Cipo Cabeludo Powder - Mikania hirsutissima Cipó Cabeludo Powder

Mikania hirsutissima

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search for products available from other suppliers or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

Chemical screening has revealed that cipó cabeludo contains coumarin, sesquiterpenes, flavonols, saponins, and kaurenoic acid chemicals. These kaurenoic acid chemicals have been documented with various biological activities.* For more information cipó cabeludo and it's active chemicals, please refer to the Database File for Cipó Cabeludo in the Tropical Plant Database. To see pictures of cipó cabeludo, click here. Check out the new Discussion Forums to see if anyone is talking about how they are using this natural rainforest remedy.

Traditional Uses:* for prostatitis, benign prostatic hypertrophy (BPH), and prostate pain; for urinary tract disorders (infections, cystitis, nephritis, urethritis, kidney stones); as a pain reliever for neuralgia, arthritis, and general muscle pain; as a decongestant to remove excessive mucous in the bowel, urinary tract, and lungs; for leukemia

Suggested Use: This plant is best prepared as an infusion (tea): Use one teaspoon of powder for each cup of water. Pour boiling water over herb in cup and allow to steep 10 minutes. Strain tea (or allow settled powder to remain in the bottom of cup) and drink warm. It is traditionally taken in 1/2 cup amounts, twice daily. For more complete instructions on preparing herbal infusions, see the Methods for Preparing Herbal Remedies Page.

Contraindications: While not substantiated scientifically, it is possible that cipó cabeludo may demonstrate a blood thinning effect due to its coumarin content. Consult your doctor before using this plant if you are taking coumadin drugs (or if coumadin anticoagulant-type drugs are contraindicated for your condition).

Drug Interactions: Might enhance the action of anticoagulant drugs.

Third-Party Published Research*

All available third-party research on cipó cabeludo can be found at PubMed. A partial listing of the published research on cipó cabeludo is shown below:

Anti-inflammatory Actions:
Sosa-Sequera, M., et al. "Kaurenic acid: An in vivo experimental study of its anti-inflammatory and antipyretic effects." Indian J Pharmacol. 2010 October; 42(5): 293–296.
Lim, H., et al. "Anti-inflammatory activity of the constituents of the roots of Aralia continentalis." Arch. Pharm. Res. 2009 Sep; 32(9): 1237-43.
Boller, S., et al. "Anti-inflammatory effect of crude extract and isolated compounds from Baccharis illinita DC in acute skin inflammation." J. Ethnopharmacol. 2009 Aug 25.
Suyenaga, E. S., et al. "Anti-inflammatory investigation of some species of Mikania." Phytother. Res. 2002; 16(6): 519-23.
Paiva, L. A., et al. “Anti-inflammatory effect of kaurenoic acid, a diterpene from Copaifera langsdorffi on acetic acid-induced colitis in rats.” Vascul. Pharmacol. 2002 Dec; 39(6): 303-7.

Vasorelaxant & Antispasmodic Actions:
Tirapelli, C. R., “Pharmacological comparison of the vasorelaxant action displayed by kaurenoic acid and pimaradienoic acid.” J. Pharm. Pharmacol. 2005; 57(8): 997-1004.
Ambrosio, S. R., “Role of the carboxylic group in the antispasmodic and vasorelaxant action displayed by kaurenoic acid.” J. Pharm. Pharmacol. 2004; 56(11): 1407-13.
Tirapelli, C. R., et al. “Analysis of the mechanisms underlying the vasorelaxant action of kaurenoic acid in the isolated rat aorta.” Eur. J. Pharmacol. 2004 May; 492(2-3): 233-41.

Antimicrobial Actions:
de Andrade, B., et al. "Evaluation of ent-kaurenoic acid derivatives for their anticariogenic activity." Nat Prod Commun. 2011 Jun;6(6):777-80.
Urzúa, A., et al. "A structure-activity study of antibacterial diterpenoids." Molecules. 2008 Apr; 13(4): 882-91.
Ohkoshi, E., et al. “ent-Kaurenoic acids from Mikania hirsutissima (Compositae).” Phytochemistry. 2004 Apr; 65(7): 885-90.
Wilkins, M., et al. “Characterization of the bactericidal activity of the natural diterpene kaurenoic acid.” Planta Med. 2002; 68(5): 452–54.
Davino, S. C., et al. “Antimicrobial activity of kaurenoic acid derivatives substituted on carbon-15.” Braz. J. Med. Biol. Res. 1989; 22(9): 1127–29.
de Souza, C. P., et al. “Chemoprophylaxis of schistosomiasis: molluscacidal activity of natural products—assays with adult snails and oviposition.” An. Acad. Bras. Cienc. 1984; 56(3): 333–38.

Anticanerous Actions:
Sosa-Sequera, M., et al. "Kaurenic acid: Evaluation of the in vivo and in vitro antitumor activity on murine melanoma." Indian J Pharmacol. 2011 Nov;43(6):683-8.
Cavalcanti, B., et al. "Kauren-19-oic acid induces DNA damage followed by apoptosis in human leukemia cells." J. Appl. Toxicol. 2009 Oct; 29(7): 560-8.
Ohkoshi, E., et al. “Studies on the constituents of Mikania hirsutissima (Compositae).” Chem. Pharm. Bull. 1999; 47(10): 1436–38.

Chemical Constituents:
Ohkoshi, E., et al. “ent-Kaurenoic acids from Mikania hirsutissima (Compositae).” Phytochemistry. 2004 Apr; 65(7): 885-90.
Ohkoshi, E., et al. “A novel bisnorditerpenelactone from Mikania hirsutissima.” Chem. Pharm. Bull. 2000; 48(11): 1774–75.
Ohkoshi, E., et al. “Studies on the constituents of Mikania hirsutissima (Compositae).” Chem. Pharm. Bull. 1999; 47(10): 1436–38.
Muradian, J. M., et al. “Flavonols and (-) karu-16-en-19-oic acid from Mikania hirsutissima.” Rev. Latinam. Quim. 1977; 8: 88–9.

* The statements contained herein have not been evaluated
by the Food and Drug Administration. This product is
not intended to treat, cure, mitigate or prevent any disease.
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Last updated 12-17-2012