120 capsules (650 mg each)
This product is no longer sold by Raintree Nutrition, Inc. See the main product page for more information why. Try doing a google search or see the rainforest products page to find other companies selling rainforest herbal supplements or rainforest plants if you want to make this rainforest formula yourself.
A synergistic formula of rainforest plants traditionally used in South America ulcers, acid reflux and sluggish digestion.* For more information on the individual ingredients in Amazon Digestion Support, follow the links provided below to the plant database files in the Tropical Plant Database.
Ingredients: A proprietary blend of picăo preto, boldo, carqueja, jurubeba, espinheira santa, guacatonga, and gervâo. To prepare this natural remedy yourself: use two parts espinheira santa, 2 parts carqueja, two parts guacatonga and 1 part each of the remaining herbs in the list. To make a small amount... "1 part" could be one tablespoon (you'd have 10 tablespoons of the blended herbal formula). For larger amounts, use "1 part" as one ounce or one cup or one pound. Combine all the herbs together well. The herbal mixture can then be stuffed into capsules or brewed into tea, stirred into juice or other liquid, or taken however you'd like.
Suggested Use: Take 1-2 grams by weight (1 tsp by volume) with each meal or as directed by a health professional.
Drug Interactions: May potentiate anticoagulant and antihypertensive medications.
- Not to be used during pregnancy, while breast-feeding or while seeking to become pregnant.
- Several plants in this formula have anticoagulant activity or contain naturally-occurring coumarin. The formula is contraindicated for persons with bleeding disorders such as hemophilia.
- Several plants in this formula may reduce blood pressure. Those with low blood pressure should be monitored for this possible effect.
Other Practitioner Observations: Several ingredients in this formula have demonstrated antacid actions in animal studies and this formula should not be used by persons with low stomach acid.
Third-Party Published Research*
This rainforest formula has not been the subject of any clinical research. A partial listing of third-party published research on each herbal ingredient in the formula is shown below. Please refer to the plant database files by clicking on the plant names below to see all available documentation and research on each plant ingredient.
Picão Preto (Bidens pilosa)
Picăo preto has shown in rat studies to protect against chemical- and bacteria-induced gastric lesions and ulcers and, also, to reduce gastric acid secretion. The activity noted in these studies was higher than that shown by two prescription anti-ulcer drugs used as controls.
Horiuchi, M., et al. "Effects of Bidens pilosa L. var. radiata Scherff on experimental gastric lesion."
J Nat Med. 2010 Oct;64(4):430-5.
Lans, C. "Comparison of plants used for skin and stomach problems in Trinidad and Tobago with Asian ethnomedicine." J. Ethnobiol. Ethnomedicine. 2007 Jan; 3(1): 3.
Atta, A. H., et al. "Evaluation of some medicinal plant extracts for antidiarrhoeal activity." Phytother. Res. 2005 Jun; 19(6): 481-5.
Tan, P. V., et al. “Effects of methanol, cyclohexane and methylene chloride extracts of Bidens pilosa on various gastric ulcer models in rats.” J. Ethnopharmacol. 2000; 73(3): 415–21.
Alvarez, A., et al. “Gastric antisecretory and antiulcer activities of an ethanolic extract of Bidens pilosa L. var. radiata Schult. Bip.” J. Ethnopharmacol. 1999; 67(3): 333–40.
Avalos, A. A., et al. “Influence of extracts from leaves and stem of Bidens pilosa on experimental ulcerogenesis in rats.” Rev. Cubana Farm. 1984; 18(2): 143–50.
Boldo (Peumus boldus)
Boldo has demonstrated in various studies over the years to protect the liver, to stimulate the production of bile in the liver, as well as to stimulate digestion, increase the secretion of gastric juices and stimulate the production of bile and its secretion from the gallbladder.
Sobarzo-Sánchez, E., et al. "Applied biological and physicochemical activity of isoquinoline alkaloids: oxoisoaporphine and boldine." Molecules. 2012 Sep 12;17(9):10958-70.
O'brien, P., et al. "Boldine and its antioxidant or health-promoting properties." Chem. Biol. Interact. 2006 Jan; 159(1): 1-17.
Reiniger, I. W., et al. “Boldine action against the stannous chloride effect.” J. Ethnopharmacol. 1999 Dec; 68(1-3): 345-8.
Gotteland, M., et al. “Protective effect of boldine in experimental colitis.” Planta Med. 1997; 63(4): 311–15.
Gotteland, M., et al. “Effect of a dry boldo extract on oro-cecal intestinal transit in healthy volunteers.” Rev. Med. Chil. 1995; 123(8): 955–60.
Kang, J. J., et al. “Studies on neuromuscular blockade by boldine in the mouse phrenic nerve diaphragm.” Planta Med. 1999; 65(2): 178–79.
Kang, J. J., et al. “Effects of boldine on mouse diaphragm and sarcoplasmic reticulum vesicles isolated from skeletal muscle.” Planta Med. 1998; 64(1): 18–21.
Backhouse, N., et al. “Anti-inflammatory and antipyretic effects of boldine.” Agents Actions 1994; 42(3–4): 114–17.
Carqueja (Baccharis genistelloides, trimera)
Carqueja's antacid, antiulcer, and hypotensive properties were documented in two Brazilian animal studies in 1992. Its antiulcer and analgesic properties were reported in a 1991 clinical study that showed that carqueja reduced gastric secretions and had an analgesic effect in rats with Helicobacter pylori ulcers. That study concluded that carqueja "may relieve gastrointestinal disorders by reducing acid secretion and gastrointestinal hyperactivity." A later study, in 2000, confirmed its antiulcerogenic effect when a water extract of carqueja administered to rats protected them from alcohol-induced ulcers. In 2011, researchers began searching for the active chemicals in carqueja which provided these anti-ulcerous actions.
Biondo, T., et al. "Antisecretory actions of Baccharis trimera (Less.) DC aqueous extract and isolated compounds: analysis of underlying mechanisms." J Ethnopharmacol. 2011 Jun 22;136(2):368-73.
Gonzales, E., et al. “Gastric cytoprotection of Bolivian medicinal plants.” J. Ethnopharmacol. 2000; 70(3):329–33.
Gamberini, M. T., et al. “Açoes antiúlcera e antiácida do extracto aquoso e das fraçoes da Baccharis trimera.”
Anais XII Simposio de Plantas Medicinais do Brasil. UFP: Curitiba, Paraná, 15–17 September 1992.
Sousa, B., et al., “Avaliaçao da atividade antiulcera do extrato bruto e fraçoes de Baccharis trimera.” Anais XII
Simposio de Plantas Medicinais do Brasil. UFP: Curitiba, Paraná, 15–17 September 1992.
Gamberini, M. T., et al. “Inhibition of gastric secretion by a water extract from Baccharis triptera. Mart.” Mem. Inst. Oswaldo Cruz. 1991; 86(Suppl. 2): 137-9.
Jurubeba (Solanum paniculatum)
Jurubeba has been reported with antiulcer activity. In animal studies it was reported to inhibit gastric acid secretion induced by stress and various chemical agents, as well as prevented gastric lesions from developing. Additionally it was reported to inhibit gastric acid secretion in mice with the ulcer-causing bacteria H. pylori. Researchers summarized, "Collectively, the results validate folk use of Solanum paniculatum plant to treat gastric disorders."
Botion, L. M., et al. “Effects of the Brazilian phytopharmaceutical product Jerobina® on lipid metabolism and intestinal tonus.” J. Ethnopharmacol. 2005 Nov; 102(2): 137-42.
Braga, F. T., et al. Jurubeba. Centro Universitário de Lavras, Lavras-MG Brazil, 2002.
Mesia-Vela, S., et al. “Solanum paniculatum L. (Jurubeba): Potent inhibitor of gastric acid secretion in mice.” Phytomedicine 2002; 9(6): 508–14.
Vieira, P. et al. "Solanum paniculatum L. leaf and fruit extracts: assessment of modulation of cytotoxicity and genotoxicity by micronucleus test in mice." J Med Food. 2010 Dec;13(6):1424-30
Vieira, P. et al. "Assessment of mutagenicity and cytotoxicity of Solanum paniculatum L. extracts using in vivo micronucleus test in mice." Braz J Biol. 2010 Aug;70(3):601-6.
Endringer, D., et al. "Evaluation of Brazilian plants on cancer chemoprevention targets in vitro." Phytother Res. 2010 Jun;24(6):928-33.
Espinheira Santa (Maytenus ilicifolia, aquifolium)
Espinheira santa's antiulcerous abilities were demonstrated in a 1991 study which showed that a simple hot water extract was as effective as two of the leading antiulcer drugs, ranitidine (Zantac®) and cime-tidine (Tagamet®). This research was confirmed again in 2009 and 2012. In 1997 a Japanese research group filed a patent on the biologically active antiulcer compounds found in espinheira santa as a new antiulcer drug.
Baggio, C., et al. "In vivo/in vitro studies of the effects of the type II arabinogalactan isolated from Maytenus ilicifolia Mart. ex Reissek on the gastrointestinal tract of rats." Z Naturforsch C. 2012 Jul-Aug;67(7-8):405-10.
Baggio, C., et al. "Muscarinic-dependent inhibition of gastric emptying and intestinal motility by fractions of Maytenus ilicifolia Mart ex. Reissek." J Ethnopharmacol. 2009 Jun 25;123(3):385-91.
Baggio, C., et al. "Flavonoid-rich fraction of Maytenus ilicifolia Mart. ex. Reiss protects the gastric mucosa of rodents through inhibition of both H+,K+ -ATPase activity and formation of nitric oxide." J Ethnopharmacol. 2007 Sep 25;113(3):433-40.
de Andrade, S.., et al. "Evaluation of the antiulcerogenic activity of Maytenus robusta (Celastraceae) in different experimental ulcer models." J Ethnopharmacol. 2007 Sep 5;113(2):252-7.
Cipriani, T. R., et al. "A polysaccharide from a tea (infusion) of Maytenus ilicifolia leaves with anti-ulcer protective effects." J. Nat. Prod. 2006; 69(7):1018-21.
Ferreira, P. M., et al. “A lyophilized aqueous extract of Maytenus ilicifolia leaves inhibits histamine-mediated acid secretion in isolated frog gastric mucosa.” Planta Med. 2004 Jun; 219(2): 319-24.
Jorge, R. M., et al. “Evaluation of antinociceptive, anti-inflammatory and antiulcerogenic activities of Maytenus ilicifolia.” J. Ethnopharmacol. 2004 Sep; 94(1): 93-100.
Tabach, R., et al. “Evaluation of the anti-ulcerogenic activity of a dry extract of Maytenus ilicifolia Martius ex. Reiss produced by a jet spouted bed dryer.” Pharmazie. 2003 Aug; 58(8): 573-6.
Leite, J. P., et al. “Isolation and HPLC quantitative analysis of flavonoid glycosides from Brazilian beverages (Maytenus ilicifolia and M. aquifolium).” J. Agric. Food Chem. 2001; 49(8): 3796-801.
Queiroga, C. L., et al. “Evaluation of the antiulcerogenic activity of friedelan-3beta-ol and friedelin isolated from Maytenus ilicifolia (Celastraceae).”J. Ethnopharmacol. 2000 Oct; 72(3): 465-8.
Souza-Formigoni, M. L., et al. “Antiulcerogenic effects of two Maytenus species in laboratory animals.” J. Ethnopharmacol. August 1991.
Guacatonga (Casearia sylvestris)
Guacatonga's antacid and antiulcerogenic actions have been reported in several animal studies. One study reported it prevented lab-induced acute gastric mucosal injury equivalent to the antiulcer drug cimetidine (Tagamet®).
Ferreira, P., et al. "Folk uses and pharmacological properties of Casearia sylvestris: a medicinal review." An Acad Bras Cienc. 2011 Dec;83(4):1373-84.
Esteves, I., et al. “Gastric antiulcer and anti-inflammatory activities of the essential oil from Casearia sylvestris Sw.” J. Ethnopharmacol. 2005 Oct; 101(1-3): 191-6.
Sertie, J. A., et al. “Antiulcer activity of the crude extract from the leaves of Casearia slyvestris.” Pharmaceutical Biol. 2000; 38(2): 112–19.
Basile, A. C., et al. “Pharmacological assay of Casearia sylvestris. I: Preventive anti-ulcer activity and toxicity of the leaf crude extract.” J. Ethnopharmacol. 1990; 30(2): 185–97.
Gervâo (Stachytarpheta jamaicensis, cayennensis)
Gervâo has demonstrated in animal studies to possess antacid, antiulcer, and laxative effects. One study reported that it increased intestinal motility, protected against ulcers from various chemical agents, and inhibited gastric secretion. A chemical in gervâo, verbascoside, was reported in 2010 to inhibit proton pump activity, much like the PPI antacid drugs sold.
Singh, N., et al. "Verbascoside isolated from Tectona grandis mediates gastric protection in rats via inhibiting proton pump activity." Fitoterapia. 2010 Oct;81(7):755-61.
Hausmann, M., et al. "In vivo treatment with the herbal phenylethanoid acteoside ameliorates intestinal inflammation in dextran sulphate sodium-induced colitis." Clin Exp Immunol. 2007 May;148(2):373-81.
Lee, J. H., et al. "The effect of acteoside on histamine release and arachidonic acid release in RBL-2H3 mast cells." Arch. Pharm. Res. 2006 Jun; 29(6): 508-13.
Penido, C., et al. “Anti-inflammatory and anti-ulcerogenic properties of Stachytarpheta cayennensis (L.C. Rich) Vahl.” J. Ethnopharmacol. 2006 Mar; 104(1-2): 225-33.
Mesia-Vela, S., et al. “Pharmacological study of Stachytarpheta cayennensis Vahl in rodents.” Phytomedicine. 2004; 11(7-8): 616-24.
Vela, S. M., et al. “Inhibition of gastric acid secretion by the aqueous extract and purified extracts of
Stachytarpheta cayennensis.” Planta Med. 1997; 63(1): 36–9.
Almeida, C. E., et al. “Analysis of antidiarrhoeic effect of plants used in popular medicine.” Rev. Saude. Publica. 1995; 29(6): 428–33.
*The statements contained herein have not been evaluated
by the Food and Drug Administration. The information contained herein is intended and provided for education, research, entertainment and information purposes only. This information is not intended to be used to diagnose, prescribe or replace proper medical care. The plants and/or formulas described herein are not intended to treat, cure, diagnose, mitigate or prevent any disease and no medical claims are made.
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Last updated 1-12-2013