Spiro Capsules: A dynamic herbal combination of chanca piedra whole herb (Phyllanthus niruri), Bellaco caspi bark (Himatanthus sucuuba), tamamuri bark (Brosimum acutifolium), matico leaf (Piper aduncum), huacapu bark (Minquartia guianensis), and ajos sacha bark & leaf (Mansoa alliacea) SPIRO Capsules

120 capsules (650 mg each)

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

A synergistic formula of 6 rainforest botanicals which are traditionally used in South America for syphilis (a type of spirochete bacteria) and other bacterial conditions.* Lymes Disease is also caused by a similar spirochete bacteria.* This product was featured in an article by the Health Sciences Institute (see page 4).

For more information on the individual ingredients in the Spiro formula, follow the links provided below to the plant database files in the Tropical Plant Database.

Ingredients: A herbal blend of chanca piedra, bellaco caspi, tamamuri, matico, huacapu, and ajos sacha. To prepare this natural remedy yourself: use two parts chanca piedra and one part each of the remaining plants in the list. To make a small amount... "1 part" could be one tablespoon (you'd have 7 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce or one cup or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.

Suggested Use: Take 2 grams twice daily. (one gram is approximately 1/2 teaspoon by volume)

Contraindications: None reported.

Drug Interactions: None reported.

Other Practitioner Observations:
  • All of the plants in this formula have demonstrated antimicrobial effects in laboratory studies. Supplementing the diet with probiotics and digestive enzymes is advisable when this formula is used for longer than 30 days.*

Third-Party Published Research*

This rainforest formula has not been the subject of any clinical research. A partial listing of the published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research.

Chanca Piedra (Phyllanthus niruri)
Subeki, S., et al. "Anti-babesial and anti-plasmodial compounds from Phyllanthus niruri." J. Nat. Prod. 2005; 68(4):537-9.
Amin, Z., et al. "Assessment of in vitro antioxidant, antibacterial and immune activation potentials of aqueous and ethanol extracts of Phyllanthus niruri." J Sci Food Agric. 2012 Jul;92(9):1874-7
Ranilla, L, et al. "Antimicrobial activity of an Amazon medicinal plant (Chancapiedra) (Phyllanthus niruri L.) against Helicobacter pylori and lactic acid bacteria." Phytother Res. 2012 Jun;26(6):791-9.
Narayanan, A., et al. "Antibacterial activity of selected medicinal plants against multiple antibiotic resistant uropathogens: a study from Kolli Hills, Tamil Nadu, India." Benef Microbes. 2011 Sep;2(3):235-43.
Chowdhury, S., et al. "The lignan niranthin poisons Leishmania donovani topoisomerase IB and favours a Th1 immune response in mice." EMBO Mol Med. 2012 Oct;4(10):1126-43.
Okigbo, R., et al. "Antimicrobial effects of Piper guineense 'Uziza' and Phyllantus amarus 'Ebe-benizo' on Candida albicans and Streptococcus faecalis." Acta Microbiol. Immunol. Hung. 2007 Dec; 54(4): 353-66.
Mazumder, A., et al. "Antimicrobial potentiality of Phyllanthus amarus against drug resistant pathogens." Nat. Prod. Res. 2006; 20(4): 323-6.
Okigbo, R. N., et al. "Antimicrobial effects of Piper guineense 'Uziza' and Phyllantus amarus 'Ebe-benizo' on Candida albicans and Streptococcus faecalis." Acta Microbiol. Immunol. Hung. 2007 Dec; 54(4): 353-66.
Farouk, A., et al. "Antimicrobial activity of certain Sudanese plants used in folkloric medicine. Screening for antibacterial activity (I)." Fitoterapia 1983; 54(1): 3-7.
Kloucek, P., et al. "Antibacterial screening of some Peruvian medicinal plants used in Calleria District." J. Ethnopharmacol. 2005 Jun; 99(2): 309-12.

Bellaco Caspi (Himatanthus sucuuba, lancifolius)
Kuigoua, G., et al. "Minor Secondary Metabolic Products from the Stem Bark of Plumeria rubra Linn. Displaying Antimicrobial Activities. Planta Med. 2009 Nov 20.
Souza, W., et al. "Antimicrobial activity of alkaloidal fraction from barks of Himatanthus lancifolius." Fitoterapia. 2004 Dec; 75(7-8): 750-3.
Tundis, R., et al. "Biological and pharmacological activities of iridoids: recent developments." Mini. Rev. Med. Chem. 2008; 8(4): 399-420.
Lucetti, D., et al. "Anti-inflammatory effects and possible mechanism of action of lupeol acetate isolated from Himatanthus drasticus (Mart.) Plumel" J Inflamm (Lond) 2010; 7: 60.
Saleem, M. "Lupeol, A Novel Anti-inflammatory and Anti-cancer Dietary Triterpene" Cancer Lett. 2009 November 28; 285(2): 109115.
Little, J., et al. "Plumericin; an antimicrobial agent from Plumeria multiflora." Arch. Biochem. 1951; 30(2): 445-52.
Persinos-Perdue, G., et al. " South American plants. III. Isolation of fulvoplumierin from Himatanthus sucuuba (Apocynaceae). J. Pharm. Sci. 1978; 67: 1322.
Wood, C. A., et al. "A bioactive spirolactone iridoid and triterpenoids from Himatanthus sucuuba." Chem. Pharm. Bull. 2001; 49(11): 1477-1478.
De Silva, J. R., et al. "Triterpenic esters from Himatanthus sucuuba (Spruce) Woodson." Quimica Nova 1998; 21(6): 702-704.
Castillo, D., et al. Spirolactone iridoids might be responsible for the antileishmanial activity of a Peruvian traditional remedy made with Himatanthus sucuuba (Apocynaceae)." J. Ethnopharmacol. 2007 Jun; 112(2): 410-4.

Tamamuri (Brosimum acutifolium)
Correia, A., et al. "Amazonian plant crude extract screening for activity against multidrug-resistant bacteria." Eur Rev Med Pharmacol Sci. 2008 Nov-Dec;12(6):369-80.
Tundis, R., et al. "Biological and pharmacological activities of iridoids: recent developments." Mini. Rev. Med. Chem. 2008 Apr;8(4):399-420.
Herforth, A., et al. "Amazonian Women's Medicine: Treatments for Mycoses." Poster: Society for Economic Botany 2002 vol 56(4).
Herforth, A., et al. " Antifungal plants of the Peruvian Amazon: A survey of ethnomedical uses and biological activity." Cornel University Publication 2002
Takashima, J., et al. "Brosimacutins J-M, four new flavonoids from Brosimum acutifolium and their cytotoxic activity." Planta Med. 2005; 71(7): 654-8.
Takashima J, et al. "Mururins A-C, three new lignoids from Brosimum acutifolium and their protein kinase inhibitory activity. Planta Med. 2002; 68(7): 621-5.

Matico (Piper aduncum)
Orjala, J., et al. “New monoterpene-substituted dihydrochalcones from Piper aduncum.Helv. Chim. Acta 1993; 76(4): 1481-1488.
Kloucek, P., et al. “Antibacterial screening of some Peruvian medicinal plants used in Calleria district.” J. Ethnopharmacol. 2005 Jun; 99(2): 309-12.
Lemos, T. L. G., et al. “Antimicrobial activity of essential oils of Brazilian plants.” Phytother. Res. 1990; 4(2): 82-84.
Lentz, D. L., et al. “Antimicrobial properties of Honduran medicinal plants.” J. Ethnopharmacol, 1998; 63(3): 253-263.
Trillini, B., et al. “Chemical composition and antimicrobial activity of essential oil of Piper angustifolium.” Planta Med. 1996; 62(4): 372-373.
Orjala, J., et al. “Cytotoxic and antibacterial dihydrochalcones from Piper aduncum.” J. Nat. Prod. 1994; 57(1): 18-26.
Orjala, J., et al. “Three new prenylated benzoic acid derivatives and molluscicidal sesquiterpenoids from Piper aduncum leaves.” Planta Med. Suppl. 1992; 58(1) A714-.
Orjala, J., et al. “Five new prenylated p-hydroxybenzoic acid derivatives with antimicrobial and molluscicidal activity from Piper aduncum leaves.” Planta Med. 1993; 59(6): 546-551.
Orjala, J., et al. “Aduncamide, a cytotoxic and antibacterial beta-phenylethylamine-derived amide from Piper aduncum.Nat. Prod. Lett.
Cde Almeida, R. R., et al. "Chemical variation in Piper aduncum and biological properties of its dillapiole-rich essential oil." Chem. Biodivers. 2009; 6(9):1427-34.
Orjala, J., et al. “Two chromenes and a prenylated benzoic acid derivative from Piper aduncum.” Phytochemistry. 1993; 34(3): 813-818.
Lago, J. H., et al. “Benzoic acid derivatives from Piper species and their fungitoxic activity against Cladosporium cladosporioides and C. sphaerospermum.J. Nat. Prod. 2004; 67(11):1783-8.
Navickiene, H., et al. “Composition and antifungal activity of essential oils from Piper aduncum, Piper arboreum and Piper tuberculatum.” Quim. Nova. 2006; 20( 3): 467-470.
Braga, F. G., et al. "Antileishmanial and antifungal activity of plants used in traditional medicine in Brazil." J. Ethnopharmacol. 2007 May; 111(2): 396-402.
Lohezic, L. E., et al. “Antiviral and cytotoxic activities of some Indonesian plants.” Fitoterapia. 2002 Aug; 73(5): 400-5.
Parise-Filho, R., et al. "Dillapiole as Antileishmanial Agent: Discovery, Cytotoxic Activity and Preliminary SAR Studies of Dillapiole Analogues." Arch Pharm (Weinheim). 2012 Dec;345(12):934-44.
Valadeau, C., et al. "Medicinal plants from the Yanesha (Peru): evaluation of the leishmanicidal and antimalarial activity of selected extracts." J. Ethnopharmacol. 2009 Jun; 123(3): 413-22.
Flores, N., et al. "Antiparasitic activity of prenylated benzoic acid derivatives from Piper species." Phytochemistry. 2009; 70(5):621-7.
Torres-Santos, E. C., et al. Selective effect of 2',6'-dihydroxy-4'-methoxychalcone isolated from Piper aduncum on Leishmania amazonensis.” Antimicrob. Agents Chemother. 1999; 43(5): 1234-1241.
Torres-Santos, E. C., et al. Improvement of in vitro and in vivo antileishmanial activities of 2', 6'-dihydroxy-4'-methoxychalcone by entrapment in poly(D,L-lactide) nanoparticles.” Antimicrob. Agents Chemother. 1999; 43(7): 1776-8.
Rapado, L., et al. "Molluscicidal and ovicidal activities of plant extracts of the Piperaceae on Biomphalaria glabrata (Say, 1818)." J Helminthol. 2011 Mar;85(1):66-72.
Batista, J. M. Jr, et al. "Natural chromenes and chromene derivatives as potential anti-trypanosomal agents." Biol. Pharm. Bull. 2008; 31(3): 538-40.

Huacapu (Minquartia guianensis)
Ruiz, L., et al. "Plants used by native Amazonian groups from the Nanay River (Peru) for the treatment of malaria." J Ethnopharmacol. 2011 Jan 27;133(2):917-21.
Gachet, M., et al. "Assessment of anti-protozoal activity of plants traditionally used in Ecuador in the treatment of leishmaniasis." J Ethnopharmacol. 2010 Mar 2;128(1):184-97.
Rasmussem, H. B., et al. "Absolute configuration and antiprotozoal activity of minquartynoic acid." J. Nat. Prod. 2000; 63(9): 1295-1296.
Gung, B., et al. "Total synthesis of (-)-minquartynoic acid: an anti-cancer, anti-HIV natural product." Org Lett. 2002 Jul 25;4(15):2517-9.
Rashid, M. A., et al. "Absolute stereochemistry and anti-HIV activity of minquartynoic acid, a polyacetylene from Ochanostachys amentacea." Nat Prod. Lett. 2001; 15(1): 21-26 .
El-Seedi, H. R., et al. "Triterpenes, lichexanthone and an acetylenic acid from Minquartia guianensis." Phytochemistry. 1994; 35 (5): 1297-1299.
Jovel, E. M., et al. "An ethnobotanical study of the traditional medicine of the Mestizo people of Suni Mirano,
Marles, R. J., et al. "Isolation of a novel cytotoxic polyacetylene from a traditional anthelmintic medicinal plant, Minquartia guianensis." J. Nat. Prod. 1989; 52(2): 261-266.Loreto, Peru." J. Ethnopharmacol. 1996; 53: 149-156.

Ajos Sacha (Mansoa alliacea, Adenocaymma alliaceum)
Canapaty, S., et al. "Composition of leaf oil from Adenocalymma alliaceum and its antimicrobial activity." Indian Perfumer 2004; 48(3): 323-329.
Rao, A. M., et al. "Antimicrobial activity of the leaf capsules of Adenocalymma alliaceum." Indian Drugs. 1985: 22(7): 364-365.
Silva, T. M., et al. "Molluscicidal activities of six species of Bignoniaceae from north-eastern Brazil, as measured against Biomphalaria glabrata under laboratory conditions." Ann. Trop. Med. Parasitol. 2007 Jun; 101(4):359-65.
Rana, B. K., et al. "Antifungal activity of an aqueous Capsules of leaves of garlic creeper (Adenocaymma alliaceum Miers.)." Pharmaceutical Biol. 1999; 37(1):. 13-16.
Singh, U. P., et al. "A rapid method for detecting fungi-toxic substances." World Journal of Microbiology and Biotechnology. 1996; 12(3): 301-302.
Khurana, S., et al. "Effect of plant capsules on the activity of three papaya viruses." J. Gen. Appl. Microbiol. 1970; 16: 225-230.
Ushamalini, C., et al. "Management of charcoal rot of cowpea using biocontrol agents and plant products." Indian Phytopathol. 1997; 50(4): 504-507.
Ushamalini, C., et al. "Suppression of charcoal rot and wilt pathogens of cowpea by botanicals." Plant Disease Research 1997; 12(2): 113-117.
Itokawa, H., et al. "Cytotoxic naphthoquinones from Mansoa alliacea." Phytochemistry. 1992; 31(3): 1061-1062.
Sharma, R. K.. "Phytosterols: Wide-spectrum antibacterial agents." Bioorg. Chem. 1993; 21(1): 49-60.

*The statements contained herein have not been evaluated
by the Food and Drug Administration. The information contained herein is intended and provided for education, research, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plants and/or formulas described herein are not intended to treat, cure, diagnose, mitigate or prevent any disease and no medical claims are made.
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Last updated 12-28-2012