Muira Puama Powder - Ptychopetalum, olacoides Muira Puama Powder

Ptychopetalum olacoides

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

This rainforest botanical is traditionally used in South America for its ability to increase sexual desire, libido and performance.* Much of the more recent research however has been on it's possibility to affect Alzheimer's and other actions on the brain.* For more information about muira puama (Ptychopetalum olacoides), please refer to the Database File for Muira puama in the Tropical Plant Database. To see pictures of muira puama, click here. Check out the new Discussion Forums to see if anyone is talking about how they are using this natural rainforest remedy.

Traditional Uses:* for erectile dysfunction and impotency; as a male aphrodisiac and libido promoter; as a tonic (tones, balances, strengthens) for males; for hair loss and balding; central nervous system tonic (tones, balances, strengthens) and antidepressant

Suggested Use: The active chemicals in this plant are not very water soluble. It is best prepared as an alcohol tincture. Combine 1 part bark powder with 4 parts 90 proof alcohol (everclear or vodka). Allow to macerate for 2 weeks while agitating solution daily. Strain into a clean bottle and seal. It is traditionally taken in dosages of 2-3 ml (60 to 90 drops) 2-3 times daily. For more complete instructions on preparing herbal tinctures, see the Methods for Preparing Herbal Remedies Page.

Contraindications: None reported.

Drug Interactions: None reported.





Third-Party Published Research*

All available third-party research on muira puama can be found at PubMed. A partial listing of the published research on muira puama is shown below:

Actions on Erectile Function and Libido:
Rowland, D. L., et al. “A review of plant-derived and herbal approaches to the treatment of sexual dysfunctions.” J. Sex. Marital Ther. 2003 May-Jun; 29(3): 185-205.
Waynberg, J., et al. ”Effects of Herbal vX on libido and sexual activity in premenopausal and postmenopausal women.” Adv. Ther. 2000 Sep-Oct; 17(5): 255-62.
Waynberg, J. “Male sexual asthenia—interest in a traditional plant-derived medication.” Ethnopharmacology; 1995.
Waynberg, J. “Contributions to the clinical validation of the traditional use of Ptychopetalum guyanna.” Presented at the First International Congress on Ethnopharmacology, Strasbourg, France, June 5-9, 1990.
Gaebler, H. “Revival of the drug Muira puama.” Deut. Apoth. 1979; 22(3): 94–6.

Memory Enhancement, Anti-Alzheimer's & Neuroprotective Actions:
Figueiro, M., et al. "The Amazonian herbal Marapuama attenuates cognitive impairment and neuroglial degeneration in a mouse Alzheimer model." Phytomedicine. 2011 Feb 15;18(4):327-33.
Figueiro, M., et al. "Acetylcholinesterase inhibition in cognition-relevant brain areas of mice treated with a nootropic Amazonian herbal (Marapuama)." Phytomedicine. 2010 Oct;17(12):956-62.
Tang, W., et al. "Novel NGF-potentiating diterpenoids from a Brazilian medicinal plant, Ptychopetalum olacoides." Bioorg Med Chem Lett. 2009 Feb 1;19(3):882-6.
da Silva, A., et al. "MK801- and scopolamine-induced amnesias are reversed by an Amazonian herbal locally used as a "brain tonic"." Psychopharmacology (Berl). 2009 Jan;202(1-3):165-72.
Tang, W., et al. "Clerodane diterpenoids with NGF-potentiating activity from Ptychopetalum olacoides." J Nat Prod. 2008 Oct;71(10):1760-3.
da Silva, A., et al. "Serotonin receptors contribute to the promnesic effects of P. olacoides (Marapuama)." Physiol Behav. 2008 Sep 3;95(1-2):88-92.
Siqueira, I., et al. "Antioxidant activities of Ptychopetalum olacoides ("muirapuama") in mice brain." Phytomedicine. 2007 Nov;14(11):763-9.
da Silva, A. L., et al. "Promnesic effects of Ptychopetalum olacoides in aversive and non-aversive learning paradigms." J. Ethnopharmacol. 2007 Feb; 109(3): 449-457.
da Silva, A. L., et al. “Memory retrieval improvement by Ptychopetalum olacoides in young and aging mice.” J. Ethnopharmacol. 2004 Dec; 95(2-3): 199-203.
Siqueira, I. R., et al. “Neuroprotective effects of Ptychopetalum olacoides Bentham (Olacaceae) on oxygen and glucose deprivation induced damage in rat hippocampal slices.” Life Sci. 2004 Aug; 75(15): 1897-906.
Siqueira, I. R., et al. “Ptychopetalum olacoides, a traditional Amazonian "nerve tonic," possesses anticholinesterase activity.” Pharmacol. Biochem. Behav. 2003 Jun; 75(3): 645-50.
Siqueira, I. R., et al. “Psychopharamcological properties of Ptychopetalum olachoides Bentham (Olacaceae).” Pharmaceutical Biol. 1998; 36(5): 327–34.
Forgacs, P., et al. “Phytochemical and biological activity studies on 18 plants from French Guyana.” Plant Med. Phytother. 1983; 17(1): 22–32.
Dias Da Silva, Rodolpho. “Medicinal plants of Brazil. Botanical and pharmacognostic studies. Muira puama.” Rev. Bras. Med. Pharm. 1925; 1(1): 37–41.

Anti-Anxiety, Anti-Depressant & Nervine Actions:
Piato, A., et al. "Anti-stress effects of the "tonic" Ptychopetalum olacoides (Marapuama) in mice." Phytomedicine. 2010 Mar;17(3-4):248-53.
Piato, A., et al. "Antidepressant profile of Ptychopetalum olacoides Bentham (Marapuama) in mice." Phytother Res. 2009 Apr;23(4):519-24.
Piato, A., et al. "Effects of Marapuama in the chronic mild stress model: further indication of antidepressant properties." J Ethnopharmacol. 2008 Jul 23;118(2):300-4.
da Silva, A. L., et al. “Anxiogenic properties of Ptychopetalum olacoides Benth. (Marapuama).” Phytother. Res. 2002; 16(3): 223-6.
Siqueira, I. R., et al. “Psychopharamcological properties of Ptychopetalum olachoides Bentham (Olacaceae).” Pharmaceutical Biol. 1998; 36(5): 327–34.

Hypotensive Actions:
Raymond-Hamet, A. “Physiological action of the extract of muira puama.” Comp. Rend. Soc. Biol. 1932; 109: 1064-7
Olofsson, Eric. “Action of extract of Liriosma ovata on the blood pressure, vessels and respiration of the rabbit.” Compt. Rend. Soc. Biol. 1927; 97: 1639-40.

Anti-fatigue, Tonic, & Adaptogenic Actions:
Mendes, F. R., et al. "Brazilian plants as possible adaptogens: An ethnopharmacological survey of books edited in Brazil." J. Ethnopharmacol. 2007 Feb; 109(3): 493-500.
Bucci, L. R., et al. ”Selected herbals and human exercise performance.” Am. J. Clin. Nutr. 2000 Aug; 72(2 Suppl): 624S-36S.
Paiva, L., et al. “Effects of Ptychocepalum olacoides extract on mouse behaviour in forced swimming and open field tests.” Phytother. Res. 1998; 12(4): 294–96.
Waynberg, J. “Male sexual asthenia—interest in a traditional plant-derived medication.” Ethnopharmacology; 1995.
Hanawa, M., et al. “Composition containing an extract from muira puama root and plant worm extract.” Taisho Pharmacuetical Co., Ltd., Tokyo, United States Patent No. 6024984, 2000.
Siqueira, I. R., et al. “Psychopharamcological properties of Ptychopetalum olachoides Bentham (Olacaceae).” Pharmaceutical Biol. 1998; 36(5): 327–34.

Anti-cholesterol Actions:
Jayasuriya, H., et al. “Diterpenoid, steroid, and triterpenoid agonists of liver X receptors from diversified terrestrial plants and marine sources.” J. Nat. Prod. 2005; 68(8): 1247-52.
Cherksey, B. D. “Method of preparing Muira puama extract and its use for decreasing body fat percentage and increasing lean muscle mass.” United States Patent No. 5516516, 1996.

Antimicrobial Actions:
Correia, A., et al. "Amazonian plant crude extract screening for activity against multidrug-resistant bacteria." Eur Rev Med Pharmacol Sci. 2008 Nov-Dec;12(6):369-80.

Chemicals Identified:
Tang, W., et al. "Eight new clerodane diterpenoids from the bark of Ptychopetalum olacoides." Nat Prod Commun. 2011 Mar;6(3):327-32.
Tang, W., et al. "Novel NGF-potentiating diterpenoids from a Brazilian medicinal plant, Ptychopetalum olacoides." Bioorg Med Chem Lett. 2009 Feb 1;19(3):882-6.
Tang, W., et al. "Clerodane diterpenoids with NGF-potentiating activity from Ptychopetalum olacoides." J Nat Prod. 2008 Oct;71(10):1760-3.



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by the Food and Drug Administration. This product is
not intended to treat, cure, mitigate or prevent any disease.
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Last updated 1-9-2013