Sangre de Grado Resin (Croton lechleri) from Raintree Nutrition - Sangre de Grado Resin (Croton lechleri) - Sangre de Grado Resin (Croton lechleri) - Sangre de Grado Resin (Croton lechleri) Sangre de Grado Resin

Croton lechleri

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

A pure natural resin extracted from the sangre de grado tree (Croton lechleri) which is also called "dragon's blood." Sangre de grado resin is a storehouse of plant chemicals including proanthocya nidins (antioxidants), simple phenols, diterpenes, phytosterols, and biologically active alkaloids and lignans. Scientists have attributed many of the biologically active properties of the resin to two main "active" constituents: an alkaloid named taspine, and a lignan named dimethylcedrusine.* This natural resin has long been used as a wound healer, as well as for cancer and diarrhea.*For more complete information on this powerful plant of the rainforest, please see the Plant Database File on Sangre de Grado. More information can also be found in the new Antimicrobial Guide. To see pictures of sangre de grado, click here.

Traditional Uses:* to stop bleeding and to seal, and heal wounds, burns, cuts, tooth extractions; for herpes virus ulcers (taken internally and applied topically); for skin fungi, rashes, and dermatitis; for insect bites, poison ivy and other itchy or allergic skin reactions; for stomach ulcers, ulcerative colitis, dysentery and diarrhea

Suggested Use: Take 15 drops in water 1-2 times daily. Use topically by applying liberally to affected area of skin. Avoid contact with eyes.

Contraindications: Not to be used during pregnancy or breast-feeding.

Drug Interactions: None known.


Other Observations: Will stain clothing and other textiles.





Third-Party Published Research*

All available third-party research on sangre de grado can be found at PubMed. A partial listing of the published research on sangre de grado is shown below:

Anticancerous & Cytotoxic Actions:
Montopoli, M., et al. "Croton lechleri sap and isolated alkaloid taspine exhibit inhibition against human melanoma SK23 and colon cancer HT29 cell lines." J Ethnopharmacol. 2012 Dec 18;144(3):747-53.
Zhang, Y., et al. "Antitumor activity of taspine by modulating the EGFR signaling pathway of Erk1/2 and Akt in vitro and in vivo." Planta Med. 2011 Nov;77(16):1774-81.
Alonso-Castro, A., et al. "Antitumor effect of Croton lechleri Mull. Arg. (Euphorbiaceae). J Ethnopharmacol. 2012 Mar 27;140(2):438-42.
Lu, W., et al. "A novel taspine analog, HMQ1611, inhibits growth of non-small cell lung cancer by inhibiting angiogenesis." Oncol Lett. 2012 Nov;4(5):1109-1113.
Zhang, Y., et al. "A novel angiogenesis inhibitor impairs lovo cell survival via targeting against human VEGFR and its signaling pathway of phosphorylation." Cell Death Dis. 2012 Oct 11;3:e406.
He, H., et al. "Tas13D inhibits growth of SMMC-7721 cell via suppression VEGF and EGF expression." Asian Pac J Cancer Prev. 2012;13(5):2009-14.
Zhan, Y., et al. "A novel taspine derivative, HMQ1611, suppresses adhesion, migration and invasion of ZR-75-30 human breast cancer cells." Breast Cancer. 2012 Aug 9.
Zhang, Y., et al. "Facile synthesis and biological evaluation of novel symmetrical biphenyls as antitumor agents." Med Chem. 2012 Mar;8(2):145-50.
Zhang, Y., et al. "Effects of taspine on proliferation and apoptosis by regulating caspase-3 expression and the ratio of Bax/Bcl-2 in A431 cells." Phytother Res. 2011 Mar;25(3):357-64.
Takami, Y., et al. "Proanthocyanidin derived from the leaves of Vaccinium virgatum suppresses platelet-derived growth factor-induced proliferation of the human hepatic stellate cell line LI90." Hepatol Res. 2010 Apr;40(4):337-45.
Fayed, W., et al. "Identification of a novel topoisomerase inhibitor effective in cells overexpressing drug efflux transporters." PLoS One. 2009 Oct 2;4(10):e7238.
Zhang, Y., et al. "[Inhibitory effect of taspine on mouse S180 sarcoma and its mechanism]." Zhongguo Zhong Yao Za Zhi. 2007 May;32(10):953-6.
Gonzales, G. F., et al. "Medicinal plants from Peru: a review of plants as potential agents against cancer." Anticancer Agents Med, Chem. 2006 Sep; 6(5) :429-44.
Rossi, D., et al. “Evaluation of the mutagenic, antimutagenic and antiproliferative potential of Croton lechleri (Muell. Arg.) latex.” Phytomedicine. 2003 Mar; 10(2-3): 139-44.
Sandoval, M., et al. “Sangre de grado (Croton palanostigma) induces apoptosis in human gastrointestinal cancer cells.” J. Ethnopharmacol. 2002; 80(2-3): 121–9.
Chen, Z. P., et al. “Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon’s blood.” Planta Med. 1994; 60(6): 541–45.
Pieters, L., et al. “Isolation of a dihydrobenzofuran lignan from South American dragon’s blood (Croton sp.) as an inhibitor of cell proliferation.” J. Nat. Prod. 1993; 56(6): 899–906.
Itokawa, H., et al. “A cytotoxic substance from sangre de grado.” Chem. Pharm. Bull. 1991; 39(4): 1041–42.

Wound Healing, Neuromuscular, & Antioxidant Actions:
De Marino, S., et al. "Identification of minor secondary metabolites from the latex of Croton lechleri (Muell-Arg) and evaluation of their antioxidant activity." Molecules. 2008 Jun 1;13(6):1219-29.
Frum, Y., et al. "In vitro 5-lipoxygenase and anti-oxidant activities of South African medicinal plants commonly used topically for skin diseases." Skin Pharmacol. Physiol. 2006; 19(6): 329-35.
Rollinger, J. M., "Taspine: bioactivity-guided isolation and molecular ligand-target insight of a potent acetylcholinesterase inhibitor from Magnolia x soulangiana." J. Nat. Prod. 2006 Sep; 69(9): 1341-6.
Dong, Y., et al. “Enhancement of wound healing by taspine and its effect on fibroblast.” Zhong. Yao. Cai. 2005; 28(7): 579-82.
Dong, Y. L., et al. “Effect of taspine hydrochloride on skin wound healing in rats and its mechanism.” Zhong. Xi. Yi. Jie. He. Xue. Bao. 2005 Sep; 3(5): 386-90.
Lopes, M. I., et al. “Mutagenic and antioxidant activities of Croton lechleri sap in biological systems.” J. Ethnopharmacol. 2004 Dec; 95(2-3): 437-45.
Jones, K. “Review of sangre de drago (Croton lechleri)--a South American tree sap in the treatment of diarrhea, inflammation, insect bites, viral infections, and wounds: traditional uses to clinical research.” J. Altern. Complement. Med. 2003 Dec; 9(6): 877-96.
Desmarchelier, C., et al. “Effects of sangre de drago from Croton lechleri Muell.-Arg. on the production of active oxygen radicals.” J. Ethnopharmacol. 1997; 58: 103–8.
Phillipson, J. D. “A matter of some sensitivity.” Phytochemistry. 1995 Apr; 38(6): 1319-43.
Chen, Z. P., et al. “Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon’s blood.” Planta Med. 1994; 60(6): 541–45.
Porras-Reyes, B. H., et al. “Enhancement of wound healing by the alkaloid taspine defining mechanism of action.” Proc. Soc. Exp. Biol. Med. 1993; 203(1): 18–25.
Vaisberg, A. J., et al. “Taspine is the cicatrizant principle in sangre de grado extracted from Croton lechleri.” Planta Med. 1989; 55(2): 140–43.
Macrae, W. D., et al. “Studies on the pharmacological activity of Amazonian Euphorbiaceae.” J. Ethnopharmacol. 1988; 22(2): 143–72.

Pain-relieving & Anti-inflammatory Actions:
Pereira, U., et al. "Effects of sangre de drago in an in vitro model of cutaneous neurogenic inflammation." Exp Dermatol. 2010 Sep;19(9):796-9.
Xiangming, L., et al. “Effects of dragon's blood resin and its component loureirin B on tetrodotoxin-sensitive voltage-gated sodium currents in rat dorsal root ganglion neurons.” Sci. China C. Life Sci. 2004 Aug; 47(4): 340-8.
Tsacheva, I., et al. “Complement inhibiting properties of dragon's blood from Croton draco. ”Z. Naturforsch. 2004; 59(7-8): 528-32.
Jones, K. “Review of sangre de drago (Croton lechleri)--a South American tree sap in the treatment of diarrhea, inflammation, insect bites, viral infections, and wounds: traditional uses to clinical research.” J. Altern. Complement. Med. 2003 Dec; 9(6): 877-96.
Risco, E., et al. “Immunomodulatory activity and chemical characterisation of sangre de drago (dragon's blood) from Croton lechleri.” Planta Med. 2003; 69(9): 785-94.
Miller, M. J., et al. “Inhibition of neurogenic inflammation by the Amazonian herbal medicine sangre de grado.” J. Invest. Dermatol. 2001; 117(3): 725–30.
Perdue, G. P., et al. “South American plants II: Taspine isolation and anti-inflammatory activity.” J. Pharm. Sci. 1979; 68(1): 124–26.

Antimicrobial Actions:
Extracts of sangre de grado have demonstrated antiviral activity against influenza, parainfluenza, Herpes simplex viruses I and II, and Hepatitis A and B. The antiviral and anti-diarrheal properties of sangre de grado have come to the attention of the pharmaceutical industry over the last 10 years. A U.S.-based pharmaceutical company has filed patents on three pharmaceutical preparations that contain antiviral constituents and novel chemicals (a group of plant flavonoids they've named SP-303), extracted from the bark and resin of sangre de grado. Their patented drugs include an oral product for the treatment of respiratory viral infections, a topical antiviral product for the treatment of herpes, and an oral product for the treatment of persistent diarrhea.
Rodriguez-Garcia, A., et al. "Development and in vitro evaluation of biopolymers as a delivery system against periodontopathogen microorganisms." Acta Odontol Latinoam. 2010;23(2):158-63.
Gurgel, L. A., et al. “In vitro antifungal activity of dragon's blood from Croton urucurana against dermatophytes.” J. Ethnopharmacol. 2005; 97(2): 409-12.
Williams, J. E. “Review of antiviral and immunomodulating properties of plants of the Peruvian rainforest with a particular emphasis on Una de Gato and Sangre de Grado.” Altern. Med. Rev. 2001; 6(6): 567–79.
Sidwell R., et al. “Influenza virus-inhibitory effects of intraperitoneally and aerosol-administered SP-303, a plant flavonoid.” Chemotherapy. 1994; 40(1): 42–50.
Chen, Z. P., et al. “Studies on the anti-tumour, anti-bacterial, and wound-healing properties of dragon’s blood.” Planta Med. 1994; 60(6): 541–45.
Rao, G. S., et al. “Antimicrobial agents from higher plants. Dragon's blood resin.”J. Nat. Prod. 1982 Sep-Oct; 45(5): 646-8.

Anti-ulcer & Anti-diarrhea Actions:
Cottreau, J., et al. "Crofelemer for the treatment of secretory diarrhea." Expert Rev Gastroenterol Hepatol. 2012 Feb;6(1):17-23.
Tradtrantip, L., et al. "Crofelemer, an antisecretory antidiarrheal proanthocyanidin oligomer extracted from Croton lechleri, targets two distinct intestinal chloride channels." Mol Pharmacol. 2010 Jan;77(1):69-78
Tran, C. D., et al. "The role of Amazonian herbal medicine Sangre de Grado in Helicobacter pylori infection and its association with metallothionein expression." Helicobacter. 2006 Apr; 11(2): 134-5.
Paula, A. C., et al. "The gastroprotective effect of the essential oil of Croton cajucara is different in normal rats than in malnourished rats." Br. J. Nutr. 2006 Aug; 96(2): 310-5.
Fischer, H., et al. “A novel extract SB-300 from the stem bark latex of Croton lechleri inhibits CFTR-mediated chloride secretion in human colonic epithelial cells.” J. Ethnopharmacol. 2004; 93(2-3): 351-7.
Jones, K. “Review of sangre de drago (Croton lechleri)--a South American tree sap in the treatment of diarrhea, inflammation, insect bites, viral infections, and wounds: traditional uses to clinical research.” J. Altern. Complement. Med. 2003 Dec; 9(6): 877-96.
Miller, M. J., et al. “Treatment of gastric ulcers and diarrhea with the Amazonian herbal medicine sangre de grado.” Am. J. Physiol. Gastrointest. Liver Physiol. 2000; 42: G192–200.
Gabriel, S. E., et al. “A novel plant-derived inhibitor of cAMP-mediated fluid and chloride secretion.” Am. J. Physiol. 1999 Jan; 276(1 Pt 1): G58-63.

Vasoconstrictive Action:
Froldi, G., et al. "Activity of sap from Croton lechleri on rat vascular and gastric smooth muscles." Phytomedicine. 2009 Aug;16(8):768-75.



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Last updated 1-2-2013