Plants.
This bulk one pound package retails for $28.00.
Purchase Chanca Piedra Powder Now
Print a PDF Chanca Piedra Brochure
Ingredients: 100% pure chanca piedra whole herb (Phyllanthus niruri). No binders, fillers or additives are used.
Suggested Use: This plant is best prepared as an infusion (tea): Use one teaspoon of powder for each cup of water. Pour boiling water over herb in cup and allow to steep 10 minutes. Strain tea (or allow settled powder to remain in the bottom of cup) and drink warm. It is traditionally taken in 1 cup dosages, 2-3 times daily.
Contraindications: None reported.
Drug Interactions: None reported; however, it might potentiate antihypertensive and diabetic drugs.
Other Observations:
- Chanca piedra has been documented to reduce blood pressure in animal studies. Individuals with low blood pressure should be monitored for this possible effect.
- Chanca piedra has been documented with female antifertility effects in one mouse study. The use of the plant is probably contraindicated in women seeking pregnancy.
- This plant has demonstrated hypoglycemic activity in animal studies. Individuals with hypoglycemia should be monitored more closely for this possible effect.
RELATED PRODUCTS:
Chanca piedra can be found as an ingredient in these proprietary Raintree formulas:
Chanca Piedra Tech Report -- A FREE Technical Plant Data Report is available for chanca piedra.
Third-Party Published Research*
This Raintree product has not been the subject of any clinical research.
All available third-party research on chanca piedra can be found at PubMed/Medline.
A partial listing of the published research on chanca piedra is shown below:
Actions on Kidney Stones & Uric Acid:
Murugaiyah, V., et al. "Mechanisms of antihyperuricemic effect of Phyllanthus niruri and its lignan constituents."
J. Ethnopharmacol. 2009 Jul; 124(2): 233-9.
Schuler, T., et al. "Medical expulsive therapy as an adjunct to improve shockwave lithotripsy outcomes: a systematic review and meta-analysis." J. Endourol. 2009; 23(3): 387-93.
Kieley, S., et al. "Ayurvedic medicine and renal calculi." J. Endourol. 2008; 22(8): 1613-6.
Wright, C., et al. "Herbal medicines as diuretics: a review of the scientific evidence." J. Ethnopharmacol. 2007 Oct; 114(1) :1-31.
Murugaiyah V, et al. "Antihyperuricemic lignans from the leaves of Phyllanthus niruri." Planta Med. 2006 Nov; 72(14): 1262-7.
Micali, S., et al. "Can Phyllanthus niruri affect the efficacy of extracorporeal shock wave lithotripsy for renal stones? A randomized, prospective, long-term study." J. Urol. 2006 Sep; 176(3): 1020-2.
Barros, M. E., et al. "Effect of extract of Phyllanthus niruri on crystal deposition in experimental urolithiasis." Urol. Res. 2006 Dec; 34(6): 351-7.
Nishiura, J. L., et al. “Phyllanthus niruri normalizes elevated urinary calcium levels in calcium stone forming (CSF) patients.” Urol. Res. 2004 Oct; 32(5): 362-6.
Barros, M. E., et al. “Effects of an aqueous extract from Phyllanthus niruri on calcium oxalate crystallization in vitro.” Urol. Res. 2003; 30(6): 374-9.
Freitas, A. M., et al. “The effect of Phyllanthus niruri on urinary inhibitors of calcium oxalate crystallization and other factors associated with renal stone formation.” B. J. U. Int. 2002; 89(9): 829–34.
Campos, A. H., et al. “Phyllanthus niruri inhibits calcium oxalate endocytosis by renal tubular cells: its role in urolithiasis.” Nephron. 1999; 81(4): 393–97.
Antispasmodic, Pain-Relieving, & Anti-inflammatory Actions:
Lai, C., et al. "Inhibition of Helicobacter pylori-induced inflammation in human gastric epithelial AGS cells by Phyllanthus urinaria extracts." J. Ethnopharmacol. 2008 Aug; 118(3): 522-6.
Dirjomuljono, M., et al. "Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract." Int. J. Clin. Pharmacol. Ther. 2008; 46(6): 295-306.
Fang, S., et al. "Anti-oxidant and inflammatory mediator's growth inhibitory effects of compounds isolated from Phyllanthus urinaria." J. Ethnopharmacol. 2008 Mar; 116(2): 333-40.
Kassuya, C. A., et al. "Antiinflammatory and antiallodynic actions of the lignan niranthin isolated from Phyllanthus amarus. Evidence for interaction with platelet activating factor receptor." Eur. J. Pharmacol. 2006 Sep; 546(1-3): 182-8.
Iizuka, T., et al. “Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri.” Biol. Pharm. Bull. 2006; 29(1): 177-9.
Kassuya, C.A., et al. “Anti-inflammatory properties of extracts, fractions and lignans isolated from Phyllanthus
amarus.” Planta Med. 2005; 71(8): 721-6.
Kiemer, A. K., et al. “Phyllanthus amarus has anti-inflammatory potential by inhibition of iNOS, COX-2, and
cytokines via the NF-kappaB pathway.” J. Hepatol. 2003; 38(3): 289-97.
Santos, A. R., et al. “Antinociceptive properties of extracts of new species of plants of the genus Phyllanthus
(Euphorbiaceae).” J. Ethnopharmacol. 2000; 72(1/2): 229–38.
Miguel, O. G., et al. “Chemical and preliminary analgesic evaluation of geraniin and furosin isolated from
Phyllanthus sellowianus.” Planta Med. 1996; 62(2): 146–49.
Santos, A. R., et al. “Analysis of the mechanisms underlying the antinociceptive effect of the extracts of plants
from the genus Phyllanthus.” Gen. Pharmacol. 1995; 26(7): 1499–1506.
Santos, A. R., et al. “Further studies on the antinociceptive action of the hydroalcohlic extracts from plants of
the genus Phyllanthus.” J. Pharm. Pharmacol. 1995; 47(1): 66–71.
Santos, A. R., et al. “Analgesic effects of callus culture extracts from selected species of Phyllanthus in mice.” J. Pharm. Pharmacol. 1994; 46(9): 755–59.
Antiviral Actions:
Cheng, H., et al. "Excoecarianin, isolated from Phyllanthus urinaria Linnea, inhibits Herpes simplex virus type 2 infection through inactivation of viral particles." Evid. Based Complement. Alternat. Med. 2009 Oct 6.
Dirjomuljono, M., et al. "Symptomatic treatment of acute tonsillo-pharyngitis patients with a combination of Nigella sativa and Phyllanthus niruri extract." Int. J. Clin. Pharmacol. Ther. 2008; 46(6): 295-306.
Yang, C., et al. "The in vitro activity of geraniin and 1,3,4,6-tetra-O-galloyl-beta-D-glucose isolated from Phyllanthus urinaria against Herpes simplex virus type 1 and type 2 infection." J. Ethnopharmacol. 2007 Apr; 110(3): 555-8.
Bagalkotkar, G., et al. "Phytochemicals from Phyllanthus niruri Linn. and their pharmacological properties: a review." J. Pharm. Pharmacol. 2006 Dec; 58(12): 1559-70.
Naik, A., et al. "Effects of alkaloidal extract of Phyllanthus niruri on HIV replication." Indian J. Med. Sci. 2003 Sep; 57(9): 387-93.
Huang, R. L., et al. “Screening of 25 compounds isolated from Phyllanthus species for anti-human hepatitis B
virus in vitro.” Phytother. Res. 2003; 17(5): 449-53.
Liu, J., et al. “Genus Phyllanthus for chronic Hepatitis B virus infection: A systematic review.” Viral Hepat. 2001; 8(5): 358–66.
Xin-Hua, W., et al. “A comparative study of Phyllanthus amarus compound and interferon in the treatment of
chronic viral Hepatitis B.” Southeast Asian J. Trop. Med. Public Health 2001; 32(1): 140–42.
Wang, M. X., et al. “Herbs of the genus Phyllanthus in the treatment of chronic Hepatitis B: Observation with
three preparations from different geographic sites.” J. Lab. Clin. Med. 1995; 126(4): 350–52.
Wang, M. X., et al. “Observations of the efficacy of Phyllanthus spp. in treating patients with chronic Hepatitis B.” 1994; 19(12): 750–52.
Thyagarajan, S. P., et al. “Effect of Phyllanthus amarus on chronic carriers of Hepatitis B virus.” Lancet 1988; 2(8614): 764–66.
Venkateswaran, P. S., et al. “Effects of an extract from Phyllanthus niruri on Hepatitis B and wood chuck
hepatitis viruses: in vitro and in vivo studies.” Proc. Nat. Acad. Sci. 1987; 84(1): 274–78.
Bhumyamalaki, et al. “Phyllanthus niruri and jaundice in children.” J. Natl. Integ. Med. Ass. 1983; 25(8): 269–72.
Thyagarajan, S. P., et al. “In vitro inactivation of HBsAG by Eclipta alba (Hassk.) and Phyllanthus niruri (Linn.).” Indian J. Med. Res. 1982; 76s: 124–30.
Notka, F., et al. “Concerted inhibitory activities of Phyllanthus amarus on HIV replication in vitro and ex vivo.” Antiviral Res. 2004 Nov; 64(2): 93-102.
Notka, F., et al. “Inhibition of wild-type human immunodeficiency virus and reverse transcriptase inhibitor-resistant variants by Phyllanthus amarus.” Antiviral Res. 2003 Apr; 58(2): 175-186.
Qian-Cutrone, J. “Niruriside, a new HIV REV/RRE binding inhibitor from Phyllanthus niruri.” J. Nat. Prod. 1996; 59(2): 196–99.
Ogata, T., et al. “HIV-1 reverse transcriptase inhibitor from Phyllanthus niruri.” AIDS Res. Hum. Retroviruses 1992; 8(11): 1937–44.
Liver Protective, Detoxification & Antioxidant Actions:
Chirdchupunseree, H., et al. "Protective activity of phyllanthin in ethanol-treated primary culture of rat hepatocytes."
J. Ethnopharmacol. 2010 Jan 11.
Krithika, R., et al. "Ameliorative potential of Phyllanthus amarus against carbon tetrachloride-induced hepatotoxicity." Acta Pol. Pharm. 2009 Sep-Oct; 66(5): 579-83.
Guhu, G., et al. "Aqueous extract of Phyllanthus amarus inhibits chromium(VI)-induced toxicity in MDA-MB-435S cells." Food Chem. Toxicol. 2009 Oct 27.
Krithika, R., et al. "Mitigation of carbon tetrachloride-induced damage by Phyllanthus amarus in liver of mice."
Acta Pol. Pharm. 2009 Jul-Aug; 66(4): 439-44.
Hau, D., et al. "Phyllanthus urinaria extract attenuates acetaminophen induced hepatotoxicity: involvement of cytochrome P450 CYP2E1." Phytomedicine. 2009 Aug; 16(8): 751-60.
Krithika, R., et al. "Isolation, characterization and antioxidative effect of phyllanthin against CCl4-induced toxicity in HepG2 cell line." Chem. Biol. Interact. 2009 Oct; 181(3): 351-8.
Yadav, N., et al. "Synergistic effect of silymarin and standardized extract of Phyllanthus amarus against CCl4-induced hepatotoxicity in Rattus norvegicus." Phytomedicine. 2008 Dec; 15(12): 1053-61.
Negi, A., et al. "Recent advances in plant hepatoprotectives: a chemical and biological profile of some important leads."
Med. Res. Rev. 2008 Sep; 28(5): 746-72.
Appiah-Opong, R., et al. "Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants." Food Chem. Toxicol. 2008; 46(12): 3598-603.
Manjrekar, A., et al. "Effect of Phyllanthus niruri Linn. treatment on liver, kidney and testes in CCl4 induced hepatotoxic rats." Indian J. Exp Biol. 2008 Jul; 46(7): 514-20.
Londhe, J., et al. "Antioxidant activity of some polyphenol constituents of the medicinal plant Phyllanthus amarus Linn." Redox. Rep. 2008; 13(5): 199-207.
Adeneye, A., et al. "Protective effect of the aqueous leaf and seed extract of Phyllanthus amarus on gentamicin and acetaminophen-induced nephrotoxic rats." J. Ethnopharmacol. 2008 Jul; 118(2): 318-23.
Faremi, T., et al. "Hepatoprotective potentials of Phyllanthus amarus against ethanol-induced oxidative stress in rats." Food Chem. Toxicol. 2008; 46(8): 2658-64.
Rai, V., et al. "Chromium-induced changes in ultramorphology and secondary metabolites of Phyllanthus amarus Schum & Thonn. - an hepatoprotective plant." Environ. Monit. Assess. 2008 Dec; 147(1-3): 307-15.
Shen, B., et al. "Phyllanthus urinaria ameliorates the severity of nutritional steatohepatitis both in vitro and in vivo." Hepatology. 2008 Feb; 47(2): 473-83.
Xu, M., et al. "Phenolic antioxidants from the whole plant of Phyllanthus urinaria." Chem. Biodivers. 2007 Sep; 4(9): 2246-52.
Jaleel, C., et al. "NaCl as a physiological modulator of proline metabolism and antioxidant potential in Phyllanthus amarus." C. R. Biol. 2007; 330(11): 806-13.
Sarkar, M., et al. "Hepatocytes are protected by herb Phyllanthus niruri protein isolate against thioacetamide toxicity." Pathophysiology. 2007 Oct; 14(2): 113-20.
Pramyothin, P., et al. "Hepatoprotective activity of Phyllanthus amarus Schum. et. Thonn. extract in ethanol treated rats: in vitro and in vivo studies." J. Ethnopharmacol. 2007 Nov; 114(2): 169-73.
Naaz, F., et al. "Hepatoprotective effect of ethanolic extract of Phyllanthus amarus Schum. et Thonn. on aflatoxin B1-induced liver damage in mice." J. Ethnopharmacol. 2007 Sep; 113(3): 503-9.
Stickel, F., et al. "Herbal medicine in the treatment of liver diseases." Dig. Liver Dis. 2007; 39(4): 293-304.
Bhattacharjee, R., et al. "Protein isolate from the herb Phyllanthus niruri modulates carbon tetrachloride-induced cytotoxicity in hepatocytes." Toxicol. Mech Methods. 2007; 17(1): 41-7.
Bhattacharjee, R., et al. Protein isolate from the herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties." Food Chem. Toxicol. 2007; 45(5): 817-26.
Chatterjee, M., et al. "Hepatoprotective effect of aqueous extract of Phyllanthus niruri on nimesulide-induced oxidative stress in vivo." Indian J. Biochem. Biophys. 2006 Oct; 43(5): 299-305.
Bhattacharjee, R., et al. "The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties." Phytother. Res. 2006; 20(7): 595-601.
Lee, C. Y., et al. "Hepatoprotective effect of Phyllanthus in Taiwan on acute liver damage induced by carbon tetrachloride." Am. J. Chin. Med. 2006; 34(3): 471-82.
Chatterjee, M., et al. "Herbal (Phyllanthus niruri) protein isolate protects liver from nimesulide induced oxidative stress." Pathophysiology. 2006 May; 13(2): 95-102.
Khatoon, S., et al. “Comparative pharmacognostic studies of three Phyllanthus species.” 2006 Mar; 104(1-2): 79-86.
Levy, C., et al. “Use of herbal supplements for chronic liver disease.” Clin. Gastroenterol Hepatol. 2004; 2(11): 947-56.
Rajeshkumar, N. V., et al. “Phyllanthus amarus extract administration increases the life span of rats with hepatocellular carcinoma.” J. Ethnopharmacol. 2000 Nov; 73(1–2): 215–19.
Padma, P., et al. "Protective effect of Phyllanthus fraternus against carbon tetrachloride-induced
mitochondrial dysfunction." Life Sci. 1999; 64(25): 2411-17.
Jeena, K. J., et al. “Effect of Emblica officinalis, Phyllanthus amarus and Picrorrhiza kurroa on n-nitrosodiethylamine induced hepatocarcinogenesis.” Cancer Lett. 1999; 136(1): 11–16.
Thabrew, M. R., et al. “Phytogenic agents in the therapy of liver disease.” Phytother. Res. 1996; 10(6): 461–67.
Prakash, A., et al. “Comparative hepatoprotective activity of three Phyllanthus species, P. urinaria, P. niruri and P.simplex, on carbon tetrachloride induced liver injury in the rat.” Phytother. Res. 1995; 9(8): 594–96.
Dhir, H., et al. “Protection afforded by aqueous extracts of Phyllanthus species against cytotoxicity induced by lead and aluminium salts.” Phytother. Res. 1990; 4(5): 172–76
Sreenivasa, R. Y. “Experimental production of liver damage and its protection with Phyllanthus niruri and
Capparis spinosa (both ingredients of LIV52) in white albino rats.” Probe 1985; 24(2): 117–19.
Syamasundar, K. V., et al. "Antihepatotoxic principles of Phyllanthus niruri herbs." J. Ethnopharmacol. 1985; 14(1): 41-4.
Anticancerous & Cellular Protective Actions:
Huang, S., et al. "Ellagic acid, the active compound of Phyllanthus urinaria, exerts in vivo anti-angiogenic effect and inhibits MMP-2 activity." Evid Based Complement Alternat Med. 2010;
Harikumar, K., et al. "Inhibition of viral carcinogenesis by Phyllanthus amarus." Integr. Cancer Ther. 2009 Sep; 8(3): 254-60.
Guhu, G., et al. "Aqueous extract of Phyllanthus amarus inhibits chromium(VI)-induced toxicity in MDA-MB-435S cells." Food Chem. Toxicol. 2009 Oct 27.
Londhe, J., et al. "Radioprotective properties of polyphenols from Phyllanthus amarus Linn." J. Radiat. Res. (Tokyo). 2009 Jul; 50(4):303-9.
Harikumar, K., et al. "Phyllanthus amarus inhibits cell growth and induces apoptosis in Dalton's lymphoma ascites cells through activation of caspase-3 and downregulation of Bcl-2." Integr. Cancer Ther. 2009 Jun; 8(2): 190-4.
Chularojmontri, L., et al. "Cytoprotective role of Phyllanthus urinaria L. and glutathione-S transferase Pi in doxorubicin-induced toxicity in H9c2 cells." J. Med. Assoc. Thai. 2009 Jun; 92 Suppl 3: S43-51.
Huang, S., et al. "Phyllanthus urinaria increases apoptosis and reduces telomerase activity in human nasopharyngeal carcinoma cells." Forsch. Komplementmed. 2009 Feb; 16(1): 34-40.
C Jagetia, G. "Radioprotective potential of plants and herbs against the effects of ionizing radiation." J. Clin. Biochem. Nutr. 2007 Mar; 40(2): 74-81.
Harikumar, K., et al. An extract of Phyllanthus amarus protects mouse chromosomes and intestine from radiation induced damages." J. Radiat. Res (Tokyo). 2007 Nov; 48(6): 469-76.
Iizuka, T, et al. "Inhibitory effects of methyl brevifolincarboxylate isolated from Phyllanthus niruri L. on platelet aggregation." Biol. Pharm. Bull. 2007; 30(2): 382-4.
Leite, D. F., et al. "The cytotoxic effect and the multidrug resistance reversing action of lignans from Phyllanthus amarus." Planta Med. 2006 Dec; 72(15): 1353-8.
Raphael, K. R., et al. "Inhibition of N-Methyl N'-nitro-N-nitrosoguanidine (MNNG) induced gastric carcinogenesis by Phyllanthus amarus extract." Asian Pac. J. Cancer Prev. 2006 Apr-Jun; 7(2): 299-302.
Hari Kumar, K. B., et al . "Inhibition of drug metabolizing enzymes (cytochrome P450) in vitro as well as in vivo by Phyllanthus amarus Schum & Thonn." Biol. Pharm. Bull. 2006; 29(7): 1310-3.
Mellinger, C. G., et al. “Chemical and biological properties of an arabinogalactan from Phyllanthus niruri.” J. Nat. Prod. 2005; 68(10): 1479-83.
Kumar, K. B., et al. “Chemoprotective activity of an extract of Phyllanthus amarus against cyclophosphamide
induced toxicity in mice.” Phytomedicine. 2005; 12(6-7): 494-500.
Raphael, K. R., et al. “Inhibition of experimental gastric lesion and inflammation by Phyllanthus amarus
extract.” J. Ethnopharmacol. 2003; 87(2-3): 193-7.
Rajeshkumar, N. V. "Antitumour and anticarcinogenic activity of Phyllanthus amarus extract." J.
Ethnopharmacol. 2002; 81(1): 17-22.
Sripanidkulchai, B., et al. “Antimutagenic and anticarcinogenic effects of Phyllanthus amarus.” Phytomedicine 2002; 9(1): 26–32.
Devi, P. U. “Radioprotective effect of Phyllanthus niruri on mouse chromosomes.” Curr. Sci. 2000; 78(10): 1245–47.
Souza, C. R., et al. “Compounds extracted from Phyllanthus and Jatropha elliptica inhibit the binding of [3H]glutamate and [3H]GMP-PNP in rat cerebral cortex membrane.” Neurochem. Res. 2000; 25(2): 211–15.
Anti-Diabetic, Anti-Cholesterol & Hypotensive Actions:
Lin, S., et al. "Antioxidant, anti-semicarbazide-sensitive amine oxidase, and anti-hypertensive activities of geraniin isolated from Phyllanthus urinaria." Food Chem. Toxicol. 2008; 46(7): 2485-92.
Modak, M., et al. "Indian herbs and herbal drugs used for the treatment of diabetes." J. Clin. Biochem. Nutr. 2007 May; 40(3): 163-73.
Amaechina, F., et al. "Hypotensive effect of aqueous extract of the leaves of Phyllanthus amarus Schum and Thonn (Euphorbiaceae)." Acta Pol. Pharm. 2007 Nov-Dec; 64(6): 547-52.
Adeneye, A. A., et al. "Hypoglycemic and hypocholesterolemic activities of the aqueous leaf and seed extract of Phyllanthus amarus in mice." Fitoterapia. 2006 Dec; 77(7-8): 511-4.
Ali, H., et al. "alpha-Amylase inhibitory activity of some Malaysian plants used to treat diabetes; with particular reference to Phyllanthus amarus." J. Ethnopharmacol. 2006 Oct; 107(3): 449-55.
Raphael, K. R., et al. “Hypoglycemic effect of methanol extract of Phyllanthus amarus Schum & Thonn on
alloxan induced diabetes mellitus in rats and its relation with antioxidant potential.” Indian J. Exp. Biol. 2002; 40(8): 905-9.
Khanna, A. K., et al. "Lipid lowering activity of Phyllanthus niruri in hyperlipemic rats." J. Ethnopharmacol. 2002; 82(1): 19-22.
Srividya, N., et al. “Diuretic, hypotensive and hypoglycaemic effect of Phyllanthus amarus.” Indian J. Exp. Biol. 1995; 33(11): 861–64.
Shimizu, M., et al. “Studies on aldose reductase inhibitors from natural products. II. Active components of a
Paraguayan crude drug, ‘paraparai mi,’ Phyllanthus niruri.” Chem. Pharm. Bull. (Tokyo) 1989; 37(9): 2531–32.
Umarani, D., et al. “Ethanol induced metabolic alterations and the effect of Phyllanthus niruri in their reversal.” Ancient Sci. Life 1985; 4(3): 174–80.
Ramakrishnan, P. N., et al. “Oral hypoglycaemic effect of Phyllanthus niruri (Linn.) leaves.” Indian J. Pharm. Sci. 1982; 44(1): 10–12.
Immunomodulatory Actions:
Mellinger, C., et al. "Chemical and immunological modifications of an arabinogalactan present in tea preparations of Phyllanthus niruri after treatment with gastric fluid." Int. J. Biol. Macromol. 2008 Aug; 43(2): 115-20.
Antiparasitic, Antimalarial, Wound-Healing, & Other Antimicrobial Actions:
Rahuman, A., et al. "Larvicidal activity of some Euphorbiaceae plant extracts against Aedes aegypti and Culex quinquefasciatus (Diptera: Culicidae)." Parasitol. Res. 2008 Apr; 102(5): 867-73.
Dapper, D., et al. "Antiplasmodial effects of the aqueous extract of Phyllantus amarus Schumach and Thonn against Plasmodium berghei in Swiss albino mice." Niger. J. Physiol. Sci. 2007 Jun-Dec; 22(1-2): 19-25.
Okigbo, R., et al. "Antimicrobial effects of Piper guineense 'Uziza' and Phyllantus amarus 'Ebe-benizo' on Candida albicans and Streptococcus faecalis." Acta Microbiol. Immunol. Hung. 2007 Dec; 54(4): 353-66.
Traoré, M., et al. "In vitro and in vivo antiplasmodial activity of 'saye', an herbal remedy used in Burkina Faso traditional medicine." Phytother. Res. 2008; 22(4): 550-1.
Shakil, N., et al. "Nematicidal prenylated flavanones from Phyllanthus niruri." Phytochemistry. 2008 Feb; 69(3): 759-64.
Mustofa, S., et al. "In vitro and in vivo antiplasmodial activity and cytotoxicity of extracts of Phyllanthus niruri L. herbs traditionally used to treat malaria in Indonesia." Southeast Asian J. Trop. Med. Public Health. 2007 Jul; 38(4): 609-15.
Mazumder, A., et al. "Antimicrobial potentiality of Phyllanthus amarus against drug resistant pathogens." Nat. Prod. Res. 2006; 20(4):323-6.
Devi, V., et al. "Effect of Phyllanthus niruri on wound healing in rats." Indian J. Physiol Pharmacol. 2005 Oct-Dec; 49(4): 487-90.
Kolodziej, H., et al. "Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells." Bioorg. Med. Chem. 2005 Dec; 13(23): 6470-6.
Subeki, S., et al. "Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri." J. Nat. Prod. 2005; 68(4): 537-9.
Kloucek, P., et al. “Antibacterial screening of some Peruvian medicinal plants used in Calleria District.” J. Ethnopharmacol. 2005 Jun; 99(2): 309-12.
Cimanga, R. K., et al. “In vitro antiplasmodial activity of callus culture extracts and fractions from fresh apical stems of Phyllanthus niruri L. (Euphorbiaceae): part 2.” J. Ethnopharmacol. 2004 Dec; 95(2-3): 399-404.
Agrawal, A., et al. “Evaluation of inhibitory effect of the plant Phyllanthus amarus against dermatophytic fungi Microsporum gypseum.” Biomed. Environ. Sci. 2004 Sep; 17(3): 359-65.
Tona, L., et al. “In vitro antiplasmodial activity of extracts and fractions from seven medicinal plants used in the Democratic Republic of Congo.” J. Ethnopharmacol. 2004 Jul; 93(1): 27-32.
Mesia, L. T. K., et al. “In-vitro antimalarial activity of Cassia occidentalis, Morinda morindoides and Phyllanthus niruri.” Ann. Trop. Med. Parasitol. 2001; 95(1): 47–57.
Tona, L., et al. “Antimalarial activity of 20 crude extracts from nine African medicinal plants used in Kinshasa, Congo.” J. Ethnopharmacol. 1999; 68(1/3): 193–203.
Farouk, A., et al. “Antimicrobial activity of certain Sudanese plants used in folkloric medicine. Screening for antibacterial activity (I).” Fitoterapia 1983; 54(1): 3–7.
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