Bowel Support: plants traditionally used for bowel, intestines, colon, IBS, crohn's, colitis

120 capsules (650 mg each)

This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.

A synergistic formula of 7 rainforest botanicals traditionally used in South America Crohn's, colitis, IBS and other bowel problems.* For more information on the individual ingredients in Amazon Blood Support, follow the links provided below to the plant database files in the Tropical Plant Database. More information can also be found in the Organ-Specific Guide.

Ingredients: A herbal blend of cat's claw, macela, boldo, simarouba, jurubeba, tayuya, and anamu. To prepare this natural remedy yourself: Use two parts cat's claw and one part each for the remaining plants shown in the list above. To make a small amount... "1 part" could be one tablespoon (you'd have 8 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce or one cup or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.

Suggested Use: Take 2-3 capsules three times daily on an empty stomach.

  • Not to be used during pregnancy or while breast-feeding.
  • This product should not be used with medications intended to suppress the immune system.
Drug Interactions: May potentiate blood thinning medications such as Warfarin. May reduce the effect of immune suppressants.

Other Practitioner Observations:
  • Several plants in this formula contain a low concentration of coumarin which has an anticoagulant effect. People with blood disorders such as hemophilia, or those on blood thinning medications should be monitored closely.
  • Cat's claw and jurubeba have been documented to have an antifertility effect. Those seeking to become pregnant or those undergoing treatment for infertility should not use this formula.

Third-Party Published Research*

This rainforest formula has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.

Cat's Claw (Uncaria tomentosa)
Cat's claw has been traditionally used as a bowel cleanser and anti-inflammatory for Crohn's, colitis, diverticulitis, irritable bowel syndrome (IBS), and other bowel problems; as well as for stomach ulcers and ulcerative colitis and as an ulcer preventative, stomach and bowel protector. It has demonstrated anti-inflammatory actions in the studies cited below.
Akhtar, N., et al. "Current nutraceuticals in the management of osteoarthritis: a review." Ther Adv Musculoskelet Dis. 2012 Jun;4(3):181-207.
Rojas-Duran, R., et al. "Anti-inflammatory activity of Mitraphylline isolated from Uncaria tomentosa bark." J Ethnopharmacol. 2012 Oct 11;143(3):801-4.
Allen-Hall, L., et al. "Uncaria tomentosa acts as a potent TNF-alpha inhibitor through NF-kappaB." J. Ethnopharmacol. 2010 Feb 17;127(3):685-93.
Zeng, K., et al. "Synthesis and biological evaluation of quinic acid derivatives as anti-inflammatory agents." Bioorg. Med. Chem. Lett. 2009 Sep 15; 19(18): 5458-60.
Erowele, G., et al. "Pharmacology and therapeutic uses of cat's claw." Am. J. Health Syst. Pharm. 2009 Jun 1; 66(11): 992-5.
Amaral, S., et al. "Plant extracts with anti-inflammatory properties--a new approach for characterization of their bioactive compounds and establishment of structure-antioxidant activity relationships." Bioorg. Med. Chem. 2009 Mar; 17(5): 1876-83.
Yuan, D., et al. "Anti-inflammatory effects of rhynchophylline and isorhynchophylline in mouse N9 microglial cells and the molecular mechanism." Int. Immunopharmacol. 2009 Dec; 9(13-14):1549-54.
Pero, R. "Method of preparation and composition of a water soluble extract of the bioactive component of the plant species Uncaria for enhancing immune, anti-inflammatory, anti-tumor and DNA repair processes of warm blooded animals." United States Patent No. 7,595,064. September 29, 2009
Hardin, S. R. "Cat's claw: An Amazonian vine decreases inflammation in osteoarthritis." Complement. Ther. Clin. Pract. 2007 Feb; 13(1): 25-8.
Allen-Hall, L., et al. "Treatment of THP-1 cells with Uncaria tomentosa extracts differentially regulates the expression if IL-1beta and TNF-alpha." J. Ethnopharmacol. 2007 Jan; 109(2): 312-7.
Badilla, B., et al. "Edema induced by Bothrops asper (Squamata: Viperidae) snake venom and its inhibition by Costa Rican plant extracts." Rev. Biol. Trop. 2006 Jun; 54(2):245-52.
Miller, M. J., et al. "The chrondoprotective actions of a natural product are associated with the activation of IGF-1 production by human chondrocytes despite the presence of IL-1beta." BMC Complement. Altern. Med. 2006 Apr; 6: 13.
Miller, M. J., et al. "Early relief of osteoarthritis symptoms with a natural mineral supplement and a herbomineral combination: a randomized controlled trial [ISRCTN38432711]." J. Inflamm. 2005 Oct; 2:11.
Valerio, L. G., et al. "Toxicological aspects of the South American herbs cat's claw (Uncaria tomentosa) and Maca (Lepidium meyenii): a critical synopsis." Toxicol. Rev. 2005; 24(1): 11-35.
Setty, A. R., et al. "Herbal medications commonly used in the practice of rheumatology: mechanisms of action, efficacy, and side effects." Semin. Arthritis Rheum. 2005; 34(6): 773-84.
Sheng, Y., et al. “An active ingredient of Cat's Claw water extracts: identification and efficacy of quinic acid.” J. Ethnopharmacol. 2005 Jan 15; 96(3):
Aguilar, J. L., et al. “Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae).” J. Ethnopharmacol. 2002; 81(2): 271–76.
Sandoval, M., et al., “Anti-inflammatory and antioxidant activities of cat’s claw (Uncaria tomentosa and Uncaria guianensis) are independent of their alkaloid content." Phytomedicine. 2002; 9(4): 325–37.
Mur, E., et al. “Randomized double blind trial of an extract from the pentacyclic alkaloid-chemotype of Uncaria tomentosa for the treatment of rheumatoid arthritis.” J. Rheumatol. 2002 Apr; 29(4): 678–81.
Sandoval-Chacon, M., et al. “Anti-inflammatory actions of cat’s claw: the role of NF-kappaB.” Aliment. Pharmacol. Ther. 1998; 12(12): 1279–89.
Recio, M. C., et al. “Structural requirements for the anti-inflammatory activity of natural triterpenoids.” Planta Med. 1995; 61(2): 182–85.
Aquino, R., et al. “Plant metabolites. New compounds and anti-inflammatory activity of Uncaria tomentosa." J. Nat. Prod. 1991; 54: 453–59.
Cerri, R., et al. “New quinovic acid glycosides from Uncaria tomentosa." J. Nat. Prod. 1988; 51: 257–61.

Boldo (Peumus boldus)
Boldo's main active chemical, boldine, has shown in animal studies to provide anti-inflammatory and antispasmodic action, as well as the ability to protect against colon damage and inflammation in induced colitis and colon inflammation. A recent human study demonstrated that boldo relaxes smooth muscle tissue and prolongs intestinal transit.
Gotteland, M., et al. “Protective effect of boldine in experimental colitis.” Planta Med. 1997; 63(4): 311–15.
Gotteland, M., et al. “Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers.” Rev. Med. Chil. 1995; 123(8): 955–60.
Lévy-Appert-Collin, M. C., et al. “Galenic preparations from Peumus boldus leaves (Monimiacea).” J. Pharm. Belg. 1977; 32: 13.
Hughes, D. W., et al. “Alkaloids of Peumus boldus. Isolation of laurotetanine and laurolitsine.” J. Pharm. Sci. 1968.
Lau, Y., et al. "Boldine protects endothelial function in hyperglycemia-induced oxidative stress through an antioxidant mechanism." Biochem Pharmacol. 2012 Nov 22. doi:pii: S0006-2952(12)00751-4.
Sobarzo-Sánchez, E., et al. "Applied biological and physicochemical activity of isoquinoline alkaloids: oxoisoaporphine and boldine." Molecules. 2012 Sep 12;17(9):10958-70.
Falé P., et al. "Acetylcholinesterase inhibition, antioxidant activity and toxicity of Peumus boldus water extracts on HeLa and Caco-2 cell lines." Food Chem Toxicol. 2012 Aug;50(8):2656-62.
Lau, Y., et al. "The aporphine alkaloid boldine improves endothelial function in spontaneously hypertensive rats." Exp Biol Med (Maywood). 2012 Jan 1;237(1):93-8.
Fernández, J. et al. "Effect of boldo (Peumus boldus Molina) infusion on lipoperoxidation induced by cisplatin in mice liver." Phytother Res. 2009; 23(7):1024-7.
Yu, B., et al."The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells." J. Med. Food. 2009 Oct; 12(5): 1074-83.
Konrath, E., et al. "Antioxidant and pro-oxidant properties of boldine on hippocampal slices exposed to oxygen-glucose deprivation in vitro." Neurotoxicology. 2008 Nov; 29(6): 1136-40.
Hidalgo, M., et al. "Photostability and photoprotection factor of boldine and glaucine." J. Photochem. Photobiol. B. 2005 Jul; 80(1): 65-9.
O'brien, P., et al. “Boldine and its antioxidant or health-promoting properties.” Chem. Biol. Interact. 2006 Jan; 159(1): 1-17.
Milian, L., et al. “Reactive oxygen species (ROS) generation inhibited by aporphine and phenanthrene alkaloids semi-synthesized from natural boldine.” Chem. Pharm. Bull. 2004; 52(6): 696-9.
Santanam, N., et al. “A novel alkaloid antioxidant, Boldine and synthetic antioxidant, reduced form of RU486, inhibit the oxidation of LDL in-vitro and atherosclerosis in vivo in LDLR(-/-) mice.” Atherosclerosis. 2004 Apr; 173(2):203-10.

Macela (Achyrocline satureoides, Egletes viscosa)
Macela has been reported in several animal studies with mice and rats, to possess analgesic, anti-inflammatory, and smooth-muscle (gastrointestinal) relaxant properties internally without toxicity, in addition to anti-inflammatory and analgesic actions externally. This may explain why macela has long been used effectively for many types of pain, gastrointestinal difficulties, menstrual cramps, and asthma.
Santini, J., et al. "Antiulcer effects of Achyrocline satureoides (Lam.) DC (Asteraceae) (Marcela), a folk medicine plant, in different experimental models." J Ethnopharmacol. 2010 Jul 20;130(2):334-9.
Guedes, M. et al. "Gastroprotective mechanisms of centipedic acid, a natural diterpene from Egletes viscosa LESS." Biol Pharm Bull. 2008 Jul;31(7):1351-5.
Rao, V. S., et al. “Investigations on the gastroprotective and antidiarrhoeal properties of ternatin, a tetramethoxyflavone from Egletes viscosa.” Planta Med. 1997 Apr; 63(2): 146-9.
Calou, I., et al. "Topically applied diterpenoids from Egletes viscosa (Asteraceae) attenuate the dermal inflammation in mouse ear induced by tetradecanoylphorbol 13-acetate- and oxazolone." Biol Pharm Bull. 2008 Aug;31(8):1511-6.
De Souza, K., et al. "Influence of excipients and technological process on anti-inflammatory activity of quercetin and Achyrocline satureioides (Lam.) D.C. extracts by oral route." Phytomedicine. 2007 Feb;14(2-3):102-8.
Melo, C. M., et al. "12-Acetoxyhawtriwaic acid lactone, a diterpene from Egletes viscosa, attenuates capsaicin-induced ear edema and hindpaw nociception in mice: possible mechanisms." Planta Med. 2006 Jun; 72(7): 584-9.
Hnatyszyn, O., et al. “Flavonoids from Achyrocline satureioides with relaxant effects on the smooth muscle of guinea pig corpus cavernosum.” Phytomedicine. 2004; 11(4): 366-9.
Rao. V. S., et al. “Ternatin, an anti-inflammatory flavonoid, inhibits thioglycolate-elicited rat peritoneal neutrophil accumulation and LPS-activated nitric oxide production in murine macrophages.” Planta Med. 2003; 69(9): 851-3.  
Guedes, M. M., et al. “Antinociceptive and gastroprotective effects of diterpenes from the flower buds of Egletes viscosa.” Planta Med. 2002; 68(11): 1044-6.
Lima, M. A., et al. ”Biologically active flavonoids and terpenoids from Egletes viscosa.Phytochemistry. 1996; 41(1): 217-23.
Souza, M. F., et al. “Anti-anaphylactic and anti-inflammatory effects of ternatin, a flavonoid isolated from Egletes viscosa Less.” Braz. J. Med. Biol. Res. 1992; 25(10): 1029-32.
Simoes, C. M., “Anti-inflammatory action of Achyrocline satureoides extracts applied topically.” Fitoterapia. 1988; 59(5): 419–21.
Simoes, C. M., et al. “Pharmacological investigations on Achyrocline satureoides (Lam). D.C., Compositae.” J. Ethnopharmacol. 1988 Apr; 22(3): 281–93.

Simarouba (Simarouba amara)
The Merck Institute reported that simarouba was 91.8% effective against intestinal amebas in humans in a 1944 study and, in 1962, other researchers found that simarouba showed active anti-amebic activities in humans. In the 1990s scientists again documented simarouba's ability to kill the most common dysentery-causing organism, Entamoeba histolytica, as well as two diarrhea-causing bacteria, Salmonella and Shigella.
Muganza, D., et al. "In vitro antiprotozoal and cytotoxic activity of 33 ethonopharmacologically selected medicinal plants from Democratic Republic of Congo." J Ethnopharmacol. 2012 May 7;141(1):301-8.
Garcia, M., et al. "Activity of Cuban Plants Extracts against Leishmania amazonensis." ISRN Pharmacol. 2012;2012:104540.
Francois, G., et al. ”Antimalarial and cytotoxic potential of four quassinoids from Hannoa chlorantha and Hannoa klaineana, and their structure-activity relationships.” Int. J. Parasitol. 1998; 28(4): 635-40.
Franssen, F. F., et al. “In vivo and in vitro antiplasmodial activities of some plants traditionally used in Guatemala against malaria.” Antimicrob. Agents Chemother. 1997; 41(7): 1500–3.
Wright, C. W., et al. “Quassinoids exhibit greater selectivity against Plasmodium falciparum than against Entamoeba histoyltica, Giardia intestinalis or Toxoplasma gondii in vitro." J. Eukaryot. Microbiol. 1993; 40(3): 244–46.
Kirby, G. C., et al. “In vitro studies on the mode of action of quassinoids with activity against chloroquine-resistant Plasmodium falciparum.Biochem. Pharmacol. 1989; 38(24): 4367–74.
O’Neill, M. J., et al. “Plants as sources of antimalarial drugs, Part 6. Activities of Simarouba amara fruits." J. Ethnopharmacol. 1988; 22(2): 183–90.
O’Neill, M. J., et al. “The activity of Simarouba amara against chloroquine-resistant Plasmodium falciparum in vitro." J. Pharm. Pharmacol. 1987; Suppl. 39: 80.
Monjour, I., et al. “Therapeutic trials of experimental murine malaria with the quassinoid, glaucarubinone.” C. R. Acad. Sci. Ill. 1987; 304(6): 129–32.
Trager, W., et al. “Antimalarial activity of quassinoids against chloroquine-resistant Plasmodium falciparum in vitro." Am. J. Trp. Med. Hyg. 1981; 30(3): 531–37.
Duriez, R., et al. “Glaucarubin in the treatment of amebiasis." Presse Med. 1962; 70: 1291.
Spencer, C. F., et al. “Survey of plants for antimalarial activity.” Lloydia 1947; 10: 145–74.
Cuckler, A. C., et al. “Efficacy and toxicity of simaroubidin in experimental amoebiasis.” Fed. Proc. 1944; 8: 284.
Shepheard, S., et al. "Persistent carriers of Entameba histolytica." Lancet 1918: 501.

Jurubeba (Solanum paniculatum)
Jurubeba has been reported with antiulcer activity. In animal studies it was reported to inhibit gastric acid secretion induced by stress and various chemical agents, as well as prevented gastric lesions from developing. Additionally it was reported to inhibit gastric acid secretion in mice with the ulcer-causing bacteria H. pylori. Researchers summarized: "Collectively, the results validate folk use of Solanum paniculatum plant to treat gastric disorders."
Botion, L. M., et al. “Effects of the Brazilian phytopharmaceutical product Ierobina® on lipid metabolism and intestinal tonus.” J. Ethnopharmacol. 2005 Nov; 102(2): 137-42.
Braga, F. T., et al. Jurubeba. Centro Universitário de Lavras, Lavras-MG Brazil, 2002.
Mesia-Vela, S., et al. “Solanum paniculatum L. (Jurubeba): Potent inhibitor of gastric acid secretion in mice.” Phytomedicine 2002; 9(6): 508–14.
Vieira, P/. et al. "Solanum paniculatum L. leaf and fruit extracts: assessment of modulation of cytotoxicity and genotoxicity by micronucleus test in mice." J Med Food. 2010 Dec;13(6):1424-30
Endringer, D., et al. "Evaluation of Brazilian plants on cancer chemoprevention targets in vitro." Phytother Res. 2010 Jun;24(6):928-33.

Tayuya (Cayaponia tayuya)
Tayuya is traditionally used by natural health practitioners in the United States for irritable bowel syndrome, dyspepsia and sluggish digestion, neuralgia, sciatica, gout, headaches, and rheumatism. It has demonstrated anti-inflammatory and rain-relieving actions in the following studies.
Escandell, J. M., et al. "Inhibition of delayed-type hypersensitivity by Cucurbitacin R through the curbing of lymphocyte proliferation and cytokine expression by means of nuclear factor AT translocation to the nucleus." J Pharmacol Exp Ther. 2010 Feb;332(2):352-63.
Aquila, S., et al. "Anti-inflammatory activity of flavonoids from Cayaponia tayuya roots." J Ethnopharmacol. 2009 Jan 21;121(2):333-7.
Escandell, J., et al. "Dihydrocucurbitacin B inhibits delayed type hypersensitivity reactions by suppressing lymphocyte proliferation." J Pharmacol Exp Ther. 2007 Sep;322(3):1261-8.
Siqueira, J., et al. "Anti-inflammatory effects of a triterpenoid isolated from Wilbrandia ebracteata Cogn." Life Sci. 2007 Mar 20;80(15):1382-7.
Escandell, J. M., et al. "Cucurbitacin R reduces the inflammation and bone damage associated with adjuvant arthritis in Lewis rats by suppression of TNF-{alpha} in T lymphocytes and macrophages." J. Pharmacol. Exp. Ther. 2006 Feb; 532(1-2): 145-54.
Escandell, J. M., et al. “Dihydrocucurbitacin B, isolated from Cayaponia tayuya, reduces damage in adjuvant-induced arthritis.” Eur. J. Pharmacol. 2006 Feb; 532(1-2): 145-54.
Recio, M. C., et al. “Anti-inflammatory activity of two cucurbitacins isolated from Cayaponia tayuya roots.” Planta Med. 2004; 70(5): 414-20.
Himeno, E., et al. “Structures of cayaponosides A, B, C and D, glucosides of new nor-cucurbitacins in the roots of Cayaponia tayuya.” Chem. Pharm. Bull. (Tokyo) 1992; 40(10): 2885–87.
Ruppelt, B. M., et al. “Pharmacological screening of plants recommended by folk medicine as anti-snake venom—I. Analgesic and anti-inflammatory activities.” Mem. Inst. Oswaldo Cruz 1991; 86 (Suppl. 2): 203–5.
Rios, J. L., et al. “A study of the anti-inflammatory activity of Cayaponia tayuya root.” Fitoterapia 1990; 61(3): 275–78.
Faria, M. R. and E. P. Schenkel. “Caracterizacao de cucurbitacinas em especies vegetais cohecidas popularmente como taiuiá.” Ciencia e Cultura (São Paulo) 1987; 39: 970–73.
Bauer, R., et al. “Cucurbitacins and flavone C-glycosides from Cayaponia tayuya.” Phytochemisty. 1984: 1587–91.

Anamu (Petiveria alliacea)
Anamu has been documented in various studies over the years with antimicrobial, analgesic, anti-inflammatory, antiprotozoal, and immune stimulant actions.
de Morais Lima, G., et al. "Database Survey of Anti-Inflammatory Plants in South America: A Review" Int J Mol Sci. 2011; 12(4): 2692–2749.
Gomes, P. B., et al. “Study of antinociceptive effect of isolated fractions from Petiveria alliacea L. (tipi) in mice.” Biol. Pharm. Bull. 2005; 28(1): 42-6.
Lopes-Martins, R. A., et al. “The anti-inflammatory and analgesic effects of a crude extract of Petiveria alliacea L. (Phytolaccaceae).” Phytomedicine. 2002; 9(3): 245-48.
Dunstan, C. A., et al. “Evaluation of some Samoan and Peruvian medicinal plants by prostaglandin biosynthesis and rat ear oedema assays.” J. Ethnopharmacol. 1997 Jun; 57(1): 35-56.
Germano, D., et al. “Pharmacological assay of Petiveria alliaceae. Oral anti-inflammatory activity and gastrotoxicity of a hydro alcoholic root extract.” Fitoterapia. 1993; 64(5): 459-467
Germano, D. H., et al. “Topical anti-inflammatory activity and toxicity of Petiveria alliaceae.” Fitoterapia. 1993; 64(5): 459-67.
de Lima, T. C., et al. “Evaluation of antinociceptive effect of Petiveria alliacea (Guine) in animals.” Mem. Inst. Oswaldo Cruz. 1991; 86 Suppl 2: 153-58.
Di Stasi, L. C., et al. “Screening in mice of some medicinal plants used for analgesic purposes in the state of Saõ Paulo.” J. Ethnopharmacol. 1988; 24(2/3): 205–11.
Kim, S., et al. “Antibacterial and antifungal activity of sulfur-containing compounds from Petiveria alliacea L.” J. Ethnopharmacol. 2006 Mar; 104(1-2): 188-92.
Kubec, R., et al. “The lachrymatory principle of Petiveria alliacea.” Phytochemistry. 2003 May; 63(1): 37-40.
Ruffa, M. J., et al. “Antiviral activity of Petiveria alliacea against the bovine diarrhea virus. Chemotherapy 2002; 48(3): 144-47.
Benevides, P. J., et al. “Antifungal polysulphides from Petiveria alliacea L.” Phytochemistry. 2001; 57(5): 743-7.
Caceres, A., et al. “Plants used in Guatemala for the treatment of protozoal infections. I. Screening of activity to bacteria, fungi and American trypanosomes of 13 native plants.” J. Ethnopharmacol. 1998 Oct; 62(3): 195-202.
Berger, I., et al. “Plants used in Guatemala for the treatment of protozoal infections: II. Activity of extracts and fractions of five Guatemalan plants against Trypanosoma cruzi.” J. Ethnopharmacol. 1998 Sep; 62(2): 107-15.

*The statements contained herein have not been evaluated
by the Food and Drug Administration. The information contained herein is intended and provided for education, research, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plants and/or formulas described herein are not intended to treat, cure, diagnose, mitigate or prevent any disease and no medical claims are made.
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Last updated 1-4-2013